Cellular Imaging: a Key Phenotypic Screening Strategy for Predictive Toxicology
Incorporating phenotypic screening as a key strategy will enhances confidence in the predictivity and translatability of drug discovery efforts. Cellular imaging serves as the a phenotypic anchor to identify important toxicologic pathology that encompasses an array of underlying mechanisms, thus pro...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2015-09-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fphar.2015.00191/full |
| _version_ | 1818238678631186432 |
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| author | JINGHAI JAMES XU |
| author_facet | JINGHAI JAMES XU |
| author_sort | JINGHAI JAMES XU |
| collection | DOAJ |
| description | Incorporating phenotypic screening as a key strategy will enhances confidence in the predictivity and translatability of drug discovery efforts. Cellular imaging serves as the a phenotypic anchor to identify important toxicologic pathology that encompasses an array of underlying mechanisms, thus provides an effective means to reduce drug development failures due to insufficient safety. This mini-review highlights the latest advances in hepatotoxicity, cardiotoxicity, and genetic toxicity tests that utilized cellular imaging as a screening strategy, and recommends path forward for further improvement. |
| first_indexed | 2024-12-12T12:45:28Z |
| format | Article |
| id | doaj.art-3c55e234ae2f43d39c4b7aa43948f2b4 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-12T12:45:28Z |
| publishDate | 2015-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-3c55e234ae2f43d39c4b7aa43948f2b42022-12-22T00:24:08ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122015-09-01610.3389/fphar.2015.00191154193Cellular Imaging: a Key Phenotypic Screening Strategy for Predictive ToxicologyJINGHAI JAMES XU0Merck/MSDIncorporating phenotypic screening as a key strategy will enhances confidence in the predictivity and translatability of drug discovery efforts. Cellular imaging serves as the a phenotypic anchor to identify important toxicologic pathology that encompasses an array of underlying mechanisms, thus provides an effective means to reduce drug development failures due to insufficient safety. This mini-review highlights the latest advances in hepatotoxicity, cardiotoxicity, and genetic toxicity tests that utilized cellular imaging as a screening strategy, and recommends path forward for further improvement.http://journal.frontiersin.org/Journal/10.3389/fphar.2015.00191/fullcardiotoxicityCellular ImagingDiscovery toxicologyGenetic ToxicologyHepatotoxicitypredictive toxicology |
| spellingShingle | JINGHAI JAMES XU Cellular Imaging: a Key Phenotypic Screening Strategy for Predictive Toxicology Frontiers in Pharmacology cardiotoxicity Cellular Imaging Discovery toxicology Genetic Toxicology Hepatotoxicity predictive toxicology |
| title | Cellular Imaging: a Key Phenotypic Screening Strategy for Predictive Toxicology |
| title_full | Cellular Imaging: a Key Phenotypic Screening Strategy for Predictive Toxicology |
| title_fullStr | Cellular Imaging: a Key Phenotypic Screening Strategy for Predictive Toxicology |
| title_full_unstemmed | Cellular Imaging: a Key Phenotypic Screening Strategy for Predictive Toxicology |
| title_short | Cellular Imaging: a Key Phenotypic Screening Strategy for Predictive Toxicology |
| title_sort | cellular imaging a key phenotypic screening strategy for predictive toxicology |
| topic | cardiotoxicity Cellular Imaging Discovery toxicology Genetic Toxicology Hepatotoxicity predictive toxicology |
| url | http://journal.frontiersin.org/Journal/10.3389/fphar.2015.00191/full |
| work_keys_str_mv | AT jinghaijamesxu cellularimagingakeyphenotypicscreeningstrategyforpredictivetoxicology |