A predictive score for retinopathy of prematurity by using clinical risk factors and serum insulin-like growth factor-1 levels
AIM: To detect the impact of insulin-like growth factor-1 (IGF-1) and other risk factors for the early prediction of retinopathy of prematurity (ROP) and to establish a scoring system for ROP prediction by using clinical criteria and serum IGF-1 levels. METHODS: The study was conducted with 127 pre...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Press of International Journal of Ophthalmology (IJO PRESS)
2017-11-01
|
| Series: | International Journal of Ophthalmology |
| Subjects: | |
| Online Access: | http://www.ijo.cn/en_publish/2017/11/20171114.pdf |
| _version_ | 1819240804775886848 |
|---|---|
| author | Yeşim Coşkun Ceyhun Dalkan Özge Yabaş Özlem Ünay Demirel Elif Samiye Bayar Sibel Sakarya Tuba Müftüoğlu Dilaver Erşanlı Nerin Bahçeciler İpek Akman |
| author_facet | Yeşim Coşkun Ceyhun Dalkan Özge Yabaş Özlem Ünay Demirel Elif Samiye Bayar Sibel Sakarya Tuba Müftüoğlu Dilaver Erşanlı Nerin Bahçeciler İpek Akman |
| author_sort | Yeşim Coşkun |
| collection | DOAJ |
| description | AIM: To detect the impact of insulin-like growth factor-1 (IGF-1) and other risk factors for the early prediction of retinopathy of prematurity (ROP) and to establish a scoring system for ROP prediction by using clinical criteria and serum IGF-1 levels.
METHODS: The study was conducted with 127 preterm infants. IGF-1 levels in the 1st day of life, 1st, 2nd, 3rd and 4th week of life was analyzed. The score was established after logistic regression analysis, considering the impact of each variable on the occurrences of any stage ROP. A validation cohort containing 107 preterm infants was included in the study and the predictive ability of ROP score was calculated.
RESULTS: Birth weights (BW), gestational weeks (GW) and the prevalence of breast milk consumption were lower, respiratory distress syndrome (RDS), bronchopulmonary dysplasia (BPD) and necrotizing enterocolitis (NEC) were more frequent, the duration of mechanical ventilation and oxygen supplementation was longer in patients with ROP (P<0.05). Initial serum IGF-1 levels tended to be lower in newborns who developed ROP. Logistic regression analysis revealed that low BW (<1250 g), presence of intraventricular hemorrhage (IVH) and formula feeding increased the risk of ROP. Afterwards, the scoring system was validated on 107 infants. The negative predictive values of a score less than 4 were 84.3%, 74.7% and 79.8% while positive predictive values were 76.3%, 65.5% and 71.6% respectively.
CONCLUSION: In addition to BW <1250 g and IVH, formula consumption was detected as a risk factor for the development of ROP. Breastfeeding is important for prevention of ROP in preterm infants. |
| first_indexed | 2024-12-23T14:13:50Z |
| format | Article |
| id | doaj.art-3c87a216ebf7403f867249de86b676c1 |
| institution | Directory Open Access Journal |
| issn | 2222-3959 2227-4898 |
| language | English |
| last_indexed | 2024-12-23T14:13:50Z |
| publishDate | 2017-11-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | International Journal of Ophthalmology |
| spelling | doaj.art-3c87a216ebf7403f867249de86b676c12022-12-21T17:43:59ZengPress of International Journal of Ophthalmology (IJO PRESS)International Journal of Ophthalmology2222-39592227-48982017-11-0110111722172710.18240/ijo.2017.11.14A predictive score for retinopathy of prematurity by using clinical risk factors and serum insulin-like growth factor-1 levelsYeşim Coşkun0Ceyhun Dalkan1Özge Yabaş2Özlem Ünay Demirel3Elif Samiye Bayar4Sibel Sakarya5Tuba Müftüoğlu6Dilaver Erşanlı7Nerin Bahçeciler8İpek Akman9Department of Pediatrics, Bahceşehir University Medical Faculty, Medical Park Goztepe Hospital, Istanbul 34732, TurkeyDepartment of Pediatrics, Division of Neonatology, Near East University, Nicosia 99138, North CyprusDepartment of Ophtalmotology, Bahceşehir University Medical Faculty, Medical Park Goztepe Hospital, Istanbul 34732, TurkeyDepartment of Biochemistry, Bahceşehir University Medical Faculty, Medical Park Goztepe Hospital, Istanbul 34732, TurkeyDepartment of Public Health, Marmara University Medical Faculty, Istanbul 34890, TurkeyDepartment of Public Health, Marmara University Medical Faculty, Istanbul 34890, TurkeyDepartment of Biochemistry, GATA Haydarpaşa Hospital, Istanbul 34668, TurkeyDepartment of Ophtalmotology, GATA Haydarpaşa Hospital, Istanbul 34668, TurkeyDepartment of Pediatrics, Near East University, Nicosia 99138, North CyprusDepartment of Pediatrics, Bahceşehir University Medical Faculty, Medical Park Goztepe Hospital, Istanbul 34732, Turkey; Department of Pediatrics, Division of Neonatology, Near East University, Nicosia 99138, North CyprusAIM: To detect the impact of insulin-like growth factor-1 (IGF-1) and other risk factors for the early prediction of retinopathy of prematurity (ROP) and to establish a scoring system for ROP prediction by using clinical criteria and serum IGF-1 levels. METHODS: The study was conducted with 127 preterm infants. IGF-1 levels in the 1st day of life, 1st, 2nd, 3rd and 4th week of life was analyzed. The score was established after logistic regression analysis, considering the impact of each variable on the occurrences of any stage ROP. A validation cohort containing 107 preterm infants was included in the study and the predictive ability of ROP score was calculated. RESULTS: Birth weights (BW), gestational weeks (GW) and the prevalence of breast milk consumption were lower, respiratory distress syndrome (RDS), bronchopulmonary dysplasia (BPD) and necrotizing enterocolitis (NEC) were more frequent, the duration of mechanical ventilation and oxygen supplementation was longer in patients with ROP (P<0.05). Initial serum IGF-1 levels tended to be lower in newborns who developed ROP. Logistic regression analysis revealed that low BW (<1250 g), presence of intraventricular hemorrhage (IVH) and formula feeding increased the risk of ROP. Afterwards, the scoring system was validated on 107 infants. The negative predictive values of a score less than 4 were 84.3%, 74.7% and 79.8% while positive predictive values were 76.3%, 65.5% and 71.6% respectively. CONCLUSION: In addition to BW <1250 g and IVH, formula consumption was detected as a risk factor for the development of ROP. Breastfeeding is important for prevention of ROP in preterm infants.http://www.ijo.cn/en_publish/2017/11/20171114.pdf1727retinopaty of prematurityinsulin-like growth factor-1breast milkprotectivity |
| spellingShingle | Yeşim Coşkun Ceyhun Dalkan Özge Yabaş Özlem Ünay Demirel Elif Samiye Bayar Sibel Sakarya Tuba Müftüoğlu Dilaver Erşanlı Nerin Bahçeciler İpek Akman A predictive score for retinopathy of prematurity by using clinical risk factors and serum insulin-like growth factor-1 levels International Journal of Ophthalmology 1727 retinopaty of prematurity insulin-like growth factor-1 breast milk protectivity |
| title | A predictive score for retinopathy of prematurity by using clinical risk factors and serum insulin-like growth factor-1 levels |
| title_full | A predictive score for retinopathy of prematurity by using clinical risk factors and serum insulin-like growth factor-1 levels |
| title_fullStr | A predictive score for retinopathy of prematurity by using clinical risk factors and serum insulin-like growth factor-1 levels |
| title_full_unstemmed | A predictive score for retinopathy of prematurity by using clinical risk factors and serum insulin-like growth factor-1 levels |
| title_short | A predictive score for retinopathy of prematurity by using clinical risk factors and serum insulin-like growth factor-1 levels |
| title_sort | predictive score for retinopathy of prematurity by using clinical risk factors and serum insulin like growth factor 1 levels |
| topic | 1727 retinopaty of prematurity insulin-like growth factor-1 breast milk protectivity |
| url | http://www.ijo.cn/en_publish/2017/11/20171114.pdf |
| work_keys_str_mv | AT yesimcoskun apredictivescoreforretinopathyofprematuritybyusingclinicalriskfactorsandseruminsulinlikegrowthfactor1levels AT ceyhundalkan apredictivescoreforretinopathyofprematuritybyusingclinicalriskfactorsandseruminsulinlikegrowthfactor1levels AT ozgeyabas apredictivescoreforretinopathyofprematuritybyusingclinicalriskfactorsandseruminsulinlikegrowthfactor1levels AT ozlemunaydemirel apredictivescoreforretinopathyofprematuritybyusingclinicalriskfactorsandseruminsulinlikegrowthfactor1levels AT elifsamiyebayar apredictivescoreforretinopathyofprematuritybyusingclinicalriskfactorsandseruminsulinlikegrowthfactor1levels AT sibelsakarya apredictivescoreforretinopathyofprematuritybyusingclinicalriskfactorsandseruminsulinlikegrowthfactor1levels AT tubamuftuoglu apredictivescoreforretinopathyofprematuritybyusingclinicalriskfactorsandseruminsulinlikegrowthfactor1levels AT dilaverersanlı apredictivescoreforretinopathyofprematuritybyusingclinicalriskfactorsandseruminsulinlikegrowthfactor1levels AT nerinbahceciler apredictivescoreforretinopathyofprematuritybyusingclinicalriskfactorsandseruminsulinlikegrowthfactor1levels AT ipekakman apredictivescoreforretinopathyofprematuritybyusingclinicalriskfactorsandseruminsulinlikegrowthfactor1levels AT yesimcoskun predictivescoreforretinopathyofprematuritybyusingclinicalriskfactorsandseruminsulinlikegrowthfactor1levels AT ceyhundalkan predictivescoreforretinopathyofprematuritybyusingclinicalriskfactorsandseruminsulinlikegrowthfactor1levels AT ozgeyabas predictivescoreforretinopathyofprematuritybyusingclinicalriskfactorsandseruminsulinlikegrowthfactor1levels AT ozlemunaydemirel predictivescoreforretinopathyofprematuritybyusingclinicalriskfactorsandseruminsulinlikegrowthfactor1levels AT elifsamiyebayar predictivescoreforretinopathyofprematuritybyusingclinicalriskfactorsandseruminsulinlikegrowthfactor1levels AT sibelsakarya predictivescoreforretinopathyofprematuritybyusingclinicalriskfactorsandseruminsulinlikegrowthfactor1levels AT tubamuftuoglu predictivescoreforretinopathyofprematuritybyusingclinicalriskfactorsandseruminsulinlikegrowthfactor1levels AT dilaverersanlı predictivescoreforretinopathyofprematuritybyusingclinicalriskfactorsandseruminsulinlikegrowthfactor1levels AT nerinbahceciler predictivescoreforretinopathyofprematuritybyusingclinicalriskfactorsandseruminsulinlikegrowthfactor1levels AT ipekakman predictivescoreforretinopathyofprematuritybyusingclinicalriskfactorsandseruminsulinlikegrowthfactor1levels |