Analgesic Activity of 5-Acetamido-2-Hydroxy Benzoic Acid Derivatives and an In-Vivo and In-Silico Analysis of Their Target Interactions

Analgesic Activity of 5-Acetamido-2-Hydroxy Benzoic Acid Derivatives and an In-Vivo and In-Silico Analysis of Their Target Interactions

The design, synthesis, and evaluation of novel non-steroidal anti-inflammatory drugs (NSAIDs) with better activity and lower side effects are big challenges today. In this work, two 5-acetamido-2-hydroxy benzoic acid derivatives were proposed, increasing the alkyl position (methyl) in an acetamide m...

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Bibliographic Details
Main Authors: Cleydson B. R. Santos, Cleison C. Lobato, Sirlene S. B. Ota, Rai C. Silva, Renata C. V. S. Bittencourt, Jofre J. S. Freitas, Elenilze F. B. Ferreira, Marília B. Ferreira, Renata C. Silva, Anderson B. De Lima, Joaquín M. Campos, Rosivaldo S. Borges, José A. H. M. Bittencourt
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:Pharmaceuticals
Subjects:
analgesic
5-acetamido-2-hydroxy benzoic acid
molecular docking
ADME
toxicity
Online Access:https://www.mdpi.com/1424-8247/16/11/1584

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