Glial regulation of critical period plasticity
Animal behavior, from simple to complex, is dependent on the faithful wiring of neurons into functional neural circuits. Neural circuits undergo dramatic experience-dependent remodeling during brief developmental windows called critical periods. Environmental experience during critical periods of pl...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-11-01
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| Series: | Frontiers in Cellular Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fncel.2023.1247335/full |
| _version_ | 1797626591224791040 |
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| author | Jacob Starkey Eric J. Horstick Eric J. Horstick Sarah D. Ackerman |
| author_facet | Jacob Starkey Eric J. Horstick Eric J. Horstick Sarah D. Ackerman |
| author_sort | Jacob Starkey |
| collection | DOAJ |
| description | Animal behavior, from simple to complex, is dependent on the faithful wiring of neurons into functional neural circuits. Neural circuits undergo dramatic experience-dependent remodeling during brief developmental windows called critical periods. Environmental experience during critical periods of plasticity produces sustained changes to circuit function and behavior. Precocious critical period closure is linked to autism spectrum disorders, whereas extended synaptic remodeling is thought to underlie circuit dysfunction in schizophrenia. Thus, resolving the mechanisms that instruct critical period timing is important to our understanding of neurodevelopmental disorders. Control of critical period timing is modulated by neuron-intrinsic cues, yet recent data suggest that some determinants are derived from neighboring glial cells (astrocytes, microglia, and oligodendrocytes). As glia make up 50% of the human brain, understanding how these diverse cells communicate with neurons and with each other to sculpt neural plasticity, especially during specialized critical periods, is essential to our fundamental understanding of circuit development and maintenance. |
| first_indexed | 2024-03-11T10:13:37Z |
| format | Article |
| id | doaj.art-3c543d2f10c14ce5bf82b2a07c519c51 |
| institution | Directory Open Access Journal |
| issn | 1662-5102 |
| language | English |
| last_indexed | 2024-03-11T10:13:37Z |
| publishDate | 2023-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj.art-3c543d2f10c14ce5bf82b2a07c519c512023-11-16T12:50:57ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022023-11-011710.3389/fncel.2023.12473351247335Glial regulation of critical period plasticityJacob Starkey0Eric J. Horstick1Eric J. Horstick2Sarah D. Ackerman3Department of Biology, West Virginia University, Morgantown, WV, United StatesDepartment of Biology, West Virginia University, Morgantown, WV, United StatesDepartment of Neuroscience, West Virginia University, Morgantown, WV, United StatesDepartment of Pathology and Immunology, Brain Immunology and Glia Center, Washington University School of Medicine, St. Louis, MO, United StatesAnimal behavior, from simple to complex, is dependent on the faithful wiring of neurons into functional neural circuits. Neural circuits undergo dramatic experience-dependent remodeling during brief developmental windows called critical periods. Environmental experience during critical periods of plasticity produces sustained changes to circuit function and behavior. Precocious critical period closure is linked to autism spectrum disorders, whereas extended synaptic remodeling is thought to underlie circuit dysfunction in schizophrenia. Thus, resolving the mechanisms that instruct critical period timing is important to our understanding of neurodevelopmental disorders. Control of critical period timing is modulated by neuron-intrinsic cues, yet recent data suggest that some determinants are derived from neighboring glial cells (astrocytes, microglia, and oligodendrocytes). As glia make up 50% of the human brain, understanding how these diverse cells communicate with neurons and with each other to sculpt neural plasticity, especially during specialized critical periods, is essential to our fundamental understanding of circuit development and maintenance.https://www.frontiersin.org/articles/10.3389/fncel.2023.1247335/fullcritical period plasticityastrocyteoligodendrocytemicrogliapruningextracellular matrix |
| spellingShingle | Jacob Starkey Eric J. Horstick Eric J. Horstick Sarah D. Ackerman Glial regulation of critical period plasticity Frontiers in Cellular Neuroscience critical period plasticity astrocyte oligodendrocyte microglia pruning extracellular matrix |
| title | Glial regulation of critical period plasticity |
| title_full | Glial regulation of critical period plasticity |
| title_fullStr | Glial regulation of critical period plasticity |
| title_full_unstemmed | Glial regulation of critical period plasticity |
| title_short | Glial regulation of critical period plasticity |
| title_sort | glial regulation of critical period plasticity |
| topic | critical period plasticity astrocyte oligodendrocyte microglia pruning extracellular matrix |
| url | https://www.frontiersin.org/articles/10.3389/fncel.2023.1247335/full |
| work_keys_str_mv | AT jacobstarkey glialregulationofcriticalperiodplasticity AT ericjhorstick glialregulationofcriticalperiodplasticity AT ericjhorstick glialregulationofcriticalperiodplasticity AT sarahdackerman glialregulationofcriticalperiodplasticity |