Abrine, an IDO1 inhibitor, suppresses the immune escape and enhances the immunotherapy of anti-PD-1 antibody in hepatocellular carcinoma

Abrine, an IDO1 inhibitor, suppresses the immune escape and enhances the immunotherapy of anti-PD-1 antibody in hepatocellular carcinoma

BackgroundIndoleamine-2,3-dioxygenase 1 (IDO1) is responsible for tumor immune escape by regulating T cell-associated immune responses and promoting the activation of immunosuppressive. Given the vital role of IDO1 in immune response, further investigation on the regulation of IDO1 in tumors is need...

Full description

Bibliographic Details
Main Authors: Xiaowei Liang, Hongwei Gao, Jian Xiao, Shan Han, Jia He, Renyikun Yuan, Shilin Yang, Chun Yao
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Immunology
Subjects:
IDO1
Abrine
CD47
PD-L1
m6A RNA modification
immune escape
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1185985/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1185985/full

Similar Items