Moles of Molecules against <i>Mycobacterium abscessus</i>: A Review of Current Research
<i>Mycobacterium abscessus</i> is an emerging opportunistic pathogen that infects mainly the respiratory tract of individuals with pre-existing clinical pictures. In recent years, the incidence of infections of this microorganism has risen, in particular in patients with cystic fibrosis,...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-09-01
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| Series: | Future Pharmacology |
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| Online Access: | https://www.mdpi.com/2673-9879/3/3/41 |
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| author | Mario Cocorullo Christian Bettoni Sara Foiadelli Giovanni Stelitano |
| author_facet | Mario Cocorullo Christian Bettoni Sara Foiadelli Giovanni Stelitano |
| author_sort | Mario Cocorullo |
| collection | DOAJ |
| description | <i>Mycobacterium abscessus</i> is an emerging opportunistic pathogen that infects mainly the respiratory tract of individuals with pre-existing clinical pictures. In recent years, the incidence of infections of this microorganism has risen, in particular in patients with cystic fibrosis, leading to an exacerbation of their conditions. The actual therapeutic regimen has low efficacy and is extended for long periods since it is mainly based on a combination of repurposed drugs, generally from treatments of <i>Mycobacterium tuberculosis</i> infections. For this reason, it is necessary to develop new drugs or alternative strategies in order to improve the efficacy and shorten the time of treatments. This review aims to give an overview of drugs in the pre-clinical and clinical phases of evaluation against <i>M. abscessus</i> and the molecules that have been in development for the past five years in the early drug-discovery phase. |
| first_indexed | 2024-03-10T22:44:08Z |
| format | Article |
| id | doaj.art-3c5da4022a8d4cdaaa467c669dc267ae |
| institution | Directory Open Access Journal |
| issn | 2673-9879 |
| language | English |
| last_indexed | 2024-03-10T22:44:08Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Future Pharmacology |
| spelling | doaj.art-3c5da4022a8d4cdaaa467c669dc267ae2023-11-19T10:49:38ZengMDPI AGFuture Pharmacology2673-98792023-09-013363766310.3390/futurepharmacol3030041Moles of Molecules against <i>Mycobacterium abscessus</i>: A Review of Current ResearchMario Cocorullo0Christian Bettoni1Sara Foiadelli2Giovanni Stelitano3Department of Biology and Biotechnology “Lazzaro Spallanzani”, University of Pavia, Via A. Ferrata 9, 27100 Pavia, ItalyDepartment of Biology and Biotechnology “Lazzaro Spallanzani”, University of Pavia, Via A. Ferrata 9, 27100 Pavia, ItalyDepartment of Biology and Biotechnology “Lazzaro Spallanzani”, University of Pavia, Via A. Ferrata 9, 27100 Pavia, ItalyDepartment of Biology and Biotechnology “Lazzaro Spallanzani”, University of Pavia, Via A. Ferrata 9, 27100 Pavia, Italy<i>Mycobacterium abscessus</i> is an emerging opportunistic pathogen that infects mainly the respiratory tract of individuals with pre-existing clinical pictures. In recent years, the incidence of infections of this microorganism has risen, in particular in patients with cystic fibrosis, leading to an exacerbation of their conditions. The actual therapeutic regimen has low efficacy and is extended for long periods since it is mainly based on a combination of repurposed drugs, generally from treatments of <i>Mycobacterium tuberculosis</i> infections. For this reason, it is necessary to develop new drugs or alternative strategies in order to improve the efficacy and shorten the time of treatments. This review aims to give an overview of drugs in the pre-clinical and clinical phases of evaluation against <i>M. abscessus</i> and the molecules that have been in development for the past five years in the early drug-discovery phase.https://www.mdpi.com/2673-9879/3/3/41<i>Mycobacterium abscessus</i>inhibitorsdrug targettherapyenzymes |
| spellingShingle | Mario Cocorullo Christian Bettoni Sara Foiadelli Giovanni Stelitano Moles of Molecules against <i>Mycobacterium abscessus</i>: A Review of Current Research Future Pharmacology <i>Mycobacterium abscessus</i> inhibitors drug target therapy enzymes |
| title | Moles of Molecules against <i>Mycobacterium abscessus</i>: A Review of Current Research |
| title_full | Moles of Molecules against <i>Mycobacterium abscessus</i>: A Review of Current Research |
| title_fullStr | Moles of Molecules against <i>Mycobacterium abscessus</i>: A Review of Current Research |
| title_full_unstemmed | Moles of Molecules against <i>Mycobacterium abscessus</i>: A Review of Current Research |
| title_short | Moles of Molecules against <i>Mycobacterium abscessus</i>: A Review of Current Research |
| title_sort | moles of molecules against i mycobacterium abscessus i a review of current research |
| topic | <i>Mycobacterium abscessus</i> inhibitors drug target therapy enzymes |
| url | https://www.mdpi.com/2673-9879/3/3/41 |
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