Menthol-loaded PLGA Micro and Nanospheres: Synthesis, Characterization and Degradation in Artificial Saliva
Menthol-loaded PLGA micro/nanospheres were synthesized using the multiple emulsion/solvent evaporation technique. Parameters such as stirring rate, external surfactant content, PLGA/menthol weight ratio, solvent evaporation and lyophilization time were evaluated as well as the degradation of micro/n...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Associação Brasileira de Metalurgia e Materiais (ABM); Associação Brasileira de Cerâmica (ABC); Associação Brasileira de Polímeros (ABPol)
2018-02-01
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| Series: | Materials Research |
| Subjects: | |
| Online Access: | http://www.scielo.br/pdf/mr/v21n2/1516-1439-mr-1980-5373-MR-2017-0488.pdf |
| _version_ | 1798026356638875648 |
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| author | Juliana Pelisoli Holz Marcia Karpinski Bottene Vanusca Dalosto Jahno Sandra Einloft Rosane Ligabue |
| author_facet | Juliana Pelisoli Holz Marcia Karpinski Bottene Vanusca Dalosto Jahno Sandra Einloft Rosane Ligabue |
| author_sort | Juliana Pelisoli Holz |
| collection | DOAJ |
| description | Menthol-loaded PLGA micro/nanospheres were synthesized using the multiple emulsion/solvent evaporation technique. Parameters such as stirring rate, external surfactant content, PLGA/menthol weight ratio, solvent evaporation and lyophilization time were evaluated as well as the degradation of micro/nanospheres in an artificial saliva medium. The menthol/PLGA micro/nanospheres thus obtained had a size distribution of between 217 nm and 13 µm and particles with spherical and dense morphology were evidenced by SEM micrographs. FTIR and TGA data showed an increase up to 60% of menthol incorporated in the micro/nanoparticles. The degradation of menthol-loaded PLGA micro/nanoparticles in artificial saliva significantly affected the particles morphology and appears to be an effective medium for releasing menthol. |
| first_indexed | 2024-04-11T18:35:14Z |
| format | Article |
| id | doaj.art-3c7b7f24dfe441bab4e62bad9c806550 |
| institution | Directory Open Access Journal |
| issn | 1516-1439 |
| language | English |
| last_indexed | 2024-04-11T18:35:14Z |
| publishDate | 2018-02-01 |
| publisher | Associação Brasileira de Metalurgia e Materiais (ABM); Associação Brasileira de Cerâmica (ABC); Associação Brasileira de Polímeros (ABPol) |
| record_format | Article |
| series | Materials Research |
| spelling | doaj.art-3c7b7f24dfe441bab4e62bad9c8065502022-12-22T04:09:19ZengAssociação Brasileira de Metalurgia e Materiais (ABM); Associação Brasileira de Cerâmica (ABC); Associação Brasileira de Polímeros (ABPol)Materials Research1516-14392018-02-0121210.1590/1980-5373-mr-2017-0488Menthol-loaded PLGA Micro and Nanospheres: Synthesis, Characterization and Degradation in Artificial SalivaJuliana Pelisoli HolzMarcia Karpinski BotteneVanusca Dalosto JahnoSandra Einlofthttps://orcid.org/0000-0003-1364-0325Rosane LigabueMenthol-loaded PLGA micro/nanospheres were synthesized using the multiple emulsion/solvent evaporation technique. Parameters such as stirring rate, external surfactant content, PLGA/menthol weight ratio, solvent evaporation and lyophilization time were evaluated as well as the degradation of micro/nanospheres in an artificial saliva medium. The menthol/PLGA micro/nanospheres thus obtained had a size distribution of between 217 nm and 13 µm and particles with spherical and dense morphology were evidenced by SEM micrographs. FTIR and TGA data showed an increase up to 60% of menthol incorporated in the micro/nanoparticles. The degradation of menthol-loaded PLGA micro/nanoparticles in artificial saliva significantly affected the particles morphology and appears to be an effective medium for releasing menthol.http://www.scielo.br/pdf/mr/v21n2/1516-1439-mr-1980-5373-MR-2017-0488.pdfemulsionmentholmicro/nanospheresPLGA |
| spellingShingle | Juliana Pelisoli Holz Marcia Karpinski Bottene Vanusca Dalosto Jahno Sandra Einloft Rosane Ligabue Menthol-loaded PLGA Micro and Nanospheres: Synthesis, Characterization and Degradation in Artificial Saliva Materials Research emulsion menthol micro/nanospheres PLGA |
| title | Menthol-loaded PLGA Micro and Nanospheres: Synthesis, Characterization and Degradation in Artificial Saliva |
| title_full | Menthol-loaded PLGA Micro and Nanospheres: Synthesis, Characterization and Degradation in Artificial Saliva |
| title_fullStr | Menthol-loaded PLGA Micro and Nanospheres: Synthesis, Characterization and Degradation in Artificial Saliva |
| title_full_unstemmed | Menthol-loaded PLGA Micro and Nanospheres: Synthesis, Characterization and Degradation in Artificial Saliva |
| title_short | Menthol-loaded PLGA Micro and Nanospheres: Synthesis, Characterization and Degradation in Artificial Saliva |
| title_sort | menthol loaded plga micro and nanospheres synthesis characterization and degradation in artificial saliva |
| topic | emulsion menthol micro/nanospheres PLGA |
| url | http://www.scielo.br/pdf/mr/v21n2/1516-1439-mr-1980-5373-MR-2017-0488.pdf |
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