Evidence of gene conversion in genes encoding the Gal/GalNac lectin complex of Entamoeba.
The human gut parasite Entamoeba histolytica, uses a lectin complex on its cell surface to bind to mucin and to ligands on the intestinal epithelia. Binding to mucin is necessary for colonisation and binding to intestinal epithelia for invasion, therefore blocking this binding may protect against am...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2011-06-01
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| Series: | PLoS Neglected Tropical Diseases |
| Online Access: | http://europepmc.org/articles/PMC3125142?pdf=render |
| _version_ | 1811299139598680064 |
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| author | Gareth D Weedall James Sherrington Steve Paterson Neil Hall |
| author_facet | Gareth D Weedall James Sherrington Steve Paterson Neil Hall |
| author_sort | Gareth D Weedall |
| collection | DOAJ |
| description | The human gut parasite Entamoeba histolytica, uses a lectin complex on its cell surface to bind to mucin and to ligands on the intestinal epithelia. Binding to mucin is necessary for colonisation and binding to intestinal epithelia for invasion, therefore blocking this binding may protect against amoebiasis. Acquired protective immunity raised against the lectin complex should create a selection pressure to change the amino acid sequence of lectin genes in order to avoid future detection. We present evidence that gene conversion has occurred in lineages leading to E. histolytica strain HM1:IMSS and E. dispar strain SAW760. This evolutionary mechanism generates diversity and could contribute to immune evasion by the parasites. |
| first_indexed | 2024-04-13T06:30:49Z |
| format | Article |
| id | doaj.art-3c8b6674d95a429a80ecc5c125a12f19 |
| institution | Directory Open Access Journal |
| issn | 1935-2727 1935-2735 |
| language | English |
| last_indexed | 2024-04-13T06:30:49Z |
| publishDate | 2011-06-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Neglected Tropical Diseases |
| spelling | doaj.art-3c8b6674d95a429a80ecc5c125a12f192022-12-22T02:58:08ZengPublic Library of Science (PLoS)PLoS Neglected Tropical Diseases1935-27271935-27352011-06-0156e120910.1371/journal.pntd.0001209Evidence of gene conversion in genes encoding the Gal/GalNac lectin complex of Entamoeba.Gareth D WeedallJames SherringtonSteve PatersonNeil HallThe human gut parasite Entamoeba histolytica, uses a lectin complex on its cell surface to bind to mucin and to ligands on the intestinal epithelia. Binding to mucin is necessary for colonisation and binding to intestinal epithelia for invasion, therefore blocking this binding may protect against amoebiasis. Acquired protective immunity raised against the lectin complex should create a selection pressure to change the amino acid sequence of lectin genes in order to avoid future detection. We present evidence that gene conversion has occurred in lineages leading to E. histolytica strain HM1:IMSS and E. dispar strain SAW760. This evolutionary mechanism generates diversity and could contribute to immune evasion by the parasites.http://europepmc.org/articles/PMC3125142?pdf=render |
| spellingShingle | Gareth D Weedall James Sherrington Steve Paterson Neil Hall Evidence of gene conversion in genes encoding the Gal/GalNac lectin complex of Entamoeba. PLoS Neglected Tropical Diseases |
| title | Evidence of gene conversion in genes encoding the Gal/GalNac lectin complex of Entamoeba. |
| title_full | Evidence of gene conversion in genes encoding the Gal/GalNac lectin complex of Entamoeba. |
| title_fullStr | Evidence of gene conversion in genes encoding the Gal/GalNac lectin complex of Entamoeba. |
| title_full_unstemmed | Evidence of gene conversion in genes encoding the Gal/GalNac lectin complex of Entamoeba. |
| title_short | Evidence of gene conversion in genes encoding the Gal/GalNac lectin complex of Entamoeba. |
| title_sort | evidence of gene conversion in genes encoding the gal galnac lectin complex of entamoeba |
| url | http://europepmc.org/articles/PMC3125142?pdf=render |
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