Efficacy of Antisecretory Agents in Cardiosurgical Patients in the Early Postoperative Period
Objective. To compare the efficacy of antisecretory agents used to prevent early postoperative mucosal erosive and ulcerative lesions of the upper gastrointestinal tract (GIT) in patients undergone cardiac surgery under extracorporeal circulation (EC). The study was performed by stratification rando...
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| Format: | Article |
| Language: | English |
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Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia
2006-02-01
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| Series: | Общая реаниматология |
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| Online Access: | https://www.reanimatology.com/rmt/article/view/1201 |
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| author | M. B. Yarustovsky Ye. A. Shipova A. V. Bobkova T. K. Khaidurova |
| author_facet | M. B. Yarustovsky Ye. A. Shipova A. V. Bobkova T. K. Khaidurova |
| author_sort | M. B. Yarustovsky |
| collection | DOAJ |
| description | Objective. To compare the efficacy of antisecretory agents used to prevent early postoperative mucosal erosive and ulcerative lesions of the upper gastrointestinal tract (GIT) in patients undergone cardiac surgery under extracorporeal circulation (EC). The study was performed by stratification randomization. Sixty-three adult patients with acquired cardiac diseases who had undergone operations on the heart under EC were clinically and endoscopically examined. To prevent acute proximal GIT ulcerations in the early postoperative period, all the patients were given antisecretory agents: ^-histamine receptor blockers or proton pump inhibitors (PPI). A drug was chosen by the blind method (envelope one). One group (n=31) took ^-histamine receptor blockers, the other (n=32) received PPI (omeprazole). To examine the upper GIT mucosa and to determine gastric acid-producing function, esophagogastroduodenoscopy with parietal pH-metry and chromoscopy were performed on postoperative days 5 and 9. Analysis of the findings revealed acute erosive and ulcerative lesions in 12.7% of all the examinees only in the ^-blocker group. Suppressed hydrochloric acid was significantly pronounced in the PPI group, as evidenced by chromoscopy. In the H2-blocker and PPI groups, the mean gastric pH value was 2.4±1.0 and 5.5±06 (F=224 and 259, respectively; p=0.0001). |
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| format | Article |
| id | doaj.art-3c792763020f44f9b29d91fca7aeb458 |
| institution | Directory Open Access Journal |
| issn | 1813-9779 2411-7110 |
| language | English |
| last_indexed | 2025-03-14T09:47:39Z |
| publishDate | 2006-02-01 |
| publisher | Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia |
| record_format | Article |
| series | Общая реаниматология |
| spelling | doaj.art-3c792763020f44f9b29d91fca7aeb4582025-03-02T11:29:25ZengFederal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, RussiaОбщая реаниматология1813-97792411-71102006-02-0121596410.15360/1813-9779-2006-1-59-641201Efficacy of Antisecretory Agents in Cardiosurgical Patients in the Early Postoperative PeriodM. B. Yarustovsky0Ye. A. Shipova1A. V. Bobkova2T. K. Khaidurova3A. N. Bakulev Research Center of Cardiovascular Surgery, Russian Academy of Medical Sciences, MoscowA. N. Bakulev Research Center of Cardiovascular Surgery, Russian Academy of Medical Sciences, MoscowA. N. Bakulev Research Center of Cardiovascular Surgery, Russian Academy of Medical Sciences, MoscowA. N. Bakulev Research Center of Cardiovascular Surgery, Russian Academy of Medical Sciences, MoscowObjective. To compare the efficacy of antisecretory agents used to prevent early postoperative mucosal erosive and ulcerative lesions of the upper gastrointestinal tract (GIT) in patients undergone cardiac surgery under extracorporeal circulation (EC). The study was performed by stratification randomization. Sixty-three adult patients with acquired cardiac diseases who had undergone operations on the heart under EC were clinically and endoscopically examined. To prevent acute proximal GIT ulcerations in the early postoperative period, all the patients were given antisecretory agents: ^-histamine receptor blockers or proton pump inhibitors (PPI). A drug was chosen by the blind method (envelope one). One group (n=31) took ^-histamine receptor blockers, the other (n=32) received PPI (omeprazole). To examine the upper GIT mucosa and to determine gastric acid-producing function, esophagogastroduodenoscopy with parietal pH-metry and chromoscopy were performed on postoperative days 5 and 9. Analysis of the findings revealed acute erosive and ulcerative lesions in 12.7% of all the examinees only in the ^-blocker group. Suppressed hydrochloric acid was significantly pronounced in the PPI group, as evidenced by chromoscopy. In the H2-blocker and PPI groups, the mean gastric pH value was 2.4±1.0 and 5.5±06 (F=224 and 259, respectively; p=0.0001).https://www.reanimatology.com/rmt/article/view/1201postoperative periodantisecretory agents |
| spellingShingle | M. B. Yarustovsky Ye. A. Shipova A. V. Bobkova T. K. Khaidurova Efficacy of Antisecretory Agents in Cardiosurgical Patients in the Early Postoperative Period Общая реаниматология postoperative period antisecretory agents |
| title | Efficacy of Antisecretory Agents in Cardiosurgical Patients in the Early Postoperative Period |
| title_full | Efficacy of Antisecretory Agents in Cardiosurgical Patients in the Early Postoperative Period |
| title_fullStr | Efficacy of Antisecretory Agents in Cardiosurgical Patients in the Early Postoperative Period |
| title_full_unstemmed | Efficacy of Antisecretory Agents in Cardiosurgical Patients in the Early Postoperative Period |
| title_short | Efficacy of Antisecretory Agents in Cardiosurgical Patients in the Early Postoperative Period |
| title_sort | efficacy of antisecretory agents in cardiosurgical patients in the early postoperative period |
| topic | postoperative period antisecretory agents |
| url | https://www.reanimatology.com/rmt/article/view/1201 |
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