Characteristics of phenotypes of elderly patients with asthma
Background: The characteristics of phenotypes of elderly patients with asthma are unknown. The aim of this study was to classify these phenotypes using lung function tests and images from high-resolution computed tomography (HRCT), and to identify associations between clinical characteristics and ph...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2016-04-01
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| Series: | Allergology International |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1323893015002142 |
| _version_ | 1811239206403440640 |
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| author | Hiroyuki Sano Takashi Iwanaga Osamu Nishiyama Akiko Sano Yuji Higashimoto Katsuyuki Tomita Yuji Tohda |
| author_facet | Hiroyuki Sano Takashi Iwanaga Osamu Nishiyama Akiko Sano Yuji Higashimoto Katsuyuki Tomita Yuji Tohda |
| author_sort | Hiroyuki Sano |
| collection | DOAJ |
| description | Background: The characteristics of phenotypes of elderly patients with asthma are unknown. The aim of this study was to classify these phenotypes using lung function tests and images from high-resolution computed tomography (HRCT), and to identify associations between clinical characteristics and phenotypes.
Methods: A cross-sectional study was conducted in 165 elderly patients (>65 years of age) who underwent a multidimensional assessment of clinical and functional status and comorbidity. The patients were divided into three phenotypes: (1) asthma-predominant, (2) asthma-obstructive airway disease (OAD) overlap without emphysema, and (3) asthma-OAD overlap with emphysema (asthma-emphysema overlap) based on chest HRCT. A receiver operating characteristic (ROC) curve was constructed to evaluate the cutoff for differentiating between the two OAD phenotypes. Multivariate analysis was also used to distinguish between these two phenotypes.
Results: The phenotypes were asthma-predominant in 48 patients (29%), asthma-OAD without emphysema in 36 (22%), and asthma-emphysema in 81 (49%). Patients with asthma-emphysema were more frequent smokers. In multivariate analysis, smoking status (odds ratio 2.92: 95% CI 1.21–7.00, P = 0.03) and % predicted FEV1 ≤70% (odds ratio 3.18: 95% CI 1.13–8.92, P = 0.03) differed significantly between the asthma-emphysema and asthma-OAD without emphysema phenotypes.
Conclusions: Half of elderly patients with asthma are characterized by asthma-emphysema overlap. Our results showed that elderly patients with asthma who are smokers and have moderate or severe OAD are also likely to have emphysema. |
| first_indexed | 2024-04-12T12:55:40Z |
| format | Article |
| id | doaj.art-3c7766f7cc054b61b7a29be641896656 |
| institution | Directory Open Access Journal |
| issn | 1323-8930 |
| language | English |
| last_indexed | 2024-04-12T12:55:40Z |
| publishDate | 2016-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Allergology International |
| spelling | doaj.art-3c7766f7cc054b61b7a29be6418966562022-12-22T03:32:20ZengElsevierAllergology International1323-89302016-04-0165220420910.1016/j.alit.2015.11.007Characteristics of phenotypes of elderly patients with asthmaHiroyuki SanoTakashi IwanagaOsamu NishiyamaAkiko SanoYuji HigashimotoKatsuyuki TomitaYuji TohdaBackground: The characteristics of phenotypes of elderly patients with asthma are unknown. The aim of this study was to classify these phenotypes using lung function tests and images from high-resolution computed tomography (HRCT), and to identify associations between clinical characteristics and phenotypes. Methods: A cross-sectional study was conducted in 165 elderly patients (>65 years of age) who underwent a multidimensional assessment of clinical and functional status and comorbidity. The patients were divided into three phenotypes: (1) asthma-predominant, (2) asthma-obstructive airway disease (OAD) overlap without emphysema, and (3) asthma-OAD overlap with emphysema (asthma-emphysema overlap) based on chest HRCT. A receiver operating characteristic (ROC) curve was constructed to evaluate the cutoff for differentiating between the two OAD phenotypes. Multivariate analysis was also used to distinguish between these two phenotypes. Results: The phenotypes were asthma-predominant in 48 patients (29%), asthma-OAD without emphysema in 36 (22%), and asthma-emphysema in 81 (49%). Patients with asthma-emphysema were more frequent smokers. In multivariate analysis, smoking status (odds ratio 2.92: 95% CI 1.21–7.00, P = 0.03) and % predicted FEV1 ≤70% (odds ratio 3.18: 95% CI 1.13–8.92, P = 0.03) differed significantly between the asthma-emphysema and asthma-OAD without emphysema phenotypes. Conclusions: Half of elderly patients with asthma are characterized by asthma-emphysema overlap. Our results showed that elderly patients with asthma who are smokers and have moderate or severe OAD are also likely to have emphysema.http://www.sciencedirect.com/science/article/pii/S1323893015002142ACOSElderly asthmaEmphysemaHRCTPhenotype |
| spellingShingle | Hiroyuki Sano Takashi Iwanaga Osamu Nishiyama Akiko Sano Yuji Higashimoto Katsuyuki Tomita Yuji Tohda Characteristics of phenotypes of elderly patients with asthma Allergology International ACOS Elderly asthma Emphysema HRCT Phenotype |
| title | Characteristics of phenotypes of elderly patients with asthma |
| title_full | Characteristics of phenotypes of elderly patients with asthma |
| title_fullStr | Characteristics of phenotypes of elderly patients with asthma |
| title_full_unstemmed | Characteristics of phenotypes of elderly patients with asthma |
| title_short | Characteristics of phenotypes of elderly patients with asthma |
| title_sort | characteristics of phenotypes of elderly patients with asthma |
| topic | ACOS Elderly asthma Emphysema HRCT Phenotype |
| url | http://www.sciencedirect.com/science/article/pii/S1323893015002142 |
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