Elevated Glucagon in a Patient with Necrolytic Acral Erythema: A Case Report and Review of the Literature
Necrolytic acral erythema (NAE) is a relatively newly described dermatologic disease that is often associated with hepatitis C virus (HCV). Oral zinc therapy is a successful treatment; however, therapy is often delayed due to misdiagnosis. There are limited reports of NAE in the literature. This pa...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
European Medical Journal
2021-08-01
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| Series: | European Medical Journal Hepatology |
| Online Access: | https://www.emjreviews.com/hepatology/article/editors-pick-elevated-glucagon-in-a-patientwith-necrolytic-acral-erythema-a-case-report-and-review-of-the-literature-j070121/ |
| _version_ | 1797356526365573120 |
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| author | Jenna E Koblinski Blake W Traube Margaret Kessler Brenda Shinar |
| author_facet | Jenna E Koblinski Blake W Traube Margaret Kessler Brenda Shinar |
| author_sort | Jenna E Koblinski |
| collection | DOAJ |
| description |
Necrolytic acral erythema (NAE) is a relatively newly described dermatologic disease that is often associated with hepatitis C virus (HCV). Oral zinc therapy is a successful treatment; however, therapy is often delayed due to misdiagnosis. There are limited reports of NAE in the literature. This paper presents a case of NAE in a 68-year-old male with untreated HCV, whose NAE was diagnosed and treated as recurrent cellulitis for 12 years. He had low serum zinc and elevated serum glucagon levels. Elevated glucagon is not often reported in NAE, but the patient’s CT abdomen was negative, ruling out glucagonoma and necrolytic migratory erythema. He improved with oral zinc replacement and was referred to the hepatology department for HCV treatment. This paper additionally presents a review of the literature for NAE cases. |
| first_indexed | 2024-03-08T14:28:55Z |
| format | Article |
| id | doaj.art-3c7206abb1e9435cbe7c995ca16381cd |
| institution | Directory Open Access Journal |
| issn | 2053-4221 |
| language | English |
| last_indexed | 2024-03-08T14:28:55Z |
| publishDate | 2021-08-01 |
| publisher | European Medical Journal |
| record_format | Article |
| series | European Medical Journal Hepatology |
| spelling | doaj.art-3c7206abb1e9435cbe7c995ca16381cd2024-01-12T15:39:57ZengEuropean Medical JournalEuropean Medical Journal Hepatology2053-42212021-08-01475610.33590/emjhepatol/21-00031Elevated Glucagon in a Patient with Necrolytic Acral Erythema: A Case Report and Review of the LiteratureJenna E Koblinski0Blake W Traube1Margaret Kessler2Brenda Shinar3The University of Arizona College of Medicine – Phoenix, Arizona, USAThe University of Arizona College of Medicine – Phoenix, Arizona, USABanner University Medical Center – Phoenix, Arizona, USABanner University Medical Center – Phoenix, Arizona, USA;The University of Arizona College of Medicine – Phoenix, Arizona, USA Necrolytic acral erythema (NAE) is a relatively newly described dermatologic disease that is often associated with hepatitis C virus (HCV). Oral zinc therapy is a successful treatment; however, therapy is often delayed due to misdiagnosis. There are limited reports of NAE in the literature. This paper presents a case of NAE in a 68-year-old male with untreated HCV, whose NAE was diagnosed and treated as recurrent cellulitis for 12 years. He had low serum zinc and elevated serum glucagon levels. Elevated glucagon is not often reported in NAE, but the patient’s CT abdomen was negative, ruling out glucagonoma and necrolytic migratory erythema. He improved with oral zinc replacement and was referred to the hepatology department for HCV treatment. This paper additionally presents a review of the literature for NAE cases.https://www.emjreviews.com/hepatology/article/editors-pick-elevated-glucagon-in-a-patientwith-necrolytic-acral-erythema-a-case-report-and-review-of-the-literature-j070121/ |
| spellingShingle | Jenna E Koblinski Blake W Traube Margaret Kessler Brenda Shinar Elevated Glucagon in a Patient with Necrolytic Acral Erythema: A Case Report and Review of the Literature European Medical Journal Hepatology |
| title | Elevated Glucagon in a Patient with Necrolytic Acral Erythema: A Case Report and Review of the Literature |
| title_full | Elevated Glucagon in a Patient with Necrolytic Acral Erythema: A Case Report and Review of the Literature |
| title_fullStr | Elevated Glucagon in a Patient with Necrolytic Acral Erythema: A Case Report and Review of the Literature |
| title_full_unstemmed | Elevated Glucagon in a Patient with Necrolytic Acral Erythema: A Case Report and Review of the Literature |
| title_short | Elevated Glucagon in a Patient with Necrolytic Acral Erythema: A Case Report and Review of the Literature |
| title_sort | elevated glucagon in a patient with necrolytic acral erythema a case report and review of the literature |
| url | https://www.emjreviews.com/hepatology/article/editors-pick-elevated-glucagon-in-a-patientwith-necrolytic-acral-erythema-a-case-report-and-review-of-the-literature-j070121/ |
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