Clinical Manifestations and Molecular Diagnosis of Scrub Typhus and Murine Typhus, Vietnam, 2015–2017
Rickettsioses are endemic to Vietnam; however, only a limited number of clinical studies have been performed on these vectorborne bacteria. We conducted a prospective hospital-based study at 2 national referral hospitals in Hanoi to describe the clinical characteristics of scrub typhus and murine ty...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Centers for Disease Control and Prevention
2019-04-01
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| Series: | Emerging Infectious Diseases |
| Subjects: | |
| Online Access: | https://wwwnc.cdc.gov/eid/article/25/4/18-0691_article |
| _version_ | 1818041213913137152 |
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| author | Nguyen Vu Trung Le Thi Hoi Vu Minh Dien Dang Thi Huong Tran Mai Hoa Vu Ngoc Lien Phan Van Luan Sonia Odette Lewycka Marc Choisy Juliet E. Bryant Behzad Nadjm H. Rogier van Doorn Allen L. Richards Nguyen Van Kinh |
| author_facet | Nguyen Vu Trung Le Thi Hoi Vu Minh Dien Dang Thi Huong Tran Mai Hoa Vu Ngoc Lien Phan Van Luan Sonia Odette Lewycka Marc Choisy Juliet E. Bryant Behzad Nadjm H. Rogier van Doorn Allen L. Richards Nguyen Van Kinh |
| author_sort | Nguyen Vu Trung |
| collection | DOAJ |
| description | Rickettsioses are endemic to Vietnam; however, only a limited number of clinical studies have been performed on these vectorborne bacteria. We conducted a prospective hospital-based study at 2 national referral hospitals in Hanoi to describe the clinical characteristics of scrub typhus and murine typhus in northern Vietnam and to assess the diagnostic applicability of quantitative real-time PCR assays to diagnose rickettsial diseases. We enrolled 302 patients with acute undifferentiated fever and clinically suspected rickettsiosis during March 2015–March 2017. We used a standardized case report form to collect clinical information and laboratory results at the time of admission and during treatment. We confirmed scrub typhus in 103 (34.1%) patients and murine typhus in 12 (3.3%) patients. These results highlight the need for increased emphasis on training for healthcare providers for earlier recognition, prevention, and treatment of rickettsial diseases in Vietnam. |
| first_indexed | 2024-12-10T08:26:51Z |
| format | Article |
| id | doaj.art-3c69aa9de6c344c99b6dc37dad6a39e6 |
| institution | Directory Open Access Journal |
| issn | 1080-6040 1080-6059 |
| language | English |
| last_indexed | 2024-12-10T08:26:51Z |
| publishDate | 2019-04-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj.art-3c69aa9de6c344c99b6dc37dad6a39e62022-12-22T01:56:13ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592019-04-0125463364110.3201/eid2504.180691Clinical Manifestations and Molecular Diagnosis of Scrub Typhus and Murine Typhus, Vietnam, 2015–2017Nguyen Vu TrungLe Thi HoiVu Minh DienDang Thi HuongTran Mai HoaVu Ngoc LienPhan Van LuanSonia Odette LewyckaMarc ChoisyJuliet E. BryantBehzad NadjmH. Rogier van DoornAllen L. RichardsNguyen Van KinhRickettsioses are endemic to Vietnam; however, only a limited number of clinical studies have been performed on these vectorborne bacteria. We conducted a prospective hospital-based study at 2 national referral hospitals in Hanoi to describe the clinical characteristics of scrub typhus and murine typhus in northern Vietnam and to assess the diagnostic applicability of quantitative real-time PCR assays to diagnose rickettsial diseases. We enrolled 302 patients with acute undifferentiated fever and clinically suspected rickettsiosis during March 2015–March 2017. We used a standardized case report form to collect clinical information and laboratory results at the time of admission and during treatment. We confirmed scrub typhus in 103 (34.1%) patients and murine typhus in 12 (3.3%) patients. These results highlight the need for increased emphasis on training for healthcare providers for earlier recognition, prevention, and treatment of rickettsial diseases in Vietnam.https://wwwnc.cdc.gov/eid/article/25/4/18-0691_articleScrub typhusmurine typhusrickettsial diseasesqPCRVietnambacteria |
| spellingShingle | Nguyen Vu Trung Le Thi Hoi Vu Minh Dien Dang Thi Huong Tran Mai Hoa Vu Ngoc Lien Phan Van Luan Sonia Odette Lewycka Marc Choisy Juliet E. Bryant Behzad Nadjm H. Rogier van Doorn Allen L. Richards Nguyen Van Kinh Clinical Manifestations and Molecular Diagnosis of Scrub Typhus and Murine Typhus, Vietnam, 2015–2017 Emerging Infectious Diseases Scrub typhus murine typhus rickettsial diseases qPCR Vietnam bacteria |
| title | Clinical Manifestations and Molecular Diagnosis of Scrub Typhus and Murine Typhus, Vietnam, 2015–2017 |
| title_full | Clinical Manifestations and Molecular Diagnosis of Scrub Typhus and Murine Typhus, Vietnam, 2015–2017 |
| title_fullStr | Clinical Manifestations and Molecular Diagnosis of Scrub Typhus and Murine Typhus, Vietnam, 2015–2017 |
| title_full_unstemmed | Clinical Manifestations and Molecular Diagnosis of Scrub Typhus and Murine Typhus, Vietnam, 2015–2017 |
| title_short | Clinical Manifestations and Molecular Diagnosis of Scrub Typhus and Murine Typhus, Vietnam, 2015–2017 |
| title_sort | clinical manifestations and molecular diagnosis of scrub typhus and murine typhus vietnam 2015 2017 |
| topic | Scrub typhus murine typhus rickettsial diseases qPCR Vietnam bacteria |
| url | https://wwwnc.cdc.gov/eid/article/25/4/18-0691_article |
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