A TOX-ic axis of epigenetic stem cell maintenance and chemoresistance in colon cancer.
Cancer stem cells drive tumor growth and survival via self-renewal and therapeutic resistance, but the upstream mechanisms are not well defined. In this issue of PLOS Biology, a study in colon cancer reveals a new signalling network that links epigenetic regulation to these phenotypes.
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2023-09-01
|
| Series: | PLoS Biology |
| Online Access: | https://doi.org/10.1371/journal.pbio.3002295 |
| _version_ | 1797680684112805888 |
|---|---|
| author | Christopher G Hubert Shaun R Stauffer Justin D Lathia |
| author_facet | Christopher G Hubert Shaun R Stauffer Justin D Lathia |
| author_sort | Christopher G Hubert |
| collection | DOAJ |
| description | Cancer stem cells drive tumor growth and survival via self-renewal and therapeutic resistance, but the upstream mechanisms are not well defined. In this issue of PLOS Biology, a study in colon cancer reveals a new signalling network that links epigenetic regulation to these phenotypes. |
| first_indexed | 2024-03-11T23:33:36Z |
| format | Article |
| id | doaj.art-3c78a5a10ba144b49943c87807187a2a |
| institution | Directory Open Access Journal |
| issn | 1544-9173 1545-7885 |
| language | English |
| last_indexed | 2024-03-11T23:33:36Z |
| publishDate | 2023-09-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Biology |
| spelling | doaj.art-3c78a5a10ba144b49943c87807187a2a2023-09-20T05:31:04ZengPublic Library of Science (PLoS)PLoS Biology1544-91731545-78852023-09-01219e300229510.1371/journal.pbio.3002295A TOX-ic axis of epigenetic stem cell maintenance and chemoresistance in colon cancer.Christopher G HubertShaun R StaufferJustin D LathiaCancer stem cells drive tumor growth and survival via self-renewal and therapeutic resistance, but the upstream mechanisms are not well defined. In this issue of PLOS Biology, a study in colon cancer reveals a new signalling network that links epigenetic regulation to these phenotypes.https://doi.org/10.1371/journal.pbio.3002295 |
| spellingShingle | Christopher G Hubert Shaun R Stauffer Justin D Lathia A TOX-ic axis of epigenetic stem cell maintenance and chemoresistance in colon cancer. PLoS Biology |
| title | A TOX-ic axis of epigenetic stem cell maintenance and chemoresistance in colon cancer. |
| title_full | A TOX-ic axis of epigenetic stem cell maintenance and chemoresistance in colon cancer. |
| title_fullStr | A TOX-ic axis of epigenetic stem cell maintenance and chemoresistance in colon cancer. |
| title_full_unstemmed | A TOX-ic axis of epigenetic stem cell maintenance and chemoresistance in colon cancer. |
| title_short | A TOX-ic axis of epigenetic stem cell maintenance and chemoresistance in colon cancer. |
| title_sort | tox ic axis of epigenetic stem cell maintenance and chemoresistance in colon cancer |
| url | https://doi.org/10.1371/journal.pbio.3002295 |
| work_keys_str_mv | AT christopherghubert atoxicaxisofepigeneticstemcellmaintenanceandchemoresistanceincoloncancer AT shaunrstauffer atoxicaxisofepigeneticstemcellmaintenanceandchemoresistanceincoloncancer AT justindlathia atoxicaxisofepigeneticstemcellmaintenanceandchemoresistanceincoloncancer AT christopherghubert toxicaxisofepigeneticstemcellmaintenanceandchemoresistanceincoloncancer AT shaunrstauffer toxicaxisofepigeneticstemcellmaintenanceandchemoresistanceincoloncancer AT justindlathia toxicaxisofepigeneticstemcellmaintenanceandchemoresistanceincoloncancer |