Health-related quality of life in patients with rheumatoid arthritis
Abstract Background Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease that primarily affects joints with some extraarticular involvement. If inappropriately treated, it usually results in persistent joint pain, irreversible deformities, and functional disability, leading to poor qua...
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| Format: | Article |
| Language: | English |
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BMC
2019-08-01
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| Series: | BMC Rheumatology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s41927-019-0080-9 |
| _version_ | 1818333831856390144 |
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| author | Wanruchada Katchamart Pongthorn Narongroeknawin Wanwisa Chanapai Phakhamon Thaweeratthakul |
| author_facet | Wanruchada Katchamart Pongthorn Narongroeknawin Wanwisa Chanapai Phakhamon Thaweeratthakul |
| author_sort | Wanruchada Katchamart |
| collection | DOAJ |
| description | Abstract Background Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease that primarily affects joints with some extraarticular involvement. If inappropriately treated, it usually results in persistent joint pain, irreversible deformities, and functional disability, leading to poor quality of life. Our objective was to evaluate health-related quality of life (HRQoL) and related factors in patients with RA. Methods Four hundred sixty-four patients from the Rheumatoid Arthritis registries of Siriraj and Phramongkutklao teaching hospitals were enrolled. Sociodemographic, clinical and laboratory data related to disease activity, and functional status were collected. HRQoL was assessed using the Thai version of EuroQol five dimensional questionnaire (EQ-5D) and EQ global health visual analogue scale (EQ VAS). Univariate and multivariate analyses were employed to identify factors related to HRQoL. Results Eighty-five percent were female with a mean age ± SD of 59.15 ± 11.43 years and a mean disease duration ± SD of 11.53 ± 8.3 years. The mean educational level ± SD was 9.42 ± 5.21 years. Almost half were unemployed or retired (47%). They had moderate disease activity (mean cumulative DAS28 ± SD, 3.5 ± 0.8) and mild functional impairment (mean HAQ ± SD, 0.70 ± 0.68). The mean EQ-5D ± SD (0–1) was 0.87 ± 0.13 and mean EQ VAS ± SD (0–10) was 7.94 ± 1.7. Based on the EQ-5D domain, 49% reported that they had no problem with mobility, 83% had no difficulties with self-care, 65% had no difficulties with usual activity, 30% had no pain or discomfort, and 61% had no depression or anxiety. The relationship between problems of each dimension in EQ-5D significantly increased according to severity of RA assessed by the Disease Activity Score (DAS) 28 and Health Assessment Questionnaire (HAQ) (p < 0.01). In multivariate analyses, high cumulative disease activity, functional disability, depression, and anxiety were negatively associated with EQ-5D (adjusted R 2 0.38, p < 0.001) and EQ VAS (adjusted R 2 0.19, p < 0.001). Conclusion Disease severity and psychological disturbance have a negative impact on quality of life in patients with RA. These factors should be considered in management of RA patients to improve the standard of care. |
| first_indexed | 2024-12-13T13:57:54Z |
| format | Article |
| id | doaj.art-3c5f01e2e86f42bf877f45acdcf37d36 |
| institution | Directory Open Access Journal |
| issn | 2520-1026 |
| language | English |
| last_indexed | 2024-12-13T13:57:54Z |
| publishDate | 2019-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Rheumatology |
| spelling | doaj.art-3c5f01e2e86f42bf877f45acdcf37d362022-12-21T23:42:50ZengBMCBMC Rheumatology2520-10262019-08-01311810.1186/s41927-019-0080-9Health-related quality of life in patients with rheumatoid arthritisWanruchada Katchamart0Pongthorn Narongroeknawin1Wanwisa Chanapai2Phakhamon Thaweeratthakul3Division of Rheumatology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol UniversityDivision of Rheumatology, Department of Medicine, Phramongkutklao Hospital and College of MedicineDivision of Clinical Trials, Research Department, Faculty of Medicine Siriraj HospitalDivision of Rheumatology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol UniversityAbstract Background Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease that primarily affects joints with some extraarticular involvement. If inappropriately treated, it usually results in persistent joint pain, irreversible deformities, and functional disability, leading to poor quality of life. Our objective was to evaluate health-related quality of life (HRQoL) and related factors in patients with RA. Methods Four hundred sixty-four patients from the Rheumatoid Arthritis registries of Siriraj and Phramongkutklao teaching hospitals were enrolled. Sociodemographic, clinical and laboratory data related to disease activity, and functional status were collected. HRQoL was assessed using the Thai version of EuroQol five dimensional questionnaire (EQ-5D) and EQ global health visual analogue scale (EQ VAS). Univariate and multivariate analyses were employed to identify factors related to HRQoL. Results Eighty-five percent were female with a mean age ± SD of 59.15 ± 11.43 years and a mean disease duration ± SD of 11.53 ± 8.3 years. The mean educational level ± SD was 9.42 ± 5.21 years. Almost half were unemployed or retired (47%). They had moderate disease activity (mean cumulative DAS28 ± SD, 3.5 ± 0.8) and mild functional impairment (mean HAQ ± SD, 0.70 ± 0.68). The mean EQ-5D ± SD (0–1) was 0.87 ± 0.13 and mean EQ VAS ± SD (0–10) was 7.94 ± 1.7. Based on the EQ-5D domain, 49% reported that they had no problem with mobility, 83% had no difficulties with self-care, 65% had no difficulties with usual activity, 30% had no pain or discomfort, and 61% had no depression or anxiety. The relationship between problems of each dimension in EQ-5D significantly increased according to severity of RA assessed by the Disease Activity Score (DAS) 28 and Health Assessment Questionnaire (HAQ) (p < 0.01). In multivariate analyses, high cumulative disease activity, functional disability, depression, and anxiety were negatively associated with EQ-5D (adjusted R 2 0.38, p < 0.001) and EQ VAS (adjusted R 2 0.19, p < 0.001). Conclusion Disease severity and psychological disturbance have a negative impact on quality of life in patients with RA. These factors should be considered in management of RA patients to improve the standard of care.http://link.springer.com/article/10.1186/s41927-019-0080-9Rheumatoid arthritisHealth-related quality of lifeEQ-5DDAS28HAQDepression |
| spellingShingle | Wanruchada Katchamart Pongthorn Narongroeknawin Wanwisa Chanapai Phakhamon Thaweeratthakul Health-related quality of life in patients with rheumatoid arthritis BMC Rheumatology Rheumatoid arthritis Health-related quality of life EQ-5D DAS28 HAQ Depression |
| title | Health-related quality of life in patients with rheumatoid arthritis |
| title_full | Health-related quality of life in patients with rheumatoid arthritis |
| title_fullStr | Health-related quality of life in patients with rheumatoid arthritis |
| title_full_unstemmed | Health-related quality of life in patients with rheumatoid arthritis |
| title_short | Health-related quality of life in patients with rheumatoid arthritis |
| title_sort | health related quality of life in patients with rheumatoid arthritis |
| topic | Rheumatoid arthritis Health-related quality of life EQ-5D DAS28 HAQ Depression |
| url | http://link.springer.com/article/10.1186/s41927-019-0080-9 |
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