Ability of polymicrobial probiotic and mono-strain probiotic to reduce functional abdominal pain in children: a randomized clinical trial
Background Chronic abdominal pain is a common problem in childhood. Purpose Due to the prevalence of functional abdominal pain (FAP) and the importance of probiotics, this study aimed to compare the ability of 2 probiotics to reduce and improve FAP in children. Methods This open-label randomized cli...
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| Format: | Article |
| Language: | English |
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The Korean Pediatric Society
2022-12-01
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| Series: | Clinical and Experimental Pediatrics |
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| Online Access: | http://www.e-cep.org/upload/pdf/cep-2022-00339.pdf |
| _version_ | 1797987566090190848 |
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| author | Seyed Sajad Jafari Seyed Mojtaba Hashemi Bahman Sadeghi Amir Almasi-Hashiani |
| author_facet | Seyed Sajad Jafari Seyed Mojtaba Hashemi Bahman Sadeghi Amir Almasi-Hashiani |
| author_sort | Seyed Sajad Jafari |
| collection | DOAJ |
| description | Background Chronic abdominal pain is a common problem in childhood. Purpose Due to the prevalence of functional abdominal pain (FAP) and the importance of probiotics, this study aimed to compare the ability of 2 probiotics to reduce and improve FAP in children. Methods This open-label randomized clinical trial included 116 children aged 5–15 years with FAPP who met the ROME-4 criteria and were referred to the gastrointestinal clinic of Amir-Kabir Hospital in Arak in 2020–2021. The children were randomly allocated to receive polymicrobial probiotic (PMP group) or mono-strain probiotic (MSP group) once daily for 4 weeks. The standard Wong-Baker Faces scale was used to assess symptom severity. Results Of the 116 subjects, 62 (53.5%) were boys; the mean participant age was 7.39 years (standard deviation, 3.4 years). A significant intergroup difference (P=0.003) was observed in pain severity; 10.34% of children in the PMP group had no pain, while all patients in the MSP group reported low-degree pain. There was no intergroup difference in mean pain score (P=0.466), but it decreased over time in both groups (P= 0.001). Conclusion Although significantly more children were painless in the PMP versus MSP group, no significant intergroup difference in pain score was noted and symptom severity decreased in both groups. A future study with a placebo group is recommended to validate our findings. |
| first_indexed | 2024-04-11T07:50:15Z |
| format | Article |
| id | doaj.art-3c6bdd7972a244889f4a661558e701c7 |
| institution | Directory Open Access Journal |
| issn | 2713-4148 |
| language | English |
| last_indexed | 2024-04-11T07:50:15Z |
| publishDate | 2022-12-01 |
| publisher | The Korean Pediatric Society |
| record_format | Article |
| series | Clinical and Experimental Pediatrics |
| spelling | doaj.art-3c6bdd7972a244889f4a661558e701c72022-12-22T04:36:06ZengThe Korean Pediatric SocietyClinical and Experimental Pediatrics2713-41482022-12-01651258959410.3345/cep.2022.0033920125555564Ability of polymicrobial probiotic and mono-strain probiotic to reduce functional abdominal pain in children: a randomized clinical trialSeyed Sajad Jafari0Seyed Mojtaba Hashemi1Bahman Sadeghi2Amir Almasi-Hashiani3 Student Research Committee, Arak University of Medical Sciences, Arak, Iran Department of Pediatric Gastroenterology, Arak University of Medical Sciences, Arak, Iran Department of Health and Community Medicine, School of Medicine, Arak University of Medical Sciences, Arak, Iran Department of Epidemiology, Arak University of Medical Sciences, Arak, IranBackground Chronic abdominal pain is a common problem in childhood. Purpose Due to the prevalence of functional abdominal pain (FAP) and the importance of probiotics, this study aimed to compare the ability of 2 probiotics to reduce and improve FAP in children. Methods This open-label randomized clinical trial included 116 children aged 5–15 years with FAPP who met the ROME-4 criteria and were referred to the gastrointestinal clinic of Amir-Kabir Hospital in Arak in 2020–2021. The children were randomly allocated to receive polymicrobial probiotic (PMP group) or mono-strain probiotic (MSP group) once daily for 4 weeks. The standard Wong-Baker Faces scale was used to assess symptom severity. Results Of the 116 subjects, 62 (53.5%) were boys; the mean participant age was 7.39 years (standard deviation, 3.4 years). A significant intergroup difference (P=0.003) was observed in pain severity; 10.34% of children in the PMP group had no pain, while all patients in the MSP group reported low-degree pain. There was no intergroup difference in mean pain score (P=0.466), but it decreased over time in both groups (P= 0.001). Conclusion Although significantly more children were painless in the PMP versus MSP group, no significant intergroup difference in pain score was noted and symptom severity decreased in both groups. A future study with a placebo group is recommended to validate our findings.http://www.e-cep.org/upload/pdf/cep-2022-00339.pdfprobioticpediatricfunctional abdominal painchildpain |
| spellingShingle | Seyed Sajad Jafari Seyed Mojtaba Hashemi Bahman Sadeghi Amir Almasi-Hashiani Ability of polymicrobial probiotic and mono-strain probiotic to reduce functional abdominal pain in children: a randomized clinical trial Clinical and Experimental Pediatrics probiotic pediatric functional abdominal pain child pain |
| title | Ability of polymicrobial probiotic and mono-strain probiotic to reduce functional abdominal pain in children: a randomized clinical trial |
| title_full | Ability of polymicrobial probiotic and mono-strain probiotic to reduce functional abdominal pain in children: a randomized clinical trial |
| title_fullStr | Ability of polymicrobial probiotic and mono-strain probiotic to reduce functional abdominal pain in children: a randomized clinical trial |
| title_full_unstemmed | Ability of polymicrobial probiotic and mono-strain probiotic to reduce functional abdominal pain in children: a randomized clinical trial |
| title_short | Ability of polymicrobial probiotic and mono-strain probiotic to reduce functional abdominal pain in children: a randomized clinical trial |
| title_sort | ability of polymicrobial probiotic and mono strain probiotic to reduce functional abdominal pain in children a randomized clinical trial |
| topic | probiotic pediatric functional abdominal pain child pain |
| url | http://www.e-cep.org/upload/pdf/cep-2022-00339.pdf |
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