The exploration of bio-inspired copper oxide nanoparticles: synthesis, characterization and in-vitro biological investigations
The paper describes the synthesis and characterization of copper oxide nanoparticles (CuO NPs) using the mixture of plant rhizome extracts Ocimum sanctum and Saussurea lappa as a reducing agent. The prepared CuO nanoparticles are characterized and confirmed their formation based on data obtained fro...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-06-01
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| Series: | Heliyon |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844022010143 |
| _version_ | 1818215110545506304 |
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| author | Lalitha Ammadu Kolahalam K.R.S. Prasad P. Murali Krishna N. Supraja S. Shanmugan |
| author_facet | Lalitha Ammadu Kolahalam K.R.S. Prasad P. Murali Krishna N. Supraja S. Shanmugan |
| author_sort | Lalitha Ammadu Kolahalam |
| collection | DOAJ |
| description | The paper describes the synthesis and characterization of copper oxide nanoparticles (CuO NPs) using the mixture of plant rhizome extracts Ocimum sanctum and Saussurea lappa as a reducing agent. The prepared CuO nanoparticles are characterized and confirmed their formation based on data obtained from powder X-ray diffraction spectroscopy, Fourier Transmission Infrared, Ultraviolet-Visible spectra, Field Emission Scanning Electron Microscopy images, Energy Dispersive X-ray analysis and Dynamic light scattering techniques and data reveal that the average size of CuO Nps was 103.4 nm. The result of antibacterial and antifungal activities for concentrations 50, 100, and 170 ppm indicate that NPs may exhibit appreciable activity at higher (170 ppm) concentrations. The MTT cytotoxic assay studies of Chinese Hamster Ovary (CHO) cell lines showed a Half-maximal inhibitory concentration (IC50) value of 4.14 μg/mL. |
| first_indexed | 2024-12-12T06:30:52Z |
| format | Article |
| id | doaj.art-3c7e706cf36c4c2eb5358033e72abcd0 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-12-12T06:30:52Z |
| publishDate | 2022-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-3c7e706cf36c4c2eb5358033e72abcd02022-12-22T00:34:35ZengElsevierHeliyon2405-84402022-06-0186e09726The exploration of bio-inspired copper oxide nanoparticles: synthesis, characterization and in-vitro biological investigationsLalitha Ammadu Kolahalam0K.R.S. Prasad1P. Murali Krishna2N. Supraja3S. Shanmugan4Department of Chemistry, Koneru Lakshmaiah Education Foundation, Vaddeswaram, Guntur, 522502, Andhra Pradesh, IndiaDepartment of Chemistry, Koneru Lakshmaiah Education Foundation, Vaddeswaram, Guntur, 522502, Andhra Pradesh, India; Corresponding author.Department of Chemistry, Ramaiah Institute of Technology (Autonomous Institute, Affiliated to VTU), Bangalore, 560054, Karnataka, India; Corresponding author.Acharya N G Ranga Agricultural University, Nanotechnology Laboratory, RARS, Tirupati, 517502, Andhra Pradesh, IndiaResearch Centre for Solar Energy, Department of Physics, Koneru Lakshmaiah Education Foundation, Vaddeswaram, Guntur, 522502, Andhra Pradesh, IndiaThe paper describes the synthesis and characterization of copper oxide nanoparticles (CuO NPs) using the mixture of plant rhizome extracts Ocimum sanctum and Saussurea lappa as a reducing agent. The prepared CuO nanoparticles are characterized and confirmed their formation based on data obtained from powder X-ray diffraction spectroscopy, Fourier Transmission Infrared, Ultraviolet-Visible spectra, Field Emission Scanning Electron Microscopy images, Energy Dispersive X-ray analysis and Dynamic light scattering techniques and data reveal that the average size of CuO Nps was 103.4 nm. The result of antibacterial and antifungal activities for concentrations 50, 100, and 170 ppm indicate that NPs may exhibit appreciable activity at higher (170 ppm) concentrations. The MTT cytotoxic assay studies of Chinese Hamster Ovary (CHO) cell lines showed a Half-maximal inhibitory concentration (IC50) value of 4.14 μg/mL.http://www.sciencedirect.com/science/article/pii/S2405844022010143Copper oxide nanoparticlesAntibacterialAntifungalCytotoxic activityOcimum sanctum and Saussurea lappa plant extracts |
| spellingShingle | Lalitha Ammadu Kolahalam K.R.S. Prasad P. Murali Krishna N. Supraja S. Shanmugan The exploration of bio-inspired copper oxide nanoparticles: synthesis, characterization and in-vitro biological investigations Heliyon Copper oxide nanoparticles Antibacterial Antifungal Cytotoxic activity Ocimum sanctum and Saussurea lappa plant extracts |
| title | The exploration of bio-inspired copper oxide nanoparticles: synthesis, characterization and in-vitro biological investigations |
| title_full | The exploration of bio-inspired copper oxide nanoparticles: synthesis, characterization and in-vitro biological investigations |
| title_fullStr | The exploration of bio-inspired copper oxide nanoparticles: synthesis, characterization and in-vitro biological investigations |
| title_full_unstemmed | The exploration of bio-inspired copper oxide nanoparticles: synthesis, characterization and in-vitro biological investigations |
| title_short | The exploration of bio-inspired copper oxide nanoparticles: synthesis, characterization and in-vitro biological investigations |
| title_sort | exploration of bio inspired copper oxide nanoparticles synthesis characterization and in vitro biological investigations |
| topic | Copper oxide nanoparticles Antibacterial Antifungal Cytotoxic activity Ocimum sanctum and Saussurea lappa plant extracts |
| url | http://www.sciencedirect.com/science/article/pii/S2405844022010143 |
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