Comprehensive evaluation of immune dysregulation in secondary hemophagocytic lymphohistiocytosis
ABSTRACTHost immune dysfunction plays a crucial role in the onset, progression, and outcome of hemophagocytic lymphohistiocytosis (HLH). This study aimed to comprehensively evaluate the peripheral immune profiles in patients with newly diagnosed secondary hemophagocytic lymphohistiocytosis (sHLH), a...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Virulence |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/21505594.2024.2342276 |
| _version_ | 1827278712674975744 |
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| author | Yun Wang Xu Yuan Ting Wang Wei Wei Shiji Wu Hongyan Hou |
| author_facet | Yun Wang Xu Yuan Ting Wang Wei Wei Shiji Wu Hongyan Hou |
| author_sort | Yun Wang |
| collection | DOAJ |
| description | ABSTRACTHost immune dysfunction plays a crucial role in the onset, progression, and outcome of hemophagocytic lymphohistiocytosis (HLH). This study aimed to comprehensively evaluate the peripheral immune profiles in patients with newly diagnosed secondary hemophagocytic lymphohistiocytosis (sHLH), and explore their predictive value for patient prognosis. A total of 77 patients with sHLH were enrolled in this study, with 31 of them experiencing mortality. Flow cytometry was used to assess the percentages, absolute numbers, and phenotypes of lymphocyte subsets. Simultaneously, cytokine levels and routine laboratory indicators were also collected. In sHLH patients, lymphocyte subset absolute numbers were significantly impaired, accompanied by T cell hyperactivation, B cell hyperactivation, and increased plasmablast proliferation. Prognostic analysis revealed that lower CD8+ T cell percentages, elevated APTT, IL-6, IL-10 levels, and increased CD4+CD28null T cell proportions were associated with poor patient outcomes. The study demonstrates dysregulation in the counts and phenotypes of lymphocyte subsets in sHLH patients. Several key factors, including IL-6, IL-10, APTT, and various T cell percentages, have potential as prognostic markers and therapeutic targets in sHLH. |
| first_indexed | 2024-04-24T08:05:51Z |
| format | Article |
| id | doaj.art-3c6ee73c0fa34439a97408d826cb06ce |
| institution | Directory Open Access Journal |
| issn | 2150-5594 2150-5608 |
| language | English |
| last_indexed | 2024-04-24T08:05:51Z |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Virulence |
| spelling | doaj.art-3c6ee73c0fa34439a97408d826cb06ce2024-04-17T09:53:38ZengTaylor & Francis GroupVirulence2150-55942150-56082024-12-0115110.1080/21505594.2024.2342276Comprehensive evaluation of immune dysregulation in secondary hemophagocytic lymphohistiocytosisYun Wang0Xu Yuan1Ting Wang2Wei Wei3Shiji Wu4Hongyan Hou5Department of Laboratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Laboratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Laboratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Laboratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Laboratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Laboratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaABSTRACTHost immune dysfunction plays a crucial role in the onset, progression, and outcome of hemophagocytic lymphohistiocytosis (HLH). This study aimed to comprehensively evaluate the peripheral immune profiles in patients with newly diagnosed secondary hemophagocytic lymphohistiocytosis (sHLH), and explore their predictive value for patient prognosis. A total of 77 patients with sHLH were enrolled in this study, with 31 of them experiencing mortality. Flow cytometry was used to assess the percentages, absolute numbers, and phenotypes of lymphocyte subsets. Simultaneously, cytokine levels and routine laboratory indicators were also collected. In sHLH patients, lymphocyte subset absolute numbers were significantly impaired, accompanied by T cell hyperactivation, B cell hyperactivation, and increased plasmablast proliferation. Prognostic analysis revealed that lower CD8+ T cell percentages, elevated APTT, IL-6, IL-10 levels, and increased CD4+CD28null T cell proportions were associated with poor patient outcomes. The study demonstrates dysregulation in the counts and phenotypes of lymphocyte subsets in sHLH patients. Several key factors, including IL-6, IL-10, APTT, and various T cell percentages, have potential as prognostic markers and therapeutic targets in sHLH.https://www.tandfonline.com/doi/10.1080/21505594.2024.2342276Secondary hemophagocytic lymphohistiocytosis (sHLH)laboratory parametersimmunological indicatorsprognosis |
| spellingShingle | Yun Wang Xu Yuan Ting Wang Wei Wei Shiji Wu Hongyan Hou Comprehensive evaluation of immune dysregulation in secondary hemophagocytic lymphohistiocytosis Virulence Secondary hemophagocytic lymphohistiocytosis (sHLH) laboratory parameters immunological indicators prognosis |
| title | Comprehensive evaluation of immune dysregulation in secondary hemophagocytic lymphohistiocytosis |
| title_full | Comprehensive evaluation of immune dysregulation in secondary hemophagocytic lymphohistiocytosis |
| title_fullStr | Comprehensive evaluation of immune dysregulation in secondary hemophagocytic lymphohistiocytosis |
| title_full_unstemmed | Comprehensive evaluation of immune dysregulation in secondary hemophagocytic lymphohistiocytosis |
| title_short | Comprehensive evaluation of immune dysregulation in secondary hemophagocytic lymphohistiocytosis |
| title_sort | comprehensive evaluation of immune dysregulation in secondary hemophagocytic lymphohistiocytosis |
| topic | Secondary hemophagocytic lymphohistiocytosis (sHLH) laboratory parameters immunological indicators prognosis |
| url | https://www.tandfonline.com/doi/10.1080/21505594.2024.2342276 |
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