False-Positive Malignant Diagnosis of Nodule Mimicking Lesions by Computer-Aided Thyroid Nodule Analysis in Clinical Ultrasonography Practice
This study aims to test computer-aided diagnosis (CAD) for thyroid nodules in clinical ultrasonography (US) practice with a focus towards identifying thyroid entities associated with CAD system misdiagnoses. Two-hundred patients referred to thyroid US were prospectively enrolled. An experienced radi...
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| Format: | Article |
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MDPI AG
2020-06-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/10/6/378 |
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| author | Krisztián Molnár Endre Kálmán Zsófia Hári Omar Giyab Tamás Gáspár Károly Rucz Péter Bogner Arnold Tóth |
| author_facet | Krisztián Molnár Endre Kálmán Zsófia Hári Omar Giyab Tamás Gáspár Károly Rucz Péter Bogner Arnold Tóth |
| author_sort | Krisztián Molnár |
| collection | DOAJ |
| description | This study aims to test computer-aided diagnosis (CAD) for thyroid nodules in clinical ultrasonography (US) practice with a focus towards identifying thyroid entities associated with CAD system misdiagnoses. Two-hundred patients referred to thyroid US were prospectively enrolled. An experienced radiologist evaluated the thyroid nodules and saved axial images for further offline blinded analysis using a commercially available CAD system. To represent clinical practice, not only true nodules, but mimicking lesions were also included. Fine needle aspiration biopsy (FNAB) was performed according to present guidelines. US features and thyroid entities significantly associated with CAD system misdiagnosis were identified along with the diagnostic accuracy of the radiologist and the CAD system. Diagnostic specificity regarding the radiologist was significantly (<i>p</i> < 0.05) higher than when compared with the CAD system (88.1% vs. 40.5%) while no significant difference was found in the sensitivity (88.6% vs. 80%). Focal inhomogeneities and true nodules in thyroiditis, nodules with coarse calcification and inspissated colloid cystic nodules were significantly (<i>p</i> < 0.05) associated with CAD system misdiagnosis as false-positives. The commercially available CAD system is promising when used to exclude thyroid malignancies, however, it currently may not be able to reduce unnecessary FNABs, mainly due to the false-positive diagnoses of nodule mimicking lesions. |
| first_indexed | 2024-03-10T19:19:41Z |
| format | Article |
| id | doaj.art-3c652e5e6c374305a2972a806cd547a6 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-10T19:19:41Z |
| publishDate | 2020-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-3c652e5e6c374305a2972a806cd547a62023-11-20T03:03:59ZengMDPI AGDiagnostics2075-44182020-06-0110637810.3390/diagnostics10060378False-Positive Malignant Diagnosis of Nodule Mimicking Lesions by Computer-Aided Thyroid Nodule Analysis in Clinical Ultrasonography PracticeKrisztián Molnár0Endre Kálmán1Zsófia Hári2Omar Giyab3Tamás Gáspár4Károly Rucz5Péter Bogner6Arnold Tóth7Department of Diagnostic Imaging, University of Pécs Medical School, Ifjúság út 13, 7624 Pécs, HungaryDepartment of Pathology, University of Pécs Medical School, Szigeti Út 12, 7643 Pécs, HungaryDepartment of Diagnostic Imaging, University of Pécs Medical School, Ifjúság út 13, 7624 Pécs, HungaryDepartment of Diagnostic Imaging, University of Pécs Medical School, Ifjúság út 13, 7624 Pécs, HungaryDepartment of Diagnostic Imaging, University of Pécs Medical School, Ifjúság út 13, 7624 Pécs, Hungary1st Department of Medicine, Division of Endocrinology, University of Pécs Medical School, Ifjúság út 13, 7624 Pécs, HungaryDepartment of Diagnostic Imaging, University of Pécs Medical School, Ifjúság út 13, 7624 Pécs, HungaryDepartment of Diagnostic Imaging, University of Pécs Medical School, Ifjúság út 13, 7624 Pécs, HungaryThis study aims to test computer-aided diagnosis (CAD) for thyroid nodules in clinical ultrasonography (US) practice with a focus towards identifying thyroid entities associated with CAD system misdiagnoses. Two-hundred patients referred to thyroid US were prospectively enrolled. An experienced radiologist evaluated the thyroid nodules and saved axial images for further offline blinded analysis using a commercially available CAD system. To represent clinical practice, not only true nodules, but mimicking lesions were also included. Fine needle aspiration biopsy (FNAB) was performed according to present guidelines. US features and thyroid entities significantly associated with CAD system misdiagnosis were identified along with the diagnostic accuracy of the radiologist and the CAD system. Diagnostic specificity regarding the radiologist was significantly (<i>p</i> < 0.05) higher than when compared with the CAD system (88.1% vs. 40.5%) while no significant difference was found in the sensitivity (88.6% vs. 80%). Focal inhomogeneities and true nodules in thyroiditis, nodules with coarse calcification and inspissated colloid cystic nodules were significantly (<i>p</i> < 0.05) associated with CAD system misdiagnosis as false-positives. The commercially available CAD system is promising when used to exclude thyroid malignancies, however, it currently may not be able to reduce unnecessary FNABs, mainly due to the false-positive diagnoses of nodule mimicking lesions.https://www.mdpi.com/2075-4418/10/6/378computer-assisted diagnosisultrasonographythyroid nodulethyroid cancerdiagnostic errors |
| spellingShingle | Krisztián Molnár Endre Kálmán Zsófia Hári Omar Giyab Tamás Gáspár Károly Rucz Péter Bogner Arnold Tóth False-Positive Malignant Diagnosis of Nodule Mimicking Lesions by Computer-Aided Thyroid Nodule Analysis in Clinical Ultrasonography Practice Diagnostics computer-assisted diagnosis ultrasonography thyroid nodule thyroid cancer diagnostic errors |
| title | False-Positive Malignant Diagnosis of Nodule Mimicking Lesions by Computer-Aided Thyroid Nodule Analysis in Clinical Ultrasonography Practice |
| title_full | False-Positive Malignant Diagnosis of Nodule Mimicking Lesions by Computer-Aided Thyroid Nodule Analysis in Clinical Ultrasonography Practice |
| title_fullStr | False-Positive Malignant Diagnosis of Nodule Mimicking Lesions by Computer-Aided Thyroid Nodule Analysis in Clinical Ultrasonography Practice |
| title_full_unstemmed | False-Positive Malignant Diagnosis of Nodule Mimicking Lesions by Computer-Aided Thyroid Nodule Analysis in Clinical Ultrasonography Practice |
| title_short | False-Positive Malignant Diagnosis of Nodule Mimicking Lesions by Computer-Aided Thyroid Nodule Analysis in Clinical Ultrasonography Practice |
| title_sort | false positive malignant diagnosis of nodule mimicking lesions by computer aided thyroid nodule analysis in clinical ultrasonography practice |
| topic | computer-assisted diagnosis ultrasonography thyroid nodule thyroid cancer diagnostic errors |
| url | https://www.mdpi.com/2075-4418/10/6/378 |
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