Long noncoding RNAs (lncRNAs) in human lymphomas
Lymphomas are a diverse group of haematologic malignancies, which occur in infection-fighting cells of the lymphatic system. Long non-coding RNAs (lncRNAs) are non-coding RNAs, which have recently received significant attention as the main mediators of gene expression. In this review, we summarize t...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2022-07-01
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| Series: | Genes and Diseases |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352304221000167 |
| _version_ | 1797756625109385216 |
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| author | Ali Gholami Khosro Farhadi Fatemeh Sayyadipour Masoud Soleimani Fakhredin Saba |
| author_facet | Ali Gholami Khosro Farhadi Fatemeh Sayyadipour Masoud Soleimani Fakhredin Saba |
| author_sort | Ali Gholami |
| collection | DOAJ |
| description | Lymphomas are a diverse group of haematologic malignancies, which occur in infection-fighting cells of the lymphatic system. Long non-coding RNAs (lncRNAs) are non-coding RNAs, which have recently received significant attention as the main mediators of gene expression. In this review, we summarize the current knowledge on lncRNAs involved in lymphomas, their molecular functions, as well as their potential clinical value. Relevant literature was identified by a PubMed search of English language papers using the following terms: Lymphoma, LncRNA, leukemia, proliferation, apoptosis, and prognosis. LncRNAs are imperative for lymphoma carcinogenesis through affecting apoptosis, cell proliferation, invasion, and response to chemotherapy. The expression level of lncRNAs can affect chemotherapy-induced apoptosis. Taken together, lncRNA dysregulation in lymphoma cells is not only an epiphenomenon but also lncRNA transcription is critically related to the initiation and progression of lymphomas. Aberrant expression of lncRNAs can lead to the transformation of normal lymphocytes into lymphoma cells. |
| first_indexed | 2024-03-12T18:04:15Z |
| format | Article |
| id | doaj.art-3c8b1d41aa2541f8abef9d5d36c61165 |
| institution | Directory Open Access Journal |
| issn | 2352-3042 |
| language | English |
| last_indexed | 2024-03-12T18:04:15Z |
| publishDate | 2022-07-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Genes and Diseases |
| spelling | doaj.art-3c8b1d41aa2541f8abef9d5d36c611652023-08-02T09:32:06ZengKeAi Communications Co., Ltd.Genes and Diseases2352-30422022-07-0194900914Long noncoding RNAs (lncRNAs) in human lymphomasAli Gholami0Khosro Farhadi1Fatemeh Sayyadipour2Masoud Soleimani3Fakhredin Saba4Clinical Research Development Center, Taleghani and Imam Ali Hospital, Kermanshah University of Medical Sciences, Kermanshah 671568-5420, IranClinical Research Development Center, Taleghani and Imam Ali Hospital, Kermanshah University of Medical Sciences, Kermanshah 671568-5420, IranClinical Research Development Center, Taleghani and Imam Ali Hospital, Kermanshah University of Medical Sciences, Kermanshah 671568-5420, IranDepartment of Haematology, Tarbiat Modares University, Tehran 146899-5513, IranDepartment of Medical Laboratory Science, School of Paramedical, Kermanshah University of Medical Sciences, Kermanshah 671568-5420, Iran; Corresponding author.Lymphomas are a diverse group of haematologic malignancies, which occur in infection-fighting cells of the lymphatic system. Long non-coding RNAs (lncRNAs) are non-coding RNAs, which have recently received significant attention as the main mediators of gene expression. In this review, we summarize the current knowledge on lncRNAs involved in lymphomas, their molecular functions, as well as their potential clinical value. Relevant literature was identified by a PubMed search of English language papers using the following terms: Lymphoma, LncRNA, leukemia, proliferation, apoptosis, and prognosis. LncRNAs are imperative for lymphoma carcinogenesis through affecting apoptosis, cell proliferation, invasion, and response to chemotherapy. The expression level of lncRNAs can affect chemotherapy-induced apoptosis. Taken together, lncRNA dysregulation in lymphoma cells is not only an epiphenomenon but also lncRNA transcription is critically related to the initiation and progression of lymphomas. Aberrant expression of lncRNAs can lead to the transformation of normal lymphocytes into lymphoma cells.http://www.sciencedirect.com/science/article/pii/S2352304221000167ApoptosisLong non-coding RNALymphomaPrognosisProliferation |
| spellingShingle | Ali Gholami Khosro Farhadi Fatemeh Sayyadipour Masoud Soleimani Fakhredin Saba Long noncoding RNAs (lncRNAs) in human lymphomas Genes and Diseases Apoptosis Long non-coding RNA Lymphoma Prognosis Proliferation |
| title | Long noncoding RNAs (lncRNAs) in human lymphomas |
| title_full | Long noncoding RNAs (lncRNAs) in human lymphomas |
| title_fullStr | Long noncoding RNAs (lncRNAs) in human lymphomas |
| title_full_unstemmed | Long noncoding RNAs (lncRNAs) in human lymphomas |
| title_short | Long noncoding RNAs (lncRNAs) in human lymphomas |
| title_sort | long noncoding rnas lncrnas in human lymphomas |
| topic | Apoptosis Long non-coding RNA Lymphoma Prognosis Proliferation |
| url | http://www.sciencedirect.com/science/article/pii/S2352304221000167 |
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