Isoproterenol Increases Left Atrial Fibrosis and Susceptibility to Atrial Fibrillation by Inducing Atrial Ischemic Infarction in Rats

Isoproterenol Increases Left Atrial Fibrosis and Susceptibility to Atrial Fibrillation by Inducing Atrial Ischemic Infarction in Rats

Left atrial (LA) fibrosis is a major arrhythmogenic substrate for atrial fibrillation (AF). The purpose of this study was to assess whether isoproterenol (ISO) induces LA fibrosis and increases susceptibility to AF, exploring the underlying mechanisms. Male Sprague-Dawley rats were subcutaneously in...

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Bibliographic Details
Main Authors: Shiyu Ma, Jin Ma, Qingqiang Tu, Chaoyang Zheng, Qiuxiong Chen, Weihui Lv
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Pharmacology
Subjects:
atrial fibrillation
fibrosis
myocardial ischemia
isoproterenol
atrium
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00493/full

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