Nanotechnology prospects in brain therapeutics concerning gene-targeting and nose-to-brain administration
Summary: Neurological diseases are one of the most pressing issues in modern times worldwide. It thus possesses explicit attention from researchers and medical health providers to guard public health against such an expanding threat. Various treatment modalities have been developed in a remarkably s...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-08-01
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| Series: | iScience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004223013986 |
| _version_ | 1797770728304541696 |
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| author | Dong-Dong Wu Yasmine Ahmed Salah Ebenezeri Erasto Ngowi Yan-Xia Zhang Saadullah Khattak Nazeer Hussain Khan Yan Wang Tao Li Zi-Hua Guo Yan-Mei Wang Xin-Ying Ji |
| author_facet | Dong-Dong Wu Yasmine Ahmed Salah Ebenezeri Erasto Ngowi Yan-Xia Zhang Saadullah Khattak Nazeer Hussain Khan Yan Wang Tao Li Zi-Hua Guo Yan-Mei Wang Xin-Ying Ji |
| author_sort | Dong-Dong Wu |
| collection | DOAJ |
| description | Summary: Neurological diseases are one of the most pressing issues in modern times worldwide. It thus possesses explicit attention from researchers and medical health providers to guard public health against such an expanding threat. Various treatment modalities have been developed in a remarkably short time but, unfortunately, have yet to lead to the wished-for efficacy or the sought-after clinical improvement. The main hurdle in delivering therapeutics to the brain has always been the blood-brain barrier which still represents an elusive area with lots of mysteries yet to be solved. Meanwhile, nanotechnology has emerged as an optimistic platform that is potentially holding the answer to many of our questions on how to deliver drugs and treat CNS disorders using novel technologies rather than the unsatisfying conventional old methods. Nanocarriers can be engineered in a way that is capable of delivering a certain therapeutic cargo to a specific target tissue. Adding to this mind-blowing nanotechnology, the revolutionizing gene-altering biologics can have the best of both worlds, and pave the way for the long-awaited cure to many diseases, among those diseases thus far are Alzheimer’s disease (AD), brain tumors (glioma and glioblastoma), Down syndrome, stroke, and even cases with HIV. The review herein collects the studies that tested the mixture of both sciences, nanotechnology, and epigenetics, in the context of brain therapeutics using three main categories of gene-altering molecules (siRNA, miRNA, and CRISPR) with a special focus on the advancements regarding the new favorite, intranasal route of administration. |
| first_indexed | 2024-03-12T21:27:26Z |
| format | Article |
| id | doaj.art-3c68a168f78741feb0ade71012a43876 |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-03-12T21:27:26Z |
| publishDate | 2023-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-3c68a168f78741feb0ade71012a438762023-07-28T04:26:30ZengElsevieriScience2589-00422023-08-01268107321Nanotechnology prospects in brain therapeutics concerning gene-targeting and nose-to-brain administrationDong-Dong Wu0Yasmine Ahmed Salah1Ebenezeri Erasto Ngowi2Yan-Xia Zhang3Saadullah Khattak4Nazeer Hussain Khan5Yan Wang6Tao Li7Zi-Hua Guo8Yan-Mei Wang9Xin-Ying Ji10Henan International Joint Laboratory for Nuclear Protein Regulation, School of Basic Medical Sciences, Henan University, Kaifeng, Henan 475004, China; School of Stomatology, Henan University, Kaifeng, Henan 475004, ChinaHenan International Joint Laboratory for Nuclear Protein Regulation, School of Basic Medical Sciences, Henan University, Kaifeng, Henan 475004, China; Department of Pathology, Faculty of Medicine, Ain Shams University, Cairo 11517, EgyptHenan International Joint Laboratory for Nuclear Protein Regulation, School of Basic Medical Sciences, Henan University, Kaifeng, Henan 475004, China; Department of Biological Sciences, Dar es Salaam University College of Education, Dar es Salaam 2329, TanzaniaHenan International Joint Laboratory for Nuclear Protein Regulation, School of Basic Medical Sciences, Henan University, Kaifeng, Henan 475004, ChinaHenan International Joint Laboratory for Nuclear Protein Regulation, School of Basic Medical Sciences, Henan University, Kaifeng, Henan 475004, China; School of Life Sciences, Henan University, Kaifeng, Henan 475004, ChinaHenan International Joint Laboratory for Nuclear Protein Regulation, School of Basic Medical Sciences, Henan University, Kaifeng, Henan 475004, China; School of Life Sciences, Henan University, Kaifeng, Henan 475004, ChinaHenan International Joint Laboratory for Nuclear Protein Regulation, School of Basic Medical Sciences, Henan University, Kaifeng, Henan 475004, ChinaHenan International Joint Laboratory for Nuclear Protein Regulation, School of Basic Medical Sciences, Henan University, Kaifeng, Henan 475004, ChinaHenan International Joint Laboratory for Nuclear Protein Regulation, School of Basic Medical Sciences, Henan University, Kaifeng, Henan 475004, China; Department of Neurology, Kaifeng Hospital of Traditional Chinese Medicine, Henan University, Kaifeng, Henan 475000, ChinaHenan International Joint Laboratory for Nuclear Protein Regulation, School of Basic Medical Sciences, Henan University, Kaifeng, Henan 475004, China; School of Nursing and Health, Henan University, Kaifeng, Henan 475004, China; Corresponding authorHenan International Joint Laboratory for Nuclear Protein Regulation, School of Basic Medical Sciences, Henan University, Kaifeng, Henan 475004, China; Kaifeng Key Laboratory of Infection and Biological Safety, School of Basic Medical Sciences, Henan University, Kaifeng, Henan 475004, China; Corresponding authorSummary: Neurological diseases are one of the most pressing issues in modern times worldwide. It thus possesses explicit attention from researchers and medical health providers to guard public health against such an expanding threat. Various treatment modalities have been developed in a remarkably short time but, unfortunately, have yet to lead to the wished-for efficacy or the sought-after clinical improvement. The main hurdle in delivering therapeutics to the brain has always been the blood-brain barrier which still represents an elusive area with lots of mysteries yet to be solved. Meanwhile, nanotechnology has emerged as an optimistic platform that is potentially holding the answer to many of our questions on how to deliver drugs and treat CNS disorders using novel technologies rather than the unsatisfying conventional old methods. Nanocarriers can be engineered in a way that is capable of delivering a certain therapeutic cargo to a specific target tissue. Adding to this mind-blowing nanotechnology, the revolutionizing gene-altering biologics can have the best of both worlds, and pave the way for the long-awaited cure to many diseases, among those diseases thus far are Alzheimer’s disease (AD), brain tumors (glioma and glioblastoma), Down syndrome, stroke, and even cases with HIV. The review herein collects the studies that tested the mixture of both sciences, nanotechnology, and epigenetics, in the context of brain therapeutics using three main categories of gene-altering molecules (siRNA, miRNA, and CRISPR) with a special focus on the advancements regarding the new favorite, intranasal route of administration.http://www.sciencedirect.com/science/article/pii/S2589004223013986PharmacologyGenetics |
| spellingShingle | Dong-Dong Wu Yasmine Ahmed Salah Ebenezeri Erasto Ngowi Yan-Xia Zhang Saadullah Khattak Nazeer Hussain Khan Yan Wang Tao Li Zi-Hua Guo Yan-Mei Wang Xin-Ying Ji Nanotechnology prospects in brain therapeutics concerning gene-targeting and nose-to-brain administration iScience Pharmacology Genetics |
| title | Nanotechnology prospects in brain therapeutics concerning gene-targeting and nose-to-brain administration |
| title_full | Nanotechnology prospects in brain therapeutics concerning gene-targeting and nose-to-brain administration |
| title_fullStr | Nanotechnology prospects in brain therapeutics concerning gene-targeting and nose-to-brain administration |
| title_full_unstemmed | Nanotechnology prospects in brain therapeutics concerning gene-targeting and nose-to-brain administration |
| title_short | Nanotechnology prospects in brain therapeutics concerning gene-targeting and nose-to-brain administration |
| title_sort | nanotechnology prospects in brain therapeutics concerning gene targeting and nose to brain administration |
| topic | Pharmacology Genetics |
| url | http://www.sciencedirect.com/science/article/pii/S2589004223013986 |
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