Extended Neonatal Jaundice Associated with Congenital Myxedema
Congenital hypothyroidism/ myxedema is inadequate thyroid hormone production in newborn infants. This can occur because of an anatomic defect in the gland, an inborn error of thyroid metabolism, iodine deficiency. There is an inverse relationship between age at diagnosis and intelligence quotient (I...
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| Format: | Article |
| Language: | English |
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Romanian Society of Oral Rehabilitation
2012-07-01
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| Series: | Romanian Journal of Oral Rehabilitation |
| Subjects: | |
| Online Access: | http://www.rjor.ro/extended-neonatal-jaundice-associated-with-congenital-myxedema/?lang=ro |
| _version_ | 1819062049285603328 |
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| author | Claudia Olaru Maria Florea Anamaria Burlea Gabriela Paduraru Valeriu V. Lupu Smaranda Diaconescu |
| author_facet | Claudia Olaru Maria Florea Anamaria Burlea Gabriela Paduraru Valeriu V. Lupu Smaranda Diaconescu |
| author_sort | Claudia Olaru |
| collection | DOAJ |
| description | Congenital hypothyroidism/ myxedema is inadequate thyroid hormone production in newborn infants. This can occur because of an anatomic defect in the gland, an inborn error of thyroid metabolism, iodine deficiency. There is an inverse relationship between age at diagnosis and intelligence quotient (IQ) later in life. Most newborn babies with congenital hypothyroidism have few or no clinical manifestations of thyroid deficiency, and the majority of cases are sporadic. Female infant, aged 21 days, is hospitalized in our clinic for investigations, presenting prolonged jaundice. Clinical examination on admission revealed skin and mucous jaundice, throat congestion, nasal obstruction, discrete macroglossia with tongue protrusion. Laboratory investigations revealed predominant indirect hyperbilirubinemia, increased hepatic cytolysis tests. Toxoplasma infectious mononucleosis and cytomegalovirus antibodies were normal. Investigation of thyroid function revealed low FT4 and TSH increased. Endocrinological examination established diagnosis of hypothiroidism |
| first_indexed | 2024-12-21T14:52:36Z |
| format | Article |
| id | doaj.art-3c54c9430e2c4c7bb405364b2545f01a |
| institution | Directory Open Access Journal |
| issn | 2066-7000 2601-4661 |
| language | English |
| last_indexed | 2024-12-21T14:52:36Z |
| publishDate | 2012-07-01 |
| publisher | Romanian Society of Oral Rehabilitation |
| record_format | Article |
| series | Romanian Journal of Oral Rehabilitation |
| spelling | doaj.art-3c54c9430e2c4c7bb405364b2545f01a2022-12-21T18:59:51ZengRomanian Society of Oral RehabilitationRomanian Journal of Oral Rehabilitation2066-70002601-46612012-07-0142103106Extended Neonatal Jaundice Associated with Congenital MyxedemaClaudia Olaru0Maria Florea1Anamaria Burlea2Gabriela Paduraru3Valeriu V. Lupu4Smaranda Diaconescu5Clinic V Pediatrics, "Sf. Maria" Children's Hospital Iasi, University of Medicine and Pharmacy "Grigore T. Popa" - Iasi, RomaniaClinic V Pediatrics, "Sf. Maria" Children's Hospital Iasi, RomaniaSocola Hospital of Psychiatry, Iasi, University of Medicine and Pharmacy "Grigore T. Popa" - Iasi, RomaniaClinic V Pediatrics, "Sf. Maria" Children's Hospital Iasi, University of Medicine and Pharmacy "Grigore T. Popa" - Iasi, RomaniaClinic V Pediatrics, "Sf. Maria" Children's Hospital Iasi, University of Medicine and Pharmacy "Grigore T. Popa" - Iasi, RomaniaClinic V Pediatrics, "Sf. Maria" Children's Hospital Iasi, University of Medicine and Pharmacy "Grigore T. Popa" - Iasi, RomaniaCongenital hypothyroidism/ myxedema is inadequate thyroid hormone production in newborn infants. This can occur because of an anatomic defect in the gland, an inborn error of thyroid metabolism, iodine deficiency. There is an inverse relationship between age at diagnosis and intelligence quotient (IQ) later in life. Most newborn babies with congenital hypothyroidism have few or no clinical manifestations of thyroid deficiency, and the majority of cases are sporadic. Female infant, aged 21 days, is hospitalized in our clinic for investigations, presenting prolonged jaundice. Clinical examination on admission revealed skin and mucous jaundice, throat congestion, nasal obstruction, discrete macroglossia with tongue protrusion. Laboratory investigations revealed predominant indirect hyperbilirubinemia, increased hepatic cytolysis tests. Toxoplasma infectious mononucleosis and cytomegalovirus antibodies were normal. Investigation of thyroid function revealed low FT4 and TSH increased. Endocrinological examination established diagnosis of hypothiroidismhttp://www.rjor.ro/extended-neonatal-jaundice-associated-with-congenital-myxedema/?lang=rocongenital mixedemajaundicethyroid hormone |
| spellingShingle | Claudia Olaru Maria Florea Anamaria Burlea Gabriela Paduraru Valeriu V. Lupu Smaranda Diaconescu Extended Neonatal Jaundice Associated with Congenital Myxedema Romanian Journal of Oral Rehabilitation congenital mixedema jaundice thyroid hormone |
| title | Extended Neonatal Jaundice Associated with Congenital Myxedema |
| title_full | Extended Neonatal Jaundice Associated with Congenital Myxedema |
| title_fullStr | Extended Neonatal Jaundice Associated with Congenital Myxedema |
| title_full_unstemmed | Extended Neonatal Jaundice Associated with Congenital Myxedema |
| title_short | Extended Neonatal Jaundice Associated with Congenital Myxedema |
| title_sort | extended neonatal jaundice associated with congenital myxedema |
| topic | congenital mixedema jaundice thyroid hormone |
| url | http://www.rjor.ro/extended-neonatal-jaundice-associated-with-congenital-myxedema/?lang=ro |
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