Salivary microbial profiles in relation to age, periodontal, and systemic diseases.
Analysis of saliva is emerging as a promising tool to diagnose and monitor diseases which makes determination of the salivary microbial profile in different scenarios essential.To evaluate the effects of age, periodontal disease, sex, smoking, and medical conditions on the salivary microbial profile...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2018-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5851536?pdf=render |
| _version_ | 1830382908306620416 |
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| author | Ronaldo Lira-Junior Sigvard Åkerman Björn Klinge Elisabeth A Boström Anders Gustafsson |
| author_facet | Ronaldo Lira-Junior Sigvard Åkerman Björn Klinge Elisabeth A Boström Anders Gustafsson |
| author_sort | Ronaldo Lira-Junior |
| collection | DOAJ |
| description | Analysis of saliva is emerging as a promising tool to diagnose and monitor diseases which makes determination of the salivary microbial profile in different scenarios essential.To evaluate the effects of age, periodontal disease, sex, smoking, and medical conditions on the salivary microbial profile.A randomly selected sample of 441 individuals was enrolled (51% women; mean age 48.5±16.8). Participants answered a health questionnaire and underwent an oral examination. Stimulated saliva was collected and the counts of 41 bacteria were determined by checkerboard DNA-DNA hybridization.Elderly participants (> 64 years old) presented a significant increase in 24 out of 41 bacterial species compared to adults (≤ 64 years old). Eubacterium nodatum, Porphyromonas gingivalis, and Tannerella forsythia were significantly higher in participants with generalized bone loss compared to without. Males and non-smokers had higher bacteria counts in saliva. Individuals having mental disorders or muscle and joint diseases showed significantly altered microbial profiles whereas small or no differences were found for subjects with high blood pressure, heart disease, previous heart surgery, bowel disease, tumors, or diabetes.Age, periodontal status, sex, smoking, and certain medical conditions namely, mental disorders and muscle and joint diseases, might affect the microbial profile in saliva. |
| first_indexed | 2024-12-20T10:16:42Z |
| format | Article |
| id | doaj.art-3c5fea5f149d448aa698b453780e1165 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-20T10:16:42Z |
| publishDate | 2018-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-3c5fea5f149d448aa698b453780e11652022-12-21T19:44:03ZengPublic Library of Science (PLoS)PLoS ONE1932-62032018-01-01133e018937410.1371/journal.pone.0189374Salivary microbial profiles in relation to age, periodontal, and systemic diseases.Ronaldo Lira-JuniorSigvard ÅkermanBjörn KlingeElisabeth A BoströmAnders GustafssonAnalysis of saliva is emerging as a promising tool to diagnose and monitor diseases which makes determination of the salivary microbial profile in different scenarios essential.To evaluate the effects of age, periodontal disease, sex, smoking, and medical conditions on the salivary microbial profile.A randomly selected sample of 441 individuals was enrolled (51% women; mean age 48.5±16.8). Participants answered a health questionnaire and underwent an oral examination. Stimulated saliva was collected and the counts of 41 bacteria were determined by checkerboard DNA-DNA hybridization.Elderly participants (> 64 years old) presented a significant increase in 24 out of 41 bacterial species compared to adults (≤ 64 years old). Eubacterium nodatum, Porphyromonas gingivalis, and Tannerella forsythia were significantly higher in participants with generalized bone loss compared to without. Males and non-smokers had higher bacteria counts in saliva. Individuals having mental disorders or muscle and joint diseases showed significantly altered microbial profiles whereas small or no differences were found for subjects with high blood pressure, heart disease, previous heart surgery, bowel disease, tumors, or diabetes.Age, periodontal status, sex, smoking, and certain medical conditions namely, mental disorders and muscle and joint diseases, might affect the microbial profile in saliva.http://europepmc.org/articles/PMC5851536?pdf=render |
| spellingShingle | Ronaldo Lira-Junior Sigvard Åkerman Björn Klinge Elisabeth A Boström Anders Gustafsson Salivary microbial profiles in relation to age, periodontal, and systemic diseases. PLoS ONE |
| title | Salivary microbial profiles in relation to age, periodontal, and systemic diseases. |
| title_full | Salivary microbial profiles in relation to age, periodontal, and systemic diseases. |
| title_fullStr | Salivary microbial profiles in relation to age, periodontal, and systemic diseases. |
| title_full_unstemmed | Salivary microbial profiles in relation to age, periodontal, and systemic diseases. |
| title_short | Salivary microbial profiles in relation to age, periodontal, and systemic diseases. |
| title_sort | salivary microbial profiles in relation to age periodontal and systemic diseases |
| url | http://europepmc.org/articles/PMC5851536?pdf=render |
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