Relationship between Medication-Related Osteonecrosis of the Jaw and CDK4/6 Inhibitors in Breast Cancer
Objective: We aimed to evaluate the use of CDK4/6 inhibitors as a risk factor for medication-related osteonecrosis of the jaw (MRONJ) in a cohort of patients with metastatic breast cancer treated with denosumab. Methods: This was a multicentre, retrospective, observational study. All patients with b...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-01-01
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| Series: | Current Oncology |
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| Online Access: | https://www.mdpi.com/1718-7729/31/1/16 |
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| author | Loreto Domínguez Senín David Morales Pancorbo María Yeray Rodríguez Garcés María Dolores Santos-Rubio Juan Bayo Calero |
| author_facet | Loreto Domínguez Senín David Morales Pancorbo María Yeray Rodríguez Garcés María Dolores Santos-Rubio Juan Bayo Calero |
| author_sort | Loreto Domínguez Senín |
| collection | DOAJ |
| description | Objective: We aimed to evaluate the use of CDK4/6 inhibitors as a risk factor for medication-related osteonecrosis of the jaw (MRONJ) in a cohort of patients with metastatic breast cancer treated with denosumab. Methods: This was a multicentre, retrospective, observational study. All patients with breast cancer treated with denosumab (January 2011–December 2022) were included. The relationship between CDK4/6 inhibitors and MRONJ was analysed. Results: A total of 243 patients were included, ninety-five (44.2%) of whom used a CDK4/6 inhibitor. There were 21 patients with MRONJ. In patients treated with denosumab without CDK4/6 inhibitors, the incidence of MRONJ and mean time to the occurrence of MRONJ were 6.6% (8/120) and 16.8 months (SD 7.8), respectively; in patients treated with denosumab and CDK4/6 inhibitor, these values were 13.7% (13/95) and 15.4 months (SD 8.7), respectively. The difference in the incidence was not significant (<i>p</i> = 0.085). Among the 19 patients who used abemaciclib, the probability of MRONJ occurrence was significantly higher compared to patients not using CDK4/6 inhibitors (<i>p</i> = 0.0178). Conclusions: These results suggest that the incidence of MRONJ in patients with metastatic breast cancer treated with denosumab is higher, and the onset of MRONJ occurs earlier in the presence of CDK4/6 inhibitors. The differences were statistically significant in the patients who used abemaciclib. Given that the use of this combination is very common in routine clinical practice, it would be advisable to carry out larger prospective studies to clarify the risk of this association. |
| first_indexed | 2024-03-08T11:00:58Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1198-0052 1718-7729 |
| language | English |
| last_indexed | 2024-03-08T11:00:58Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Oncology |
| spelling | doaj.art-3c73cc0bf2b1469588603ae7d5ee38242024-01-26T15:57:46ZengMDPI AGCurrent Oncology1198-00521718-77292024-01-0131125025910.3390/curroncol31010016Relationship between Medication-Related Osteonecrosis of the Jaw and CDK4/6 Inhibitors in Breast CancerLoreto Domínguez Senín0David Morales Pancorbo1María Yeray Rodríguez Garcés2María Dolores Santos-Rubio3Juan Bayo Calero4Hospital Pharmacy, Juan Ramón Jiménez University Hospital, 21005 Huelva, SpainDepartment of Medical Oncology, Juan Ramón Jiménez University Hospital, 21005 Huelva, SpainDepartment of Medical Oncology, Riotinto Hospital, 21660 Huelva, SpainHospital Pharmacy, Juan Ramón Jiménez University Hospital, 21005 Huelva, SpainDepartment of Medical Oncology, Juan Ramón Jiménez University Hospital, 21005 Huelva, SpainObjective: We aimed to evaluate the use of CDK4/6 inhibitors as a risk factor for medication-related osteonecrosis of the jaw (MRONJ) in a cohort of patients with metastatic breast cancer treated with denosumab. Methods: This was a multicentre, retrospective, observational study. All patients with breast cancer treated with denosumab (January 2011–December 2022) were included. The relationship between CDK4/6 inhibitors and MRONJ was analysed. Results: A total of 243 patients were included, ninety-five (44.2%) of whom used a CDK4/6 inhibitor. There were 21 patients with MRONJ. In patients treated with denosumab without CDK4/6 inhibitors, the incidence of MRONJ and mean time to the occurrence of MRONJ were 6.6% (8/120) and 16.8 months (SD 7.8), respectively; in patients treated with denosumab and CDK4/6 inhibitor, these values were 13.7% (13/95) and 15.4 months (SD 8.7), respectively. The difference in the incidence was not significant (<i>p</i> = 0.085). Among the 19 patients who used abemaciclib, the probability of MRONJ occurrence was significantly higher compared to patients not using CDK4/6 inhibitors (<i>p</i> = 0.0178). Conclusions: These results suggest that the incidence of MRONJ in patients with metastatic breast cancer treated with denosumab is higher, and the onset of MRONJ occurs earlier in the presence of CDK4/6 inhibitors. The differences were statistically significant in the patients who used abemaciclib. Given that the use of this combination is very common in routine clinical practice, it would be advisable to carry out larger prospective studies to clarify the risk of this association.https://www.mdpi.com/1718-7729/31/1/16MRONJCDK4/6 inhibitorsmetastatic breast canceroral epidemiology |
| spellingShingle | Loreto Domínguez Senín David Morales Pancorbo María Yeray Rodríguez Garcés María Dolores Santos-Rubio Juan Bayo Calero Relationship between Medication-Related Osteonecrosis of the Jaw and CDK4/6 Inhibitors in Breast Cancer Current Oncology MRONJ CDK4/6 inhibitors metastatic breast cancer oral epidemiology |
| title | Relationship between Medication-Related Osteonecrosis of the Jaw and CDK4/6 Inhibitors in Breast Cancer |
| title_full | Relationship between Medication-Related Osteonecrosis of the Jaw and CDK4/6 Inhibitors in Breast Cancer |
| title_fullStr | Relationship between Medication-Related Osteonecrosis of the Jaw and CDK4/6 Inhibitors in Breast Cancer |
| title_full_unstemmed | Relationship between Medication-Related Osteonecrosis of the Jaw and CDK4/6 Inhibitors in Breast Cancer |
| title_short | Relationship between Medication-Related Osteonecrosis of the Jaw and CDK4/6 Inhibitors in Breast Cancer |
| title_sort | relationship between medication related osteonecrosis of the jaw and cdk4 6 inhibitors in breast cancer |
| topic | MRONJ CDK4/6 inhibitors metastatic breast cancer oral epidemiology |
| url | https://www.mdpi.com/1718-7729/31/1/16 |
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