A review on controlled porosity osmotic pump tablets and its evaluation
Conventional drug delivery system provides an immediate release of drug which does not control the release of the drug and does not maintain effective concentration at target site for a longer period of time. Hence to avoid the shortcomings there is development of various controlled drug delivery sy...
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| Format: | Article |
| Language: | English |
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Faculty of Pharmacy, Cairo University
2015-12-01
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| Series: | Bulletin of Faculty of Pharmacy Cairo University |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1110093115000319 |
| _version_ | 1797966955557158912 |
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| author | Chinmaya Keshari Sahoo Nalini Kanta Sahoo Surepalli Ram Mohan Rao Muvvala Sudhakar Kokkula Satyanarayana |
| author_facet | Chinmaya Keshari Sahoo Nalini Kanta Sahoo Surepalli Ram Mohan Rao Muvvala Sudhakar Kokkula Satyanarayana |
| author_sort | Chinmaya Keshari Sahoo |
| collection | DOAJ |
| description | Conventional drug delivery system provides an immediate release of drug which does not control the release of the drug and does not maintain effective concentration at target site for a longer period of time. Hence to avoid the shortcomings there is development of various controlled drug delivery systems. Among these osmotic drug delivery system (ODDS) utilizes the principle of osmotic pressure and delivers drug dose in an optimized manner to maintain drug concentration within the therapeutic window and minimizes toxic effects. ODDS releases drug at a controlled rate that is independent of the pH and thermodynamics of dissolution medium. The release of drug from ODDS follows zero order kinetics. The release of drug from osmotic system depends upon various formulation factors such as solubility, osmotic pressure of the core components, size of the delivery orifice and nature of the rate controlling membrane. Controlled porosity osmotic pump (CPOP) contains drug, osmogens, excipients in core and a coating of semipermeable membrane with water soluble additives. In CPOP water soluble additives dissolve after coming in contact with water, resulting in an in situ formation of a microporous membrane. The present study gives an idea about osmosis, CPOP, components of CPOP and its evaluation. |
| first_indexed | 2024-04-11T02:22:29Z |
| format | Article |
| id | doaj.art-3c8225adc0af41a5b75268cc60f062ab |
| institution | Directory Open Access Journal |
| issn | 1110-0931 |
| language | English |
| last_indexed | 2024-04-11T02:22:29Z |
| publishDate | 2015-12-01 |
| publisher | Faculty of Pharmacy, Cairo University |
| record_format | Article |
| series | Bulletin of Faculty of Pharmacy Cairo University |
| spelling | doaj.art-3c8225adc0af41a5b75268cc60f062ab2023-01-02T23:13:51ZengFaculty of Pharmacy, Cairo UniversityBulletin of Faculty of Pharmacy Cairo University1110-09312015-12-0153219520510.1016/j.bfopcu.2015.10.004A review on controlled porosity osmotic pump tablets and its evaluationChinmaya Keshari Sahoo0Nalini Kanta Sahoo1Surepalli Ram Mohan Rao2Muvvala Sudhakar3Kokkula Satyanarayana4Department of Pharmaceutics, Osmania University College of Technology, Osmania University, Hyderabad, Telangana 500007, IndiaMNR College of Pharmacy, Fasalwadi, Sangareddy, Medak, Telangana 502294, IndiaDept. of Chemical Engineering, Osmania University College of Technology, Hyderabad, Telangana 500007, IndiaDepartment of Pharmaceutics, Malla Reddy College of Pharmacy, Maisammaguda, Secunderabad, Telangana 500014, IndiaDepartment of Pharmacognosy, Princeton College of Pharmacy, Korremula, Ghatkesar, R.R. District, Telangana 500088, IndiaConventional drug delivery system provides an immediate release of drug which does not control the release of the drug and does not maintain effective concentration at target site for a longer period of time. Hence to avoid the shortcomings there is development of various controlled drug delivery systems. Among these osmotic drug delivery system (ODDS) utilizes the principle of osmotic pressure and delivers drug dose in an optimized manner to maintain drug concentration within the therapeutic window and minimizes toxic effects. ODDS releases drug at a controlled rate that is independent of the pH and thermodynamics of dissolution medium. The release of drug from ODDS follows zero order kinetics. The release of drug from osmotic system depends upon various formulation factors such as solubility, osmotic pressure of the core components, size of the delivery orifice and nature of the rate controlling membrane. Controlled porosity osmotic pump (CPOP) contains drug, osmogens, excipients in core and a coating of semipermeable membrane with water soluble additives. In CPOP water soluble additives dissolve after coming in contact with water, resulting in an in situ formation of a microporous membrane. The present study gives an idea about osmosis, CPOP, components of CPOP and its evaluation.http://www.sciencedirect.com/science/article/pii/S1110093115000319Osmotic drug delivery systemOsmosisCPOPMicroporousZero order |
| spellingShingle | Chinmaya Keshari Sahoo Nalini Kanta Sahoo Surepalli Ram Mohan Rao Muvvala Sudhakar Kokkula Satyanarayana A review on controlled porosity osmotic pump tablets and its evaluation Bulletin of Faculty of Pharmacy Cairo University Osmotic drug delivery system Osmosis CPOP Microporous Zero order |
| title | A review on controlled porosity osmotic pump tablets and its evaluation |
| title_full | A review on controlled porosity osmotic pump tablets and its evaluation |
| title_fullStr | A review on controlled porosity osmotic pump tablets and its evaluation |
| title_full_unstemmed | A review on controlled porosity osmotic pump tablets and its evaluation |
| title_short | A review on controlled porosity osmotic pump tablets and its evaluation |
| title_sort | review on controlled porosity osmotic pump tablets and its evaluation |
| topic | Osmotic drug delivery system Osmosis CPOP Microporous Zero order |
| url | http://www.sciencedirect.com/science/article/pii/S1110093115000319 |
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