Overall and stage-specific survival of patients with screen-detected colorectal cancer in European countries: A population-based study in 9 countries
Summary: Background: An increasing proportion of colorectal cancers (CRCs) are detected through screening due to the availability of organised population-based programmes. We aimed to analyse survival probabilities of patients with screen-detected CRC in European countries. Methods: Data from CRC p...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-10-01
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| Series: | The Lancet Regional Health. Europe |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666776222001521 |
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| author | Rafael Cardoso Feng Guo Thomas Heisser Harlinde De Schutter Nancy Van Damme Mef Christina Nilbert Jane Christensen Anne-Marie Bouvier Véronique Bouvier Guy Launoy Anne-Sophie Woronoff Mélanie Cariou Michel Robaszkiewicz Patricia Delafosse Florence Poncet Paul M. Walsh Carlo Senore Stefano Rosso Valery E.P.P. Lemmens Marloes A.G. Elferink Sonja Tomšič Tina Žagar Arantza Lopez de Munain Marques Rafael Marcos-Gragera Montse Puigdemont Jaume Galceran Marià Carulla Antonia Sánchez-Gil María-Dolores Chirlaque Michael Hoffmeister Hermann Brenner |
| author_facet | Rafael Cardoso Feng Guo Thomas Heisser Harlinde De Schutter Nancy Van Damme Mef Christina Nilbert Jane Christensen Anne-Marie Bouvier Véronique Bouvier Guy Launoy Anne-Sophie Woronoff Mélanie Cariou Michel Robaszkiewicz Patricia Delafosse Florence Poncet Paul M. Walsh Carlo Senore Stefano Rosso Valery E.P.P. Lemmens Marloes A.G. Elferink Sonja Tomšič Tina Žagar Arantza Lopez de Munain Marques Rafael Marcos-Gragera Montse Puigdemont Jaume Galceran Marià Carulla Antonia Sánchez-Gil María-Dolores Chirlaque Michael Hoffmeister Hermann Brenner |
| author_sort | Rafael Cardoso |
| collection | DOAJ |
| description | Summary: Background: An increasing proportion of colorectal cancers (CRCs) are detected through screening due to the availability of organised population-based programmes. We aimed to analyse survival probabilities of patients with screen-detected CRC in European countries. Methods: Data from CRC patients were obtained from 16 population-based cancer registries in nine European countries. We included patients with cancer diagnosed from the year organised CRC screening programmes were introduced until the most recent year with available data at the time of analysis, whose ages at diagnosis fell into the age groups targeted by screening. Patients were followed up with regards to vital status until 2016-2020 across the various countries. Overall and CRC-specific survival were analysed by mode of detection and stage at diagnosis for all countries combined and for each country separately using the Kaplan-Meier method. Findings: We included data from 228 134 patients, of whom 134 597 (aged 60-69 years at diagnosis targeted by screening in all countries) were considered in analyses for all countries combined. 22·3% (38 080/134 597) of patients had cancer detected through screening. Most screen-detected cancers were found at stages I-II (65·6% [12 772/19 469 included in stage-specific analyses]), while the majority of non-screen-detected cancers were found at stages III-IV (56·4% [31 882/56 543 included in stage-specific analyses]). Five-year overall and CRC-specific survival rates for patients with screen-detected cancer were 83·4% (95% CI 82·9-83·9) and 89·2% (88·8-89·7), respectively; for patients with non-screen-detected cancer, they were much lower (57·5% [57·2-57·8] and 65·7% [65·4-66·1], respectively). The favourable survival of patients with screen-detected cancer was also seen within each stage – five-year overall survival rates for patients with screen-detected stage I, II, III, and IV cancers were 92.4% (95% CI 91·6-93·1), 87·9% (86·6-89·1), 80·7% (79·3-82·0), and 32·3 (29·4-35·2), respectively. These patterns were also consistently seen for each individual country. Interpretation: Patients with cancer diagnosed at screening have a very favourable prognosis. In the rare case of detection of advanced stage cancer, survival probabilities are still much higher than those commonly reported for all patients regardless of mode of detection. Although these results cannot be taken to quantify screening effects, they provide useful and encouraging information for patients with screen-detected CRC and their physicians. Funding: This study was supported in part by grants from the German Federal Ministry of Education and Research and the German Cancer Aid. |
| first_indexed | 2024-04-13T14:36:47Z |
| format | Article |
| id | doaj.art-3c5a157a445248329435eb842202ad20 |
| institution | Directory Open Access Journal |
| issn | 2666-7762 |
| language | English |
| last_indexed | 2024-04-13T14:36:47Z |
| publishDate | 2022-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | The Lancet Regional Health. Europe |
| spelling | doaj.art-3c5a157a445248329435eb842202ad202022-12-22T02:43:00ZengElsevierThe Lancet Regional Health. Europe2666-77622022-10-0121100458Overall and stage-specific survival of patients with screen-detected colorectal cancer in European countries: A population-based study in 9 countriesRafael Cardoso0Feng Guo1Thomas Heisser2Harlinde De Schutter3Nancy Van Damme4Mef Christina Nilbert5Jane Christensen6Anne-Marie Bouvier7Véronique Bouvier8Guy Launoy9Anne-Sophie Woronoff10Mélanie Cariou11Michel Robaszkiewicz12Patricia Delafosse13Florence Poncet14Paul M. Walsh15Carlo Senore16Stefano Rosso17Valery E.P.P. Lemmens18Marloes A.G. Elferink19Sonja Tomšič20Tina Žagar21Arantza Lopez de Munain Marques22Rafael Marcos-Gragera23Montse Puigdemont24Jaume Galceran25Marià Carulla26Antonia Sánchez-Gil27María-Dolores Chirlaque28Michael Hoffmeister29Hermann Brenner30Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany; Medical Faculty Heidelberg, University of Heidelberg, Heidelberg, GermanyDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, GermanyMedical Faculty Heidelberg, University of Heidelberg, Heidelberg, Germany; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, GermanyBelgian Cancer Registry, Brussels, BelgiumBelgian Cancer Registry, Brussels, BelgiumDanish Cancer Society Research Center, Copenhagen, Denmark; Hvidovre University Hospital, University of Copenhagen, Copenhagen, DenmarkDanish Cancer Society Research Center, Copenhagen, DenmarkDigestive cancer registry of Burgundy, University Hospital of Dijon, French Network of Cancer Registries (FRANCIM), Inserm, U1231 Dijon, FranceDigestive Tumors Registry of Calvados, University Hospital of Caen, U1086 INSERM UCN - ANTICIPE, French Network of Cancer Registries (FRANCIM), FranceNormandie Univ, UniCaen, Inserm, Anticipe, 14000 Caen, France; University Hospital of Caen, Caen, FranceCancer Registry of Doubs, CHRU Besançon, FranceDigestive Tumors Registry of Finistère, CHRU Morvan, French Network of Cancer Registries (FRANCIM), Brest, FranceDigestive Tumors Registry of Finistère, CHRU Morvan, French Network of Cancer Registries (FRANCIM), Brest, FranceCancer Registry of Isère, French Network of Cancer Registries (FRANCIM), Grenoble, FranceCancer Registry of Isère, French Network of Cancer Registries (FRANCIM), Grenoble, FranceNational Cancer Registry Ireland, Cork, IrelandUniversity Hospital ‘Città della Salute e della Scienza’, SSD Epidemiologia e screening – CPO, Turin, ItalyPiedmont Cancer Registry, Turin, ItalyDepartment of Research and Development, Netherlands Comprehensive Cancer Organisation (IKNL), Utrecht, Netherlands; Department of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam, NetherlandsDepartment of Research and Development, Netherlands Comprehensive Cancer Organisation (IKNL), Utrecht, NetherlandsSlovenian Cancer Registry, Institute of Oncology, Ljubljana, SloveniaSlovenian Cancer Registry, Institute of Oncology, Ljubljana, SloveniaBasque Country Cancer Registry, Vitoria-Gasteiz, SpainEpidemiology Unit and Girona Cancer Registry, Oncology Coordination Plan, Department of Health Government of Catalonia, Catalan Institute of Oncology, Girona, Spain; Descriptive Epidemiology, Genetics and Cancer Prevention Group, Biomedical Research Institute (IDIBGI), Salt, Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública, CIBERESP), Madrid, SpainEpidemiology Unit and Girona Cancer Registry, Oncology Coordination Plan, Department of Health Government of Catalonia, Catalan Institute of Oncology, Girona, Spain; Descriptive Epidemiology, Genetics and Cancer Prevention Group, Biomedical Research Institute (IDIBGI), Salt, SpainTarragona Cancer Registry, Epidemiology and Prevention Cancer Service, Hospital Universitari Sant Joan de Reus, Pere Virgili Health Research Institute (IISPV), Reus, SpainTarragona Cancer Registry, Epidemiology and Prevention Cancer Service, Hospital Universitari Sant Joan de Reus, Pere Virgili Health Research Institute (IISPV), Reus, SpainDepartment of Epidemiology, Regional Health Council, IMIB-Arrixaca, Murcia, SpainConsortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública, CIBERESP), Madrid, Spain; Department of Epidemiology, Regional Health Council, IMIB-Arrixaca, Murcia, Spain; Department of Health and Social Sciences, Universidad de Murcia, Murcia, SpainDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, GermanyDivision of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany; Corresponding author at: Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, 69120 Heidelberg, Germany.Summary: Background: An increasing proportion of colorectal cancers (CRCs) are detected through screening due to the availability of organised population-based programmes. We aimed to analyse survival probabilities of patients with screen-detected CRC in European countries. Methods: Data from CRC patients were obtained from 16 population-based cancer registries in nine European countries. We included patients with cancer diagnosed from the year organised CRC screening programmes were introduced until the most recent year with available data at the time of analysis, whose ages at diagnosis fell into the age groups targeted by screening. Patients were followed up with regards to vital status until 2016-2020 across the various countries. Overall and CRC-specific survival were analysed by mode of detection and stage at diagnosis for all countries combined and for each country separately using the Kaplan-Meier method. Findings: We included data from 228 134 patients, of whom 134 597 (aged 60-69 years at diagnosis targeted by screening in all countries) were considered in analyses for all countries combined. 22·3% (38 080/134 597) of patients had cancer detected through screening. Most screen-detected cancers were found at stages I-II (65·6% [12 772/19 469 included in stage-specific analyses]), while the majority of non-screen-detected cancers were found at stages III-IV (56·4% [31 882/56 543 included in stage-specific analyses]). Five-year overall and CRC-specific survival rates for patients with screen-detected cancer were 83·4% (95% CI 82·9-83·9) and 89·2% (88·8-89·7), respectively; for patients with non-screen-detected cancer, they were much lower (57·5% [57·2-57·8] and 65·7% [65·4-66·1], respectively). The favourable survival of patients with screen-detected cancer was also seen within each stage – five-year overall survival rates for patients with screen-detected stage I, II, III, and IV cancers were 92.4% (95% CI 91·6-93·1), 87·9% (86·6-89·1), 80·7% (79·3-82·0), and 32·3 (29·4-35·2), respectively. These patterns were also consistently seen for each individual country. Interpretation: Patients with cancer diagnosed at screening have a very favourable prognosis. In the rare case of detection of advanced stage cancer, survival probabilities are still much higher than those commonly reported for all patients regardless of mode of detection. Although these results cannot be taken to quantify screening effects, they provide useful and encouraging information for patients with screen-detected CRC and their physicians. Funding: This study was supported in part by grants from the German Federal Ministry of Education and Research and the German Cancer Aid.http://www.sciencedirect.com/science/article/pii/S2666776222001521Colorectal cancerSurvivalScreeningEurope |
| spellingShingle | Rafael Cardoso Feng Guo Thomas Heisser Harlinde De Schutter Nancy Van Damme Mef Christina Nilbert Jane Christensen Anne-Marie Bouvier Véronique Bouvier Guy Launoy Anne-Sophie Woronoff Mélanie Cariou Michel Robaszkiewicz Patricia Delafosse Florence Poncet Paul M. Walsh Carlo Senore Stefano Rosso Valery E.P.P. Lemmens Marloes A.G. Elferink Sonja Tomšič Tina Žagar Arantza Lopez de Munain Marques Rafael Marcos-Gragera Montse Puigdemont Jaume Galceran Marià Carulla Antonia Sánchez-Gil María-Dolores Chirlaque Michael Hoffmeister Hermann Brenner Overall and stage-specific survival of patients with screen-detected colorectal cancer in European countries: A population-based study in 9 countries The Lancet Regional Health. Europe Colorectal cancer Survival Screening Europe |
| title | Overall and stage-specific survival of patients with screen-detected colorectal cancer in European countries: A population-based study in 9 countries |
| title_full | Overall and stage-specific survival of patients with screen-detected colorectal cancer in European countries: A population-based study in 9 countries |
| title_fullStr | Overall and stage-specific survival of patients with screen-detected colorectal cancer in European countries: A population-based study in 9 countries |
| title_full_unstemmed | Overall and stage-specific survival of patients with screen-detected colorectal cancer in European countries: A population-based study in 9 countries |
| title_short | Overall and stage-specific survival of patients with screen-detected colorectal cancer in European countries: A population-based study in 9 countries |
| title_sort | overall and stage specific survival of patients with screen detected colorectal cancer in european countries a population based study in 9 countries |
| topic | Colorectal cancer Survival Screening Europe |
| url | http://www.sciencedirect.com/science/article/pii/S2666776222001521 |
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