Metabolic Syndrome Programming and Reprogramming: Mechanistic Aspects of Oxidative Stress
Metabolic syndrome (MetS) is a worldwide public health issue characterized by a set of risk factors for cardiovascular disease. MetS can originate in early life by developmental programming. Increasing evidence suggests that oxidative stress, which is characterized as an imbalance between reactive o...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/11/11/2108 |
| _version_ | 1797469264360243200 |
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| author | You-Lin Tain Chien-Ning Hsu |
| author_facet | You-Lin Tain Chien-Ning Hsu |
| author_sort | You-Lin Tain |
| collection | DOAJ |
| description | Metabolic syndrome (MetS) is a worldwide public health issue characterized by a set of risk factors for cardiovascular disease. MetS can originate in early life by developmental programming. Increasing evidence suggests that oxidative stress, which is characterized as an imbalance between reactive oxygen species (ROS), nitric oxide (NO), and antioxidant systems, plays a decisive role in MetS programming. Results from human and animal studies indicate that maternal-derived insults induce MetS later in life, accompanied by oxidative stress programming of various organ systems. On the contrary, perinatal use of antioxidants can offset oxidative stress and thereby prevent MetS traits in adult offspring. This review provides an overview of current knowledge about the core mechanisms behind MetS programming, with particular focus on the occurrence of oxidative-stress-related pathogenesis as well as the use of potential oxidative-stress-targeted interventions as a reprogramming strategy to avert MetS of developmental origins. Future clinical studies should provide important proof of concept for the effectiveness of these reprogramming interventions to prevent a MetS epidemic. |
| first_indexed | 2024-03-09T19:18:56Z |
| format | Article |
| id | doaj.art-3c7344fe478c4914a4581eec34c70b16 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-09T19:18:56Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-3c7344fe478c4914a4581eec34c70b162023-11-24T03:29:21ZengMDPI AGAntioxidants2076-39212022-10-011111210810.3390/antiox11112108Metabolic Syndrome Programming and Reprogramming: Mechanistic Aspects of Oxidative StressYou-Lin Tain0Chien-Ning Hsu1Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, TaiwanDepartment of Pharmacy, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, TaiwanMetabolic syndrome (MetS) is a worldwide public health issue characterized by a set of risk factors for cardiovascular disease. MetS can originate in early life by developmental programming. Increasing evidence suggests that oxidative stress, which is characterized as an imbalance between reactive oxygen species (ROS), nitric oxide (NO), and antioxidant systems, plays a decisive role in MetS programming. Results from human and animal studies indicate that maternal-derived insults induce MetS later in life, accompanied by oxidative stress programming of various organ systems. On the contrary, perinatal use of antioxidants can offset oxidative stress and thereby prevent MetS traits in adult offspring. This review provides an overview of current knowledge about the core mechanisms behind MetS programming, with particular focus on the occurrence of oxidative-stress-related pathogenesis as well as the use of potential oxidative-stress-targeted interventions as a reprogramming strategy to avert MetS of developmental origins. Future clinical studies should provide important proof of concept for the effectiveness of these reprogramming interventions to prevent a MetS epidemic.https://www.mdpi.com/2076-3921/11/11/2108oxidative stressreactive oxygen speciesantioxidantdevelopmental origins of health and disease (DOHaD)nitric oxideobesity |
| spellingShingle | You-Lin Tain Chien-Ning Hsu Metabolic Syndrome Programming and Reprogramming: Mechanistic Aspects of Oxidative Stress Antioxidants oxidative stress reactive oxygen species antioxidant developmental origins of health and disease (DOHaD) nitric oxide obesity |
| title | Metabolic Syndrome Programming and Reprogramming: Mechanistic Aspects of Oxidative Stress |
| title_full | Metabolic Syndrome Programming and Reprogramming: Mechanistic Aspects of Oxidative Stress |
| title_fullStr | Metabolic Syndrome Programming and Reprogramming: Mechanistic Aspects of Oxidative Stress |
| title_full_unstemmed | Metabolic Syndrome Programming and Reprogramming: Mechanistic Aspects of Oxidative Stress |
| title_short | Metabolic Syndrome Programming and Reprogramming: Mechanistic Aspects of Oxidative Stress |
| title_sort | metabolic syndrome programming and reprogramming mechanistic aspects of oxidative stress |
| topic | oxidative stress reactive oxygen species antioxidant developmental origins of health and disease (DOHaD) nitric oxide obesity |
| url | https://www.mdpi.com/2076-3921/11/11/2108 |
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