Mitotic WNT: aligning chromosomes through KIF2A
WNT signaling regulates cell cycle progression and fate determination through β-catenin dependent transcription, and its misregulation is often associated with tumorigenesis. Our recent work demonstrated that basal WNT activity is also required to ensure proper chromosome alignment during mitosis th...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2021-11-01
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| Series: | Molecular & Cellular Oncology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/23723556.2021.2011564 |
| _version_ | 1797677066632560640 |
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| author | Anja Bufe Sergio P. Acebrón |
| author_facet | Anja Bufe Sergio P. Acebrón |
| author_sort | Anja Bufe |
| collection | DOAJ |
| description | WNT signaling regulates cell cycle progression and fate determination through β-catenin dependent transcription, and its misregulation is often associated with tumorigenesis. Our recent work demonstrated that basal WNT activity is also required to ensure proper chromosome alignment during mitosis through the regulation of kinesin family member 2A (KIF2A). |
| first_indexed | 2024-03-11T22:39:39Z |
| format | Article |
| id | doaj.art-3c6814601fc84bf8bbc65a67e040fd3d |
| institution | Directory Open Access Journal |
| issn | 2372-3556 |
| language | English |
| last_indexed | 2024-03-11T22:39:39Z |
| publishDate | 2021-11-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Molecular & Cellular Oncology |
| spelling | doaj.art-3c6814601fc84bf8bbc65a67e040fd3d2023-09-22T09:19:44ZengTaylor & Francis GroupMolecular & Cellular Oncology2372-35562021-11-018610.1080/23723556.2021.20115642011564Mitotic WNT: aligning chromosomes through KIF2AAnja Bufe0Sergio P. Acebrón1Heidelberg UniversityHeidelberg UniversityWNT signaling regulates cell cycle progression and fate determination through β-catenin dependent transcription, and its misregulation is often associated with tumorigenesis. Our recent work demonstrated that basal WNT activity is also required to ensure proper chromosome alignment during mitosis through the regulation of kinesin family member 2A (KIF2A).http://dx.doi.org/10.1080/23723556.2021.2011564wnt signalingkinesin-13disheveledchromosome congressionplk1 |
| spellingShingle | Anja Bufe Sergio P. Acebrón Mitotic WNT: aligning chromosomes through KIF2A Molecular & Cellular Oncology wnt signaling kinesin-13 disheveled chromosome congression plk1 |
| title | Mitotic WNT: aligning chromosomes through KIF2A |
| title_full | Mitotic WNT: aligning chromosomes through KIF2A |
| title_fullStr | Mitotic WNT: aligning chromosomes through KIF2A |
| title_full_unstemmed | Mitotic WNT: aligning chromosomes through KIF2A |
| title_short | Mitotic WNT: aligning chromosomes through KIF2A |
| title_sort | mitotic wnt aligning chromosomes through kif2a |
| topic | wnt signaling kinesin-13 disheveled chromosome congression plk1 |
| url | http://dx.doi.org/10.1080/23723556.2021.2011564 |
| work_keys_str_mv | AT anjabufe mitoticwntaligningchromosomesthroughkif2a AT sergiopacebron mitoticwntaligningchromosomesthroughkif2a |