Common and Specific Functional Activity Features in Schizophrenia, Major Depressive Disorder, and Bipolar Disorder
Objectives: Schizophrenia (SZ), major depressive disorder (MDD), and bipolar disorder (BD) are serious mental disorders with distinct diagnostic criteria. They share common clinical and biological features. However, there are still only few studies on the common and specific brain imaging changes as...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-02-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fpsyt.2019.00052/full |
| _version_ | 1819268530394103808 |
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| author | Yongfeng Yang Yongfeng Yang Yongfeng Yang Shu Liu Shu Liu Xiaoyan Jiang Hongyan Yu Shuang Ding Shuang Ding Yanli Lu Yanli Lu Wenqiang Li Wenqiang Li Hongxing Zhang Hongxing Zhang Bing Liu Bing Liu Bing Liu Yue Cui Yue Cui Yue Cui Lingzhong Fan Lingzhong Fan Lingzhong Fan Tianzi Jiang Tianzi Jiang Tianzi Jiang Tianzi Jiang Tianzi Jiang Luxian Lv Luxian Lv |
| author_facet | Yongfeng Yang Yongfeng Yang Yongfeng Yang Shu Liu Shu Liu Xiaoyan Jiang Hongyan Yu Shuang Ding Shuang Ding Yanli Lu Yanli Lu Wenqiang Li Wenqiang Li Hongxing Zhang Hongxing Zhang Bing Liu Bing Liu Bing Liu Yue Cui Yue Cui Yue Cui Lingzhong Fan Lingzhong Fan Lingzhong Fan Tianzi Jiang Tianzi Jiang Tianzi Jiang Tianzi Jiang Tianzi Jiang Luxian Lv Luxian Lv |
| author_sort | Yongfeng Yang |
| collection | DOAJ |
| description | Objectives: Schizophrenia (SZ), major depressive disorder (MDD), and bipolar disorder (BD) are serious mental disorders with distinct diagnostic criteria. They share common clinical and biological features. However, there are still only few studies on the common and specific brain imaging changes associated with the three mental disorders. Therefore, the aim of this study was to identify the common and specific functional activity and connectivity changes in SZ, MDD, and BD.Methods: A total of 271 individuals underwent functional magnetic resonance imaging: SZ (n = 64), MDD (n = 73), BD (n = 41), and healthy controls (n = 93). The symptoms of SZ patients were evaluated by the Positive and Negative Syndrome Scale. The Beck Depression Inventory (BDI), and Beck Anxiety Inventory (BAI) were used to evaluate the symptoms of MDD patients. The BDI, BAI, and Young Mania Rating Scale were used to evaluate the symptoms of MDD and BD patients. In addition, we compared the fALFF and functional connectivity between the three mental disorders and healthy controls using two sample t-tests.Results: Significantly decreased functional activity was found in the right superior frontal gyrus, middle cingulate gyrus, left middle frontal gyrus, and decreased functional connectivity (FC) of the insula was found in SZ, MDD, and BD. Specific fALFF changes, mainly in the ventral lateral pre-frontal cortex, striatum, and thalamus were found for SZ, in the left motor cortex and parietal lobe for MDD, and the dorsal lateral pre-frontal cortex, orbitofrontal cortex, and posterior cingulate cortex in BD.Conclusion: Our findings of common abnormalities in SZ, MDD, and BD provide evidence that salience network abnormality may play a critical role in the pathogenesis of these three mental disorders. Meanwhile, our findings also indicate that specific alterations in SZ, MDD, and BD provide neuroimaging evidence for the differential diagnosis of the three mental disorders. |
| first_indexed | 2024-12-23T21:34:32Z |
| format | Article |
| id | doaj.art-3c7242a12ff94a2fbc0017913849b817 |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-12-23T21:34:32Z |
| publishDate | 2019-02-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Psychiatry |
| spelling | doaj.art-3c7242a12ff94a2fbc0017913849b8172022-12-21T17:30:20ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402019-02-011010.3389/fpsyt.2019.00052428719Common and Specific Functional Activity Features in Schizophrenia, Major Depressive Disorder, and Bipolar DisorderYongfeng Yang0Yongfeng Yang1Yongfeng Yang2Shu Liu3Shu Liu4Xiaoyan Jiang5Hongyan Yu6Shuang Ding7Shuang Ding8Yanli Lu9Yanli Lu10Wenqiang Li11Wenqiang Li12Hongxing Zhang13Hongxing Zhang14Bing Liu15Bing Liu16Bing Liu17Yue Cui18Yue Cui19Yue Cui20Lingzhong Fan21Lingzhong Fan22Lingzhong Fan23Tianzi Jiang24Tianzi Jiang25Tianzi Jiang26Tianzi Jiang27Tianzi Jiang28Luxian Lv29Luxian Lv30Key Laboratory for Neuroinformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, ChinaDepartment of Psychiatry, Henan Mental Hospital, The Second Affiliated Hospital of Xinxiang Medical University, Xinxiang, ChinaHenan Key Laboratory of Biological Psychiatry, Xinxiang Medical University, Xinxiang, ChinaBrainnetome Center, Institute of Automation, Chinese Academy of Sciences, Beijing, ChinaNational Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, ChinaKey Laboratory for Neuroinformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, ChinaDepartment of Psychiatry, Henan Mental Hospital, The Second Affiliated Hospital of Xinxiang Medical University, Xinxiang, ChinaDepartment of Psychiatry, Henan Mental Hospital, The Second Affiliated Hospital of Xinxiang Medical University, Xinxiang, ChinaHenan Key Laboratory of Biological Psychiatry, Xinxiang Medical University, Xinxiang, ChinaDepartment of Psychiatry, Henan Mental Hospital, The Second Affiliated Hospital of Xinxiang Medical University, Xinxiang, ChinaHenan Key Laboratory of Biological Psychiatry, Xinxiang Medical University, Xinxiang, ChinaDepartment of Psychiatry, Henan Mental Hospital, The Second Affiliated Hospital of Xinxiang Medical University, Xinxiang, ChinaHenan Key Laboratory of Biological Psychiatry, Xinxiang Medical University, Xinxiang, ChinaDepartment of Psychiatry, Henan Mental Hospital, The Second Affiliated Hospital of Xinxiang Medical University, Xinxiang, ChinaHenan Key Laboratory of Biological Psychiatry, Xinxiang Medical University, Xinxiang, ChinaBrainnetome Center, Institute of Automation, Chinese Academy of Sciences, Beijing, ChinaNational Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, ChinaUniversity of Chinese Academy of Sciences, Beijing, ChinaBrainnetome Center, Institute of Automation, Chinese Academy of Sciences, Beijing, ChinaNational Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, ChinaUniversity of Chinese Academy of Sciences, Beijing, ChinaBrainnetome Center, Institute of Automation, Chinese Academy of Sciences, Beijing, ChinaNational Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, ChinaUniversity of Chinese Academy of Sciences, Beijing, ChinaKey Laboratory for Neuroinformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, ChinaBrainnetome Center, Institute of Automation, Chinese Academy of Sciences, Beijing, ChinaNational Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, ChinaUniversity of Chinese Academy of Sciences, Beijing, ChinaThe Queensland Brain Institute, University of Queensland, Brisbane, QLD, AustraliaDepartment of Psychiatry, Henan Mental Hospital, The Second Affiliated Hospital of Xinxiang Medical University, Xinxiang, ChinaHenan Key Laboratory of Biological Psychiatry, Xinxiang Medical University, Xinxiang, ChinaObjectives: Schizophrenia (SZ), major depressive disorder (MDD), and bipolar disorder (BD) are serious mental disorders with distinct diagnostic criteria. They share common clinical and biological features. However, there are still only few studies on the common and specific brain imaging changes associated with the three mental disorders. Therefore, the aim of this study was to identify the common and specific functional activity and connectivity changes in SZ, MDD, and BD.Methods: A total of 271 individuals underwent functional magnetic resonance imaging: SZ (n = 64), MDD (n = 73), BD (n = 41), and healthy controls (n = 93). The symptoms of SZ patients were evaluated by the Positive and Negative Syndrome Scale. The Beck Depression Inventory (BDI), and Beck Anxiety Inventory (BAI) were used to evaluate the symptoms of MDD patients. The BDI, BAI, and Young Mania Rating Scale were used to evaluate the symptoms of MDD and BD patients. In addition, we compared the fALFF and functional connectivity between the three mental disorders and healthy controls using two sample t-tests.Results: Significantly decreased functional activity was found in the right superior frontal gyrus, middle cingulate gyrus, left middle frontal gyrus, and decreased functional connectivity (FC) of the insula was found in SZ, MDD, and BD. Specific fALFF changes, mainly in the ventral lateral pre-frontal cortex, striatum, and thalamus were found for SZ, in the left motor cortex and parietal lobe for MDD, and the dorsal lateral pre-frontal cortex, orbitofrontal cortex, and posterior cingulate cortex in BD.Conclusion: Our findings of common abnormalities in SZ, MDD, and BD provide evidence that salience network abnormality may play a critical role in the pathogenesis of these three mental disorders. Meanwhile, our findings also indicate that specific alterations in SZ, MDD, and BD provide neuroimaging evidence for the differential diagnosis of the three mental disorders.https://www.frontiersin.org/article/10.3389/fpsyt.2019.00052/fullschizophreniamajor depressive disorderbipolar disordermagnetic resonance imagingfunctional activity |
| spellingShingle | Yongfeng Yang Yongfeng Yang Yongfeng Yang Shu Liu Shu Liu Xiaoyan Jiang Hongyan Yu Shuang Ding Shuang Ding Yanli Lu Yanli Lu Wenqiang Li Wenqiang Li Hongxing Zhang Hongxing Zhang Bing Liu Bing Liu Bing Liu Yue Cui Yue Cui Yue Cui Lingzhong Fan Lingzhong Fan Lingzhong Fan Tianzi Jiang Tianzi Jiang Tianzi Jiang Tianzi Jiang Tianzi Jiang Luxian Lv Luxian Lv Common and Specific Functional Activity Features in Schizophrenia, Major Depressive Disorder, and Bipolar Disorder Frontiers in Psychiatry schizophrenia major depressive disorder bipolar disorder magnetic resonance imaging functional activity |
| title | Common and Specific Functional Activity Features in Schizophrenia, Major Depressive Disorder, and Bipolar Disorder |
| title_full | Common and Specific Functional Activity Features in Schizophrenia, Major Depressive Disorder, and Bipolar Disorder |
| title_fullStr | Common and Specific Functional Activity Features in Schizophrenia, Major Depressive Disorder, and Bipolar Disorder |
| title_full_unstemmed | Common and Specific Functional Activity Features in Schizophrenia, Major Depressive Disorder, and Bipolar Disorder |
| title_short | Common and Specific Functional Activity Features in Schizophrenia, Major Depressive Disorder, and Bipolar Disorder |
| title_sort | common and specific functional activity features in schizophrenia major depressive disorder and bipolar disorder |
| topic | schizophrenia major depressive disorder bipolar disorder magnetic resonance imaging functional activity |
| url | https://www.frontiersin.org/article/10.3389/fpsyt.2019.00052/full |
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