The interface is a tunable dimension in electricity‐driven organic synthesis
Abstract Predictive control over the selectivity outcome of an organic synthetic method is an essential hallmark of reaction success. Electricity‐driven synthesis offers a reemerging approach to facilitate the design of reaction sequences toward increased molecular complexity. In addition to the des...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley-VCH
2021-10-01
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| Series: | Natural Sciences |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/ntls.20210036 |
| _version_ | 1819176771796336640 |
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| author | Anna Wuttig Francisco Dean Toste |
| author_facet | Anna Wuttig Francisco Dean Toste |
| author_sort | Anna Wuttig |
| collection | DOAJ |
| description | Abstract Predictive control over the selectivity outcome of an organic synthetic method is an essential hallmark of reaction success. Electricity‐driven synthesis offers a reemerging approach to facilitate the design of reaction sequences toward increased molecular complexity. In addition to the desirable sustainability features of electroorganic processes, the inherent interfacial nature of electrochemical systems present unique opportunities to tune reaction selectivity. To illustrate this feature, we outline examples of mechanism‐guided interfacial control over CO2 electroreduction selectivity; a well‐studied and instructive electrochemical process with multiple reduction products that are thermodynamically accessible. These studies reveal how controlled proton delivery to the electrode surface and substrate electrosorption with the electrode dictate reaction selectivity. We describe and compare simple, yet salient, examples from the electroorganic literature, where we postulate that similar effects predominate the observed reactivity. This perspective highlights how the interface serves as a tunable dimension in electrochemical processes and delineates unique tools to study, manipulate, and achieve reaction selectivity in electricity‐driven organic synthesis. KEY POINTS Electricity‐driven synthesis enables chemical and industrial communities to contribute to sustainability goals. Electricity‐driven processes occur at phase boundaries, thus unveiling their molecular‐level roadmaps involves the synergistic study of materials, interfacial, and molecular science. Bridging concepts that transcend the topical nature of two electricity‐driven processes—CO2 reduction and electroorganic synthesis—reveals tools to manipulate reaction selectivity. |
| first_indexed | 2024-12-22T21:16:04Z |
| format | Article |
| id | doaj.art-3c7223f72a1444a2ba2b9ba237972ef9 |
| institution | Directory Open Access Journal |
| issn | 2698-6248 |
| language | English |
| last_indexed | 2024-12-22T21:16:04Z |
| publishDate | 2021-10-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Natural Sciences |
| spelling | doaj.art-3c7223f72a1444a2ba2b9ba237972ef92022-12-21T18:12:21ZengWiley-VCHNatural Sciences2698-62482021-10-0112n/an/a10.1002/ntls.20210036The interface is a tunable dimension in electricity‐driven organic synthesisAnna Wuttig0Francisco Dean Toste1Department of Chemistry University of Chicago Chicago Illinois USADepartment of Chemistry University of California Berkeley California USAAbstract Predictive control over the selectivity outcome of an organic synthetic method is an essential hallmark of reaction success. Electricity‐driven synthesis offers a reemerging approach to facilitate the design of reaction sequences toward increased molecular complexity. In addition to the desirable sustainability features of electroorganic processes, the inherent interfacial nature of electrochemical systems present unique opportunities to tune reaction selectivity. To illustrate this feature, we outline examples of mechanism‐guided interfacial control over CO2 electroreduction selectivity; a well‐studied and instructive electrochemical process with multiple reduction products that are thermodynamically accessible. These studies reveal how controlled proton delivery to the electrode surface and substrate electrosorption with the electrode dictate reaction selectivity. We describe and compare simple, yet salient, examples from the electroorganic literature, where we postulate that similar effects predominate the observed reactivity. This perspective highlights how the interface serves as a tunable dimension in electrochemical processes and delineates unique tools to study, manipulate, and achieve reaction selectivity in electricity‐driven organic synthesis. KEY POINTS Electricity‐driven synthesis enables chemical and industrial communities to contribute to sustainability goals. Electricity‐driven processes occur at phase boundaries, thus unveiling their molecular‐level roadmaps involves the synergistic study of materials, interfacial, and molecular science. Bridging concepts that transcend the topical nature of two electricity‐driven processes—CO2 reduction and electroorganic synthesis—reveals tools to manipulate reaction selectivity.https://doi.org/10.1002/ntls.20210036carbon dioxide reductionconcentration gradientselectrosorptionelectrosynthesisinterfacial scienceorganic electrochemistry |
| spellingShingle | Anna Wuttig Francisco Dean Toste The interface is a tunable dimension in electricity‐driven organic synthesis Natural Sciences carbon dioxide reduction concentration gradients electrosorption electrosynthesis interfacial science organic electrochemistry |
| title | The interface is a tunable dimension in electricity‐driven organic synthesis |
| title_full | The interface is a tunable dimension in electricity‐driven organic synthesis |
| title_fullStr | The interface is a tunable dimension in electricity‐driven organic synthesis |
| title_full_unstemmed | The interface is a tunable dimension in electricity‐driven organic synthesis |
| title_short | The interface is a tunable dimension in electricity‐driven organic synthesis |
| title_sort | interface is a tunable dimension in electricity driven organic synthesis |
| topic | carbon dioxide reduction concentration gradients electrosorption electrosynthesis interfacial science organic electrochemistry |
| url | https://doi.org/10.1002/ntls.20210036 |
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