Hypoglycemic and Anti-Inflammatory Effects of Triterpene Glycoside Fractions from <i>Aeculus hippocastanum</i> Seeds
Horse chestnut (<i>Aesculus hippocastanum</i> L.)-derived drugs have shown their potential in biomedical applications. The seed of <i>A. hippocastanum</i> contains various kinds of chemical compounds including phenolics, flavonoids, coumarins, and triterpene saponins. Here, w...
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| Format: | Article |
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MDPI AG
2021-06-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/26/13/3784 |
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| author | Avez Sharipov Khurshid Tursunov Sunnatullo Fazliev Bahtigul Azimova Jamoliddin Razzokov |
| author_facet | Avez Sharipov Khurshid Tursunov Sunnatullo Fazliev Bahtigul Azimova Jamoliddin Razzokov |
| author_sort | Avez Sharipov |
| collection | DOAJ |
| description | Horse chestnut (<i>Aesculus hippocastanum</i> L.)-derived drugs have shown their potential in biomedical applications. The seed of <i>A. hippocastanum</i> contains various kinds of chemical compounds including phenolics, flavonoids, coumarins, and triterpene saponins. Here, we investigated the chemical components in <i>A. hippocastanum</i> L. grown in Uzbekistan, which has not yet been studied in detail. We identified 30 kinds of triterpene saponins in an extract of <i>A. hippocastanum</i> L. Classifying extracted saponins into eight fractions, we next studied the hypoglycemic and the anti-inflammatory activities of escin and its derivatives through in vivo experiments. We came by data indicating the highest (SF-1 and SF-2) and the lowest (SF-5 and SF-8) antidiabetic and anti-inflammatory effects of those eight fractions. These results imply the prospective use of <i>A. hippocastanum</i> L. grown in Uzbekistan in the production of pharmaceutical drugs to treat diabetes and inflammation. |
| first_indexed | 2024-03-10T10:11:31Z |
| format | Article |
| id | doaj.art-3c5664b5508940edbffd9b1bfd764289 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T10:11:31Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-3c5664b5508940edbffd9b1bfd7642892023-11-22T01:09:32ZengMDPI AGMolecules1420-30492021-06-012613378410.3390/molecules26133784Hypoglycemic and Anti-Inflammatory Effects of Triterpene Glycoside Fractions from <i>Aeculus hippocastanum</i> SeedsAvez Sharipov0Khurshid Tursunov1Sunnatullo Fazliev2Bahtigul Azimova3Jamoliddin Razzokov4Department of Inorganic, Physical and Colloidal Chemistry, Tashkent Pharmaceutical Institute, Oybek Street 45, Tashkent 100015, UzbekistanDepartment of Inorganic, Physical and Colloidal Chemistry, Tashkent Pharmaceutical Institute, Oybek Street 45, Tashkent 100015, UzbekistanMax Planck School Matter to Life, Jahnstrasse 29, 69120 Heidelberg, GermanyDepartment of Inorganic, Physical and Colloidal Chemistry, Tashkent Pharmaceutical Institute, Oybek Street 45, Tashkent 100015, UzbekistanDepartment of Physics and Chemistry, Tashkent Institute of Irrigation and Agricultural Mechanization Engineers, Kori Niyoziy 39, Tashkent 100000, UzbekistanHorse chestnut (<i>Aesculus hippocastanum</i> L.)-derived drugs have shown their potential in biomedical applications. The seed of <i>A. hippocastanum</i> contains various kinds of chemical compounds including phenolics, flavonoids, coumarins, and triterpene saponins. Here, we investigated the chemical components in <i>A. hippocastanum</i> L. grown in Uzbekistan, which has not yet been studied in detail. We identified 30 kinds of triterpene saponins in an extract of <i>A. hippocastanum</i> L. Classifying extracted saponins into eight fractions, we next studied the hypoglycemic and the anti-inflammatory activities of escin and its derivatives through in vivo experiments. We came by data indicating the highest (SF-1 and SF-2) and the lowest (SF-5 and SF-8) antidiabetic and anti-inflammatory effects of those eight fractions. These results imply the prospective use of <i>A. hippocastanum</i> L. grown in Uzbekistan in the production of pharmaceutical drugs to treat diabetes and inflammation.https://www.mdpi.com/1420-3049/26/13/3784chestnutsaponinescinbiological activitydiabetesinflammation |
| spellingShingle | Avez Sharipov Khurshid Tursunov Sunnatullo Fazliev Bahtigul Azimova Jamoliddin Razzokov Hypoglycemic and Anti-Inflammatory Effects of Triterpene Glycoside Fractions from <i>Aeculus hippocastanum</i> Seeds Molecules chestnut saponin escin biological activity diabetes inflammation |
| title | Hypoglycemic and Anti-Inflammatory Effects of Triterpene Glycoside Fractions from <i>Aeculus hippocastanum</i> Seeds |
| title_full | Hypoglycemic and Anti-Inflammatory Effects of Triterpene Glycoside Fractions from <i>Aeculus hippocastanum</i> Seeds |
| title_fullStr | Hypoglycemic and Anti-Inflammatory Effects of Triterpene Glycoside Fractions from <i>Aeculus hippocastanum</i> Seeds |
| title_full_unstemmed | Hypoglycemic and Anti-Inflammatory Effects of Triterpene Glycoside Fractions from <i>Aeculus hippocastanum</i> Seeds |
| title_short | Hypoglycemic and Anti-Inflammatory Effects of Triterpene Glycoside Fractions from <i>Aeculus hippocastanum</i> Seeds |
| title_sort | hypoglycemic and anti inflammatory effects of triterpene glycoside fractions from i aeculus hippocastanum i seeds |
| topic | chestnut saponin escin biological activity diabetes inflammation |
| url | https://www.mdpi.com/1420-3049/26/13/3784 |
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