Relative luminosity in the plus maze upon the exploratory behaviour of female Wistar rats
Objective This study evaluated the provision of two configuration of the Elevated Pluz-Maze (EPM) by analizing the exploratory behaviour of female Wistar rats in different phases of the estrous cycle in EPMs with different gradients of luminosity between the open and enclosed arms (O/E∆Lux).Methods...
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| Format: | Article |
| Language: | English |
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Academia Brasileira de Neurologia (ABNEURO)
2015-07-01
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| Series: | Arquivos de Neuro-Psiquiatria |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2015000700601&lng=en&tlng=en |
| _version_ | 1819131802920419328 |
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| author | Diana Yae Sakae Thiago Mamoru Sakae Marta Aparecida Paschoalini Moacir Serralvo Faria |
| author_facet | Diana Yae Sakae Thiago Mamoru Sakae Marta Aparecida Paschoalini Moacir Serralvo Faria |
| author_sort | Diana Yae Sakae |
| collection | DOAJ |
| description | Objective This study evaluated the provision of two configuration of the Elevated Pluz-Maze (EPM) by analizing the exploratory behaviour of female Wistar rats in different phases of the estrous cycle in EPMs with different gradients of luminosity between the open and enclosed arms (O/E∆Lux).Methods Female Wistar rats were treated with Midazolam (MDZ, 1.0 mg.kg-1) and were tested for their exploratory behaviour in either the EPM 10 O/E∆Lux or EPM 96 O/E∆Lux.Results A multiple regression analysis indicated that the O/E∆Lux is negatively associated with the %Open arm entries and %Open arm time, suggesting that as O/E∆Lux increases, the open arm exploration decreases. The estrous cycle phase did not influence the open-arm exploration in either EPM. MDZ- induced anxiolysis was detected in 96 O/E∆Lux EPM in all phases of the EC.Discussion Results of this study suggest the importance of the O/E∆Lux to establish the arm preference in the EPM, and to preserve the predictive validity of the EPM. |
| first_indexed | 2024-12-22T09:21:18Z |
| format | Article |
| id | doaj.art-3c7eb0f961194da689ec8a3c1892c21e |
| institution | Directory Open Access Journal |
| issn | 1678-4227 |
| language | English |
| last_indexed | 2024-12-22T09:21:18Z |
| publishDate | 2015-07-01 |
| publisher | Academia Brasileira de Neurologia (ABNEURO) |
| record_format | Article |
| series | Arquivos de Neuro-Psiquiatria |
| spelling | doaj.art-3c7eb0f961194da689ec8a3c1892c21e2022-12-21T18:31:11ZengAcademia Brasileira de Neurologia (ABNEURO)Arquivos de Neuro-Psiquiatria1678-42272015-07-0173760160610.1590/0004-282X20150088S0004-282X2015000700601Relative luminosity in the plus maze upon the exploratory behaviour of female Wistar ratsDiana Yae SakaeThiago Mamoru SakaeMarta Aparecida PaschoaliniMoacir Serralvo FariaObjective This study evaluated the provision of two configuration of the Elevated Pluz-Maze (EPM) by analizing the exploratory behaviour of female Wistar rats in different phases of the estrous cycle in EPMs with different gradients of luminosity between the open and enclosed arms (O/E∆Lux).Methods Female Wistar rats were treated with Midazolam (MDZ, 1.0 mg.kg-1) and were tested for their exploratory behaviour in either the EPM 10 O/E∆Lux or EPM 96 O/E∆Lux.Results A multiple regression analysis indicated that the O/E∆Lux is negatively associated with the %Open arm entries and %Open arm time, suggesting that as O/E∆Lux increases, the open arm exploration decreases. The estrous cycle phase did not influence the open-arm exploration in either EPM. MDZ- induced anxiolysis was detected in 96 O/E∆Lux EPM in all phases of the EC.Discussion Results of this study suggest the importance of the O/E∆Lux to establish the arm preference in the EPM, and to preserve the predictive validity of the EPM.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2015000700601&lng=en&tlng=enciclo estralratas Wistaransiedademedolabirinto elevado em cruzluminosidade |
| spellingShingle | Diana Yae Sakae Thiago Mamoru Sakae Marta Aparecida Paschoalini Moacir Serralvo Faria Relative luminosity in the plus maze upon the exploratory behaviour of female Wistar rats Arquivos de Neuro-Psiquiatria ciclo estral ratas Wistar ansiedade medo labirinto elevado em cruz luminosidade |
| title | Relative luminosity in the plus maze upon the exploratory behaviour of female Wistar rats |
| title_full | Relative luminosity in the plus maze upon the exploratory behaviour of female Wistar rats |
| title_fullStr | Relative luminosity in the plus maze upon the exploratory behaviour of female Wistar rats |
| title_full_unstemmed | Relative luminosity in the plus maze upon the exploratory behaviour of female Wistar rats |
| title_short | Relative luminosity in the plus maze upon the exploratory behaviour of female Wistar rats |
| title_sort | relative luminosity in the plus maze upon the exploratory behaviour of female wistar rats |
| topic | ciclo estral ratas Wistar ansiedade medo labirinto elevado em cruz luminosidade |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2015000700601&lng=en&tlng=en |
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