Characterizing piggyBat—a transposase for genetic modification of T cells

Characterizing piggyBat—a transposase for genetic modification of T cells

Chimeric antigen receptor (CAR) T cells targeting CD19 have demonstrated remarkable efficacy in the treatment of B cell malignancies. Current CAR T cell manufacturing protocols are complex and costly due to their reliance on viral vectors. Non-viral systems of genetic modification, such as with tran...

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Bibliographic Details
Main Authors: Gaurav Sutrave, Ning Xu, Tiffany C.Y. Tang, Alla Dolnikov, Brian Gloss, David J. Gottlieb, Kenneth P. Micklethwaite, Kavitha Gowrishankar
Format: Article
Language:English
Published: Elsevier 2022-06-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
chimeric antigen receptor
CAR
transposons
non-viral vector
piggybat
T cell immunotherapy
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050122000420

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