Altered Cerebral Blood Flow in Alzheimer's Disease With Depression
Background: Depression is common in Alzheimer's disease (AD) with an unclear neural mechanism. This study aimed to investigate the underlying cerebral perfusion associated with depression in AD and evaluate its clinical significance.Method: Twenty-one AD patients and 21 healthy controls (HCs) w...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-07-01
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| Series: | Frontiers in Psychiatry |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2021.687739/full |
| _version_ | 1818580949641723904 |
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| author | Runzhi Li Runzhi Li Yanling Zhang Zhizheng Zhuo Yanli Wang Ziyan Jia Mengfan Sun Yuan Zhang Wenyi Li Yunyun Duan Zeshan Yao Haoyi Weng Juan Wei Yaou Liu Jun Xu Jun Xu |
| author_facet | Runzhi Li Runzhi Li Yanling Zhang Zhizheng Zhuo Yanli Wang Ziyan Jia Mengfan Sun Yuan Zhang Wenyi Li Yunyun Duan Zeshan Yao Haoyi Weng Juan Wei Yaou Liu Jun Xu Jun Xu |
| author_sort | Runzhi Li |
| collection | DOAJ |
| description | Background: Depression is common in Alzheimer's disease (AD) with an unclear neural mechanism. This study aimed to investigate the underlying cerebral perfusion associated with depression in AD and evaluate its clinical significance.Method: Twenty-one AD patients and 21 healthy controls (HCs) were enrolled in this study. The depressive symptom was defined according to the Hamilton Depression Rating Scale (HAMD). Nine patients were diagnosed as AD with depression symptoms (HAMD >7). Three-dimensional pseudocontinuous arterial spin labeling MR imaging was conducted to measure regional cerebral blood flow (CBF). Neuropsychological tests covered cognition and depressive scores. Between-group comparisons on clinical variables and regional CBFs, relationship between regional CBF and depressive score, and identification of AD patients with depression were performed using covariance analysis, linear regression, and receiver operating characteristic (ROC) analysis, respectively.Results: Compared with HCs, AD patients without depression exhibited lower gray matter CBF (p = 0.016); compared with AD patients without depression, AD patients with depression had higher CBF in the right supplementary motor area (39.23 vs. 47.91 ml/100 g/min, p = 0.017) and right supramarginal gyrus (35.54 vs. 43.85 ml/100 g/min, p = 0.034). CBF in the right supplementary motor area was correlated with depressive score (β = 0.46, p = 0.025). The combination of CBF in the right supplementary motor area and supramarginal gyrus and age could identify AD patients with depression from those without depression with a specificity of 100%, sensitivity of 66.67%, accuracy of 85.71%, and area under the curve of 0.87.Conclusions: Our findings suggested that hyperperfusion of the right supplementary motor area and right supramarginal gyrus were associated with depression syndrome in AD, which could provide a potential neuroimaging marker to evaluate the depression state in AD. |
| first_indexed | 2024-12-16T07:25:43Z |
| format | Article |
| id | doaj.art-3c7f2e42e9f24fd08c2213258e59b169 |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-12-16T07:25:43Z |
| publishDate | 2021-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-3c7f2e42e9f24fd08c2213258e59b1692022-12-21T22:39:31ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402021-07-011210.3389/fpsyt.2021.687739687739Altered Cerebral Blood Flow in Alzheimer's Disease With DepressionRunzhi Li0Runzhi Li1Yanling Zhang2Zhizheng Zhuo3Yanli Wang4Ziyan Jia5Mengfan Sun6Yuan Zhang7Wenyi Li8Yunyun Duan9Zeshan Yao10Haoyi Weng11Juan Wei12Yaou Liu13Jun Xu14Jun Xu15Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaDepartment of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaDepartment of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaDepartment of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaDepartment of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaAnImage Technology (Beijing) Co., Ltd., Beijing, ChinaBioinformatics Department, Shenzhen WeGene Clinical Laboratory, Shenzhen, ChinaGE Healthcare, MR Research China, Beijing, ChinaDepartment of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaDepartment of Cognitive Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaBackground: Depression is common in Alzheimer's disease (AD) with an unclear neural mechanism. This study aimed to investigate the underlying cerebral perfusion associated with depression in AD and evaluate its clinical significance.Method: Twenty-one AD patients and 21 healthy controls (HCs) were enrolled in this study. The depressive symptom was defined according to the Hamilton Depression Rating Scale (HAMD). Nine patients were diagnosed as AD with depression symptoms (HAMD >7). Three-dimensional pseudocontinuous arterial spin labeling MR imaging was conducted to measure regional cerebral blood flow (CBF). Neuropsychological tests covered cognition and depressive scores. Between-group comparisons on clinical variables and regional CBFs, relationship between regional CBF and depressive score, and identification of AD patients with depression were performed using covariance analysis, linear regression, and receiver operating characteristic (ROC) analysis, respectively.Results: Compared with HCs, AD patients without depression exhibited lower gray matter CBF (p = 0.016); compared with AD patients without depression, AD patients with depression had higher CBF in the right supplementary motor area (39.23 vs. 47.91 ml/100 g/min, p = 0.017) and right supramarginal gyrus (35.54 vs. 43.85 ml/100 g/min, p = 0.034). CBF in the right supplementary motor area was correlated with depressive score (β = 0.46, p = 0.025). The combination of CBF in the right supplementary motor area and supramarginal gyrus and age could identify AD patients with depression from those without depression with a specificity of 100%, sensitivity of 66.67%, accuracy of 85.71%, and area under the curve of 0.87.Conclusions: Our findings suggested that hyperperfusion of the right supplementary motor area and right supramarginal gyrus were associated with depression syndrome in AD, which could provide a potential neuroimaging marker to evaluate the depression state in AD.https://www.frontiersin.org/articles/10.3389/fpsyt.2021.687739/fullcerebral blood blowAlzheimer's diseasedepressive symptomarterial spin labelneuroimaging marker |
| spellingShingle | Runzhi Li Runzhi Li Yanling Zhang Zhizheng Zhuo Yanli Wang Ziyan Jia Mengfan Sun Yuan Zhang Wenyi Li Yunyun Duan Zeshan Yao Haoyi Weng Juan Wei Yaou Liu Jun Xu Jun Xu Altered Cerebral Blood Flow in Alzheimer's Disease With Depression Frontiers in Psychiatry cerebral blood blow Alzheimer's disease depressive symptom arterial spin label neuroimaging marker |
| title | Altered Cerebral Blood Flow in Alzheimer's Disease With Depression |
| title_full | Altered Cerebral Blood Flow in Alzheimer's Disease With Depression |
| title_fullStr | Altered Cerebral Blood Flow in Alzheimer's Disease With Depression |
| title_full_unstemmed | Altered Cerebral Blood Flow in Alzheimer's Disease With Depression |
| title_short | Altered Cerebral Blood Flow in Alzheimer's Disease With Depression |
| title_sort | altered cerebral blood flow in alzheimer s disease with depression |
| topic | cerebral blood blow Alzheimer's disease depressive symptom arterial spin label neuroimaging marker |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2021.687739/full |
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