Synergistic Interaction and Binding Efficiency of Tetracaine Hydrochloride (Anesthetic Drug) with Anionic Surfactants in the Presence of NaCl Solution Using Surface Tension and UV–Visible Spectroscopic Methods
Surfactants are ubiquitous materials that are used in diverse formulations of various products. For instance, they improve the formulation of gel by improving its wetting and rheological properties. Here, we describe the effects of anionic surfactants on an anesthetic drug, tetracaine hydrochloride...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-04-01
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| Series: | Gels |
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| Online Access: | https://www.mdpi.com/2310-2861/8/4/234 |
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| author | Naved Azum Malik Abdul Rub Anish Khan Maha M. Alotaibi Abdullah M. Asiri |
| author_facet | Naved Azum Malik Abdul Rub Anish Khan Maha M. Alotaibi Abdullah M. Asiri |
| author_sort | Naved Azum |
| collection | DOAJ |
| description | Surfactants are ubiquitous materials that are used in diverse formulations of various products. For instance, they improve the formulation of gel by improving its wetting and rheological properties. Here, we describe the effects of anionic surfactants on an anesthetic drug, tetracaine hydrochloride (TCH), in NaCl solution with tensiometry and UV–visible techniques. Various micellar, interfacial, and thermodynamic parameters were estimated. The outputs were examined by using different theoretical models to attain a profound knowledge of drug–surfactant mixtures. The presence of attractive interactions among drug and surfactant monomers (synergism) in mixed micelle was inferred. However, it was found that sodium dodecyl sulfate (SDS) showed greater interactions with the drug in comparison to sodium lauryl sarcosine (SLS). The binding of the drug with surfactants was monitored with a spectroscopic technique (UV–visible spectra). The results of this study could help optimize the compositions of these mixed aggregates and find the synergism between monomers of different used amphiphiles. |
| first_indexed | 2024-03-09T13:39:12Z |
| format | Article |
| id | doaj.art-3c5c09f0e33244618ef10fa8f6337246 |
| institution | Directory Open Access Journal |
| issn | 2310-2861 |
| language | English |
| last_indexed | 2024-03-09T13:39:12Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Gels |
| spelling | doaj.art-3c5c09f0e33244618ef10fa8f63372462023-11-30T21:09:17ZengMDPI AGGels2310-28612022-04-018423410.3390/gels8040234Synergistic Interaction and Binding Efficiency of Tetracaine Hydrochloride (Anesthetic Drug) with Anionic Surfactants in the Presence of NaCl Solution Using Surface Tension and UV–Visible Spectroscopic MethodsNaved Azum0Malik Abdul Rub1Anish Khan2Maha M. Alotaibi3Abdullah M. Asiri4Center of Excellence for Advanced Materials Research, King Abdulaziz University, Jeddah 21589, Saudi ArabiaCenter of Excellence for Advanced Materials Research, King Abdulaziz University, Jeddah 21589, Saudi ArabiaCenter of Excellence for Advanced Materials Research, King Abdulaziz University, Jeddah 21589, Saudi ArabiaChemistry Department, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi ArabiaCenter of Excellence for Advanced Materials Research, King Abdulaziz University, Jeddah 21589, Saudi ArabiaSurfactants are ubiquitous materials that are used in diverse formulations of various products. For instance, they improve the formulation of gel by improving its wetting and rheological properties. Here, we describe the effects of anionic surfactants on an anesthetic drug, tetracaine hydrochloride (TCH), in NaCl solution with tensiometry and UV–visible techniques. Various micellar, interfacial, and thermodynamic parameters were estimated. The outputs were examined by using different theoretical models to attain a profound knowledge of drug–surfactant mixtures. The presence of attractive interactions among drug and surfactant monomers (synergism) in mixed micelle was inferred. However, it was found that sodium dodecyl sulfate (SDS) showed greater interactions with the drug in comparison to sodium lauryl sarcosine (SLS). The binding of the drug with surfactants was monitored with a spectroscopic technique (UV–visible spectra). The results of this study could help optimize the compositions of these mixed aggregates and find the synergism between monomers of different used amphiphiles.https://www.mdpi.com/2310-2861/8/4/234tetracaine hydrochloridesodium dodecyl sulfatesodium lauroyl sarcosinedrug–surfactant mixed micellesynergistic interaction |
| spellingShingle | Naved Azum Malik Abdul Rub Anish Khan Maha M. Alotaibi Abdullah M. Asiri Synergistic Interaction and Binding Efficiency of Tetracaine Hydrochloride (Anesthetic Drug) with Anionic Surfactants in the Presence of NaCl Solution Using Surface Tension and UV–Visible Spectroscopic Methods Gels tetracaine hydrochloride sodium dodecyl sulfate sodium lauroyl sarcosine drug–surfactant mixed micelle synergistic interaction |
| title | Synergistic Interaction and Binding Efficiency of Tetracaine Hydrochloride (Anesthetic Drug) with Anionic Surfactants in the Presence of NaCl Solution Using Surface Tension and UV–Visible Spectroscopic Methods |
| title_full | Synergistic Interaction and Binding Efficiency of Tetracaine Hydrochloride (Anesthetic Drug) with Anionic Surfactants in the Presence of NaCl Solution Using Surface Tension and UV–Visible Spectroscopic Methods |
| title_fullStr | Synergistic Interaction and Binding Efficiency of Tetracaine Hydrochloride (Anesthetic Drug) with Anionic Surfactants in the Presence of NaCl Solution Using Surface Tension and UV–Visible Spectroscopic Methods |
| title_full_unstemmed | Synergistic Interaction and Binding Efficiency of Tetracaine Hydrochloride (Anesthetic Drug) with Anionic Surfactants in the Presence of NaCl Solution Using Surface Tension and UV–Visible Spectroscopic Methods |
| title_short | Synergistic Interaction and Binding Efficiency of Tetracaine Hydrochloride (Anesthetic Drug) with Anionic Surfactants in the Presence of NaCl Solution Using Surface Tension and UV–Visible Spectroscopic Methods |
| title_sort | synergistic interaction and binding efficiency of tetracaine hydrochloride anesthetic drug with anionic surfactants in the presence of nacl solution using surface tension and uv visible spectroscopic methods |
| topic | tetracaine hydrochloride sodium dodecyl sulfate sodium lauroyl sarcosine drug–surfactant mixed micelle synergistic interaction |
| url | https://www.mdpi.com/2310-2861/8/4/234 |
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