Sporadic Creutzfeldt–Jakob disease infected human cerebral organoids retain the original human brain subtype features following transmission to humanized transgenic mice

Sporadic Creutzfeldt–Jakob disease infected human cerebral organoids retain the original human brain subtype features following transmission to humanized transgenic mice

Abstract Human cerebral organoids (COs) are three-dimensional self-organizing cultures of cerebral brain tissue differentiated from induced pluripotent stem cells. We have recently shown that COs are susceptible to infection with different subtypes of Creutzfeldt–Jakob disease (CJD) prions, which in...

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Bibliographic Details
Main Authors: Bradley R. Groveman, Brent Race, Simote T. Foliaki, Katie Williams, Andrew G. Hughson, Chase Baune, Gianluigi Zanusso, Cathryn L. Haigh
Format: Article
Language:English
Published: BMC 2023-02-01
Series:Acta Neuropathologica Communications
Subjects:
Sporadic CJD
Subtype
Prion
PrP
Cerebral organoid
Online Access:https://doi.org/10.1186/s40478-023-01512-1

Internet

https://doi.org/10.1186/s40478-023-01512-1

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