Cellular Imaging: a Key Phenotypic Screening Strategy for Predictive Toxicology
Incorporating phenotypic screening as a key strategy will enhances confidence in the predictivity and translatability of drug discovery efforts. Cellular imaging serves as the a phenotypic anchor to identify important toxicologic pathology that encompasses an array of underlying mechanisms, thus pro...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2015-09-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fphar.2015.00191/full |
| Summary: | Incorporating phenotypic screening as a key strategy will enhances confidence in the predictivity and translatability of drug discovery efforts. Cellular imaging serves as the a phenotypic anchor to identify important toxicologic pathology that encompasses an array of underlying mechanisms, thus provides an effective means to reduce drug development failures due to insufficient safety. This mini-review highlights the latest advances in hepatotoxicity, cardiotoxicity, and genetic toxicity tests that utilized cellular imaging as a screening strategy, and recommends path forward for further improvement. |
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| ISSN: | 1663-9812 |