Preventive effect of small‐leaved Kuding tea (Ligustrum robustum) on high‐diet‐induced obesity in C57BL/6J mice
Abstract Small‐leaved Kuding tea (SLKDT; Ligustrum robustum) is a traditional Chinese tea. We systematically investigated the effect of SLKDT extract on obesity. SLKDT‐controlled weight gain in mice fed a high‐fat diet. Tissue specimen results showed that the SLKDT extract alleviated liver damage an...
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| Format: | Article |
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Wiley
2020-08-01
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| Series: | Food Science & Nutrition |
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| Online Access: | https://doi.org/10.1002/fsn3.1758 |
| _version_ | 1797661238986014720 |
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| author | Ya Wu Jun Yang Xiaojing Liu Ying Zhang Ailing Lei Ruokun Yi Fang Tan Xin Zhao |
| author_facet | Ya Wu Jun Yang Xiaojing Liu Ying Zhang Ailing Lei Ruokun Yi Fang Tan Xin Zhao |
| author_sort | Ya Wu |
| collection | DOAJ |
| description | Abstract Small‐leaved Kuding tea (SLKDT; Ligustrum robustum) is a traditional Chinese tea. We systematically investigated the effect of SLKDT extract on obesity. SLKDT‐controlled weight gain in mice fed a high‐fat diet. Tissue specimen results showed that the SLKDT extract alleviated liver damage and fat accumulation. Meanwhile, SLKDT extract improved dyslipidemia by decreasing total cholesterol, triglycerides, and low‐density lipoprotein cholesterol levels and increasing high‐density lipoprotein cholesterol levels. Furthermore, SLKDT extract reduced alanine aminotransferase, alkaline phosphatase, and aspartate transaminase levels in the serum and liver tissues; decreased inflammatory cytokines, including interleukin (IL)‐1β, tumor necrosis factor‐α, interferon‐γ, and IL‐6; and increased the anti‐inflammatory cytokines, IL‐4 and IL‐10. The quantitative PCR results showed that SLKDT extract upregulated the mRNA expressions of peroxisome proliferator‐activated receptor (PPAR)‐α, lipoprotein lipase, carnitine palmitoyltransferase 1, and cholesterol 7 alpha hydroxylase and downregulated PPAR‐γ and CCAAT/enhancer‐binding protein‐alpha mRNA expressions in the obese mouse livers to reduce adipocyte differentiation and fat accumulation, promote fat oxidation, and improve dyslipidemia, thereby inhibiting the immune response and alleviating liver injury. SLKDT shows a potential for preventing obesity and regulating obesity‐related syndrome, so it is possible to be further developed as a novel treatment for fighting obesity. |
| first_indexed | 2024-03-11T18:41:32Z |
| format | Article |
| id | doaj.art-3c5670e546d747a6847c30ebcfd42876 |
| institution | Directory Open Access Journal |
| issn | 2048-7177 |
| language | English |
| last_indexed | 2024-03-11T18:41:32Z |
| publishDate | 2020-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | Food Science & Nutrition |
| spelling | doaj.art-3c5670e546d747a6847c30ebcfd428762023-10-12T12:06:11ZengWileyFood Science & Nutrition2048-71772020-08-01884512452210.1002/fsn3.1758Preventive effect of small‐leaved Kuding tea (Ligustrum robustum) on high‐diet‐induced obesity in C57BL/6J miceYa Wu0Jun Yang1Xiaojing Liu2Ying Zhang3Ailing Lei4Ruokun Yi5Fang Tan6Xin Zhao7Chongqing Collaborative Innovation Center for Functional Food Chongqing University of Education Chongqing ChinaDepartment of Gastroenterology People's Hospital of Chongqing Banan District Chongqing ChinaChongqing Collaborative Innovation Center for Functional Food Chongqing University of Education Chongqing ChinaChongqing Collaborative Innovation Center for Functional Food Chongqing University of Education Chongqing ChinaChongqing Collaborative Innovation Center for Functional Food Chongqing University of Education Chongqing ChinaChongqing Collaborative Innovation Center for Functional Food Chongqing University of Education Chongqing ChinaDepartment of Public Health Our Lady of Fatima University Valenzuela PhilippinesChongqing Collaborative Innovation Center for Functional Food Chongqing University of Education Chongqing ChinaAbstract Small‐leaved Kuding tea (SLKDT; Ligustrum robustum) is a traditional Chinese tea. We systematically investigated the effect of SLKDT extract on obesity. SLKDT‐controlled weight gain in mice fed a high‐fat diet. Tissue specimen results showed that the SLKDT extract alleviated liver damage and fat accumulation. Meanwhile, SLKDT extract improved dyslipidemia by decreasing total cholesterol, triglycerides, and low‐density lipoprotein cholesterol levels and increasing high‐density lipoprotein cholesterol levels. Furthermore, SLKDT extract reduced alanine aminotransferase, alkaline phosphatase, and aspartate transaminase levels in the serum and liver tissues; decreased inflammatory cytokines, including interleukin (IL)‐1β, tumor necrosis factor‐α, interferon‐γ, and IL‐6; and increased the anti‐inflammatory cytokines, IL‐4 and IL‐10. The quantitative PCR results showed that SLKDT extract upregulated the mRNA expressions of peroxisome proliferator‐activated receptor (PPAR)‐α, lipoprotein lipase, carnitine palmitoyltransferase 1, and cholesterol 7 alpha hydroxylase and downregulated PPAR‐γ and CCAAT/enhancer‐binding protein‐alpha mRNA expressions in the obese mouse livers to reduce adipocyte differentiation and fat accumulation, promote fat oxidation, and improve dyslipidemia, thereby inhibiting the immune response and alleviating liver injury. SLKDT shows a potential for preventing obesity and regulating obesity‐related syndrome, so it is possible to be further developed as a novel treatment for fighting obesity.https://doi.org/10.1002/fsn3.1758anti‐inflammationanti‐obesityhigh‐fat dietLigustrum robustumlipid metabolismsmall‐leaved Kuding tea |
| spellingShingle | Ya Wu Jun Yang Xiaojing Liu Ying Zhang Ailing Lei Ruokun Yi Fang Tan Xin Zhao Preventive effect of small‐leaved Kuding tea (Ligustrum robustum) on high‐diet‐induced obesity in C57BL/6J mice Food Science & Nutrition anti‐inflammation anti‐obesity high‐fat diet Ligustrum robustum lipid metabolism small‐leaved Kuding tea |
| title | Preventive effect of small‐leaved Kuding tea (Ligustrum robustum) on high‐diet‐induced obesity in C57BL/6J mice |
| title_full | Preventive effect of small‐leaved Kuding tea (Ligustrum robustum) on high‐diet‐induced obesity in C57BL/6J mice |
| title_fullStr | Preventive effect of small‐leaved Kuding tea (Ligustrum robustum) on high‐diet‐induced obesity in C57BL/6J mice |
| title_full_unstemmed | Preventive effect of small‐leaved Kuding tea (Ligustrum robustum) on high‐diet‐induced obesity in C57BL/6J mice |
| title_short | Preventive effect of small‐leaved Kuding tea (Ligustrum robustum) on high‐diet‐induced obesity in C57BL/6J mice |
| title_sort | preventive effect of small leaved kuding tea ligustrum robustum on high diet induced obesity in c57bl 6j mice |
| topic | anti‐inflammation anti‐obesity high‐fat diet Ligustrum robustum lipid metabolism small‐leaved Kuding tea |
| url | https://doi.org/10.1002/fsn3.1758 |
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