Uric acid transporter inhibitors for gout
Gout is a common inflammatory arthritis that is caused by chronically-elevated serum uric acid (sUA) levels (hyperuricemia). In humans, sUA levels are predominantly controlled by a variety of transporters that mediate the elimination of uric acid through the kidneys and intestines, a process that is...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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International Association of Physical Chemists (IAPC)
2017-06-01
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| Series: | ADMET and DMPK |
| Subjects: | |
| Online Access: | http://pub.iapchem.org/ojs/index.php/admet/article/view/387 |
| _version_ | 1817981190945112064 |
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| author | Philip K. Tan Jeffrey N. Miner |
| author_facet | Philip K. Tan Jeffrey N. Miner |
| author_sort | Philip K. Tan |
| collection | DOAJ |
| description | Gout is a common inflammatory arthritis that is caused by chronically-elevated serum uric acid (sUA) levels (hyperuricemia). In humans, sUA levels are predominantly controlled by a variety of transporters that mediate the elimination of uric acid through the kidneys and intestines, a process that is altered in most gout patients. In this review, we highlight our current understanding of uric acid handling in healthy individuals and gout patients, therapies for gout that target uric acid transporters, and the mechanism of other therapies that alter sUA levels through interactions with uric acid transporters. |
| first_indexed | 2024-04-13T23:02:42Z |
| format | Article |
| id | doaj.art-3c67fb428ae6422286e4d7f630fdfeb3 |
| institution | Directory Open Access Journal |
| issn | 1848-7718 |
| language | English |
| last_indexed | 2024-04-13T23:02:42Z |
| publishDate | 2017-06-01 |
| publisher | International Association of Physical Chemists (IAPC) |
| record_format | Article |
| series | ADMET and DMPK |
| spelling | doaj.art-3c67fb428ae6422286e4d7f630fdfeb32022-12-22T02:25:46ZengInternational Association of Physical Chemists (IAPC)ADMET and DMPK1848-77182017-06-0152597410.5599/admet.5.2.387254Uric acid transporter inhibitors for goutPhilip K. TanJeffrey N. MinerGout is a common inflammatory arthritis that is caused by chronically-elevated serum uric acid (sUA) levels (hyperuricemia). In humans, sUA levels are predominantly controlled by a variety of transporters that mediate the elimination of uric acid through the kidneys and intestines, a process that is altered in most gout patients. In this review, we highlight our current understanding of uric acid handling in healthy individuals and gout patients, therapies for gout that target uric acid transporters, and the mechanism of other therapies that alter sUA levels through interactions with uric acid transporters.http://pub.iapchem.org/ojs/index.php/admet/article/view/387GouthyperuricemiauricaseURAT1coevolutionurate transporters for urate homeostasis |
| spellingShingle | Philip K. Tan Jeffrey N. Miner Uric acid transporter inhibitors for gout ADMET and DMPK Gout hyperuricemia uricase URAT1 coevolution urate transporters for urate homeostasis |
| title | Uric acid transporter inhibitors for gout |
| title_full | Uric acid transporter inhibitors for gout |
| title_fullStr | Uric acid transporter inhibitors for gout |
| title_full_unstemmed | Uric acid transporter inhibitors for gout |
| title_short | Uric acid transporter inhibitors for gout |
| title_sort | uric acid transporter inhibitors for gout |
| topic | Gout hyperuricemia uricase URAT1 coevolution urate transporters for urate homeostasis |
| url | http://pub.iapchem.org/ojs/index.php/admet/article/view/387 |
| work_keys_str_mv | AT philipktan uricacidtransporterinhibitorsforgout AT jeffreynminer uricacidtransporterinhibitorsforgout |