The expression pattern, subcellular localization and function of three sterol 14α-demethylases in Aspergillus oryzae

The expression pattern, subcellular localization and function of three sterol 14α-demethylases in Aspergillus oryzae

Sterol 14α-demethylase catalyzes lanosterol hydroxylation, which is one of the key reactions in the biosynthetic pathway of sterols. There is only one sterol 14α-demethylases gene named Erg11 in Saccharomyces cerevisiae genome. In this study, three sterol 14α-demethylases genes named AoErg11A, AoErg...

Full description

Bibliographic Details
Main Authors:	Qi Jin, Ganghua Li, Kunhai Qin, Yitong Shang, Huanhuan Yan, Hongliang Liu, Bin Zeng, Zhihong Hu
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-01-01
Series:	Frontiers in Genetics
Subjects:	Aspergillus oryzae sterol 14α-demethylase ergosterol subcellular localization function
Online Access:	https://www.frontiersin.org/articles/10.3389/fgene.2023.1009746/full

Similar Items

Roles for Structural Biology in the Discovery of Drugs and Agrochemicals Targeting Sterol 14α-Demethylases
by: Brian C. Monk, et al.
Published: (2021-01-01)

<i>Trichophyton indotineae Erg1</i><sup>Ala448Thr</sup> Strain Expressed Constitutively High Levels of Sterol 14-α Demethylase <i>Erg11B</i> mRNA, While Transporter <i>MDR3</i> and <i>Erg11A</i> mRNA Expression Was Induced After Addition of Short Chain Azoles
by: Nadine Berstecher, et al.
Published: (2024-10-01)

Chemical Defence by Sterols in the Freshwater Ciliate <i>Stentor polymorphus</i>
by: Federico Buonanno, et al.
Published: (2022-11-01)

Impact of TR<sub>34</sub>/L98H, TR<sub>46</sub>/Y121F/T289A and TR<sub>53</sub> Alterations in Azole-Resistant <i>Aspergillus fumigatus</i> on Sterol Composition and Modifications after In Vitro Exposure to Itraconazole and Voriconazole
by: Rose-Anne Lavergne, et al.
Published: (2022-01-01)

Impact of Membrane Lipids on UapA and AzgA Transporter Subcellular Localization and Activity in <i>Aspergillus nidulans</i>
by: Mariangela Dionysopoulou, et al.
Published: (2021-06-01)

Unexpected Role of Sterol Synthesis in RNA Stability and Translation in <i>Leishmania</i>
by: Zemfira N. Karamysheva, et al.
Published: (2021-06-01)

Insights into the role of sterol metabolism in antifungal drug resistance: a mini-review
by: Sunita Tanwar, et al.
Published: (2024-10-01)

Characterization and Role of Sterols in <i>Saccharomyces cerevisiae</i> during White Wine Alcoholic Fermentation
by: Giovana Girardi Piva, et al.
Published: (2022-02-01)

PWWP domain-containing protein Crf4-3 specifically modulates fungal azole susceptibility by regulating sterol C-14 demethylase ERG11
by: Pengju Yu, et al.
Published: (2025-01-01)

Fermentation Process of Aspergillus oryzae and Aspergillus niger of Kelp Paste Optimized by Response Surface Methodology
by: Zhihong ZHONG, et al.
Published: (2022-11-01)

A New Genotype of <i>Trichophyton quinckeanum</i> with Point Mutations in <i>Erg11A</i> Encoding Sterol 14-α Demethylase Exhibits Increased Itraconazole Resistance
by: Paula Winter, et al.
Published: (2023-10-01)

Purification and characterization of glutamate decarboxylase from Aspergillus oryzae NSK
by: Lee, Audrey Ying Yeng
Published: (2014)

Ergosterol biosynthesis and drug development for Chagas disease
by: Julio A Urbina
Published: (2009-07-01)

Targeting Leishmania donovani sterol methyltransferase for leads using pharmacophore modeling and computational molecular mechanics studies
by: Patrick O. Sakyi, et al.
Published: (2023-01-01)

Druggable Sterol Metabolizing Enzymes in Infectious Diseases: Cell Targets to Therapeutic Leads
by: W. David Nes, et al.
Published: (2024-02-01)

Sterol Composition Modulates the Response of <i>Saccharomyces cerevisiae</i> to Iron Deficiency
by: Tania Jordá, et al.
Published: (2021-10-01)

Characterization of Nonaflatoxigenic Aspergillus flavus/oryzae Strains Isolated from Korean Traditional Soybean Meju
by: Sang-Cheol Jun, et al.
Published: (2022-11-01)

Correlation Study between Quality and Sensory Characteristics of Kelp Paste by <i>Aspergillus oryzae</i> and <i>Aspergillus niger</i> during Fermentation
by: Zhihong Zhong, et al.
Published: (2023-04-01)

Identification and subcellular localization of proteins that interact with Duck plague virus pUL14 in infected host cells
by: Jieyu Wan, et al.
Published: (2025-01-01)

Research progress on genes and enzymatic characteristics of proteases from Aspergillus oryzae
by: WU Ribang, CHEN Chen, FANG Bowen, ZHOU Qiyang
Published: (2024-04-01)

The Lysine Demethylases KdmA and KdmB Differently Regulate Asexual Development, Stress Response, and Virulence in <i>Aspergillus fumigatus</i>
by: Yong-Ho Choi, et al.
Published: (2022-05-01)

A multi-aspect analysis of two analogous aspergillus spp. belonging to section Flavi: aspergillus flavus and aspergillus oryzae
by: Waleed Bakry Suleiman
Published: (2023-03-01)

Inhibiting <i>Leishmania donovani</i> Sterol Methyltransferase to Identify Lead Compounds Using Molecular Modelling
by: Patrick O. Sakyi, et al.
Published: (2023-02-01)

Alpha Amylase Production by Aspergillus Oryzae Using Solid State Fermentation
by: Suhad Adnan Ahmed
Published: (2011-10-01)

ALPHA-AMYLASE PRODUCTION FROM Aspergillus oryzae M BY SUBMERGED FERMENTATION
by: Suleimenova, et al.
Published: (2016-08-01)

Histone demethylases in autophagy and inflammation
by: Yaoyao Ma, et al.
Published: (2025-01-01)

Sterols and bile acids/
by: Danielsson, Henry, et al.
Published: (1985)

The postbiotic potential of Aspergillus oryzae – a narrative review
by: Yvonne Seidler, et al.
Published: (2024-10-01)

The sterol content of fungi : ii. screening of representative yeasts and molds for sterol content /
by: 380904 Appleton, G. S., et al.

Use of Potato Nitrogen Concentrate in the Production of α-Amylase by Aspergillus oryzae
by: Eric Thaller, et al.
Published: (2007-01-01)

Mitochondrial dysfunction on Leishmania (Leishmania) amazonensis induced by ketoconazole: insights into drug mode of action
by: Débora Cristina de Oliveira Silva Nunes, et al.
Published: (2022-04-01)

The stepwise selection for ketoconazole resistance induces upregulation of C14-demethylase (CYP51) in Leishmania amazonensis
by: Valter Viana Andrade-Neto, et al.
Published: (2012-05-01)

Histone Demethylase Modulation: Epigenetic Strategy to Combat Cancer Progression
by: Rashmi Srivastava, et al.
Published: (2023-05-01)

Oxidation of Isodrimeninol with PCC Yields Drimane Derivatives with Activity against <i>Candida</i> Yeast by Inhibition of Lanosterol 14-Alpha Demethylase
by: Victor Marin, et al.
Published: (2020-07-01)

Improving the Nutritional Profile of Intermediate Wheatgrass by Solid-State Fermentation with <i>Aspergillus oryzae</i> Strains
by: Takehiro Murai, et al.
Published: (2025-01-01)

Complete mitochondrial genome sequence of Aspergillus oryzae RIB 127 and its comparative analysis with related species
by: Sajjad Asaf, et al.
Published: (2017-12-01)

The major sterols from three species of polyporace ace/
by: Kac, D.

Biotransformation of Ursonic Acid by <i>Aspergillus ochraceus</i> and <i>Aspergillus oryzae</i> to Discover Anti-Neuroinflammatory Derivatives
by: Yan-Ni Wu, et al.
Published: (2023-12-01)

Recent Progress in the Screening and Breeding of Aspergillus oryzae for Brewing
by: FAN Mengxue, WANG Luyao, CHEN Weiwei, WANG Xinjie, WANG Yousheng, CHENG Shiwei
Published: (2023-03-01)

New insights into the effects of Aspergillus oryzae administration during the transition period in Bubalus bubalis
by: Sameh A. Abdelnour, et al.
Published: (2025-12-01)