Sex-Specific Association of Serum Anti-Oxidative Capacity and Leukocyte Telomere Length
Telomeres are a crucial factor in the preservation of genomic integrity, and an elevated risk for diseases such as cancer and cardiovascular events is related to shortened telomeres. However, telomere deterioration could be caused by factors such as chronic oxidative stress and inflammation, which a...
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MDPI AG
2021-11-01
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| 丛编: | Antioxidants |
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| 在线阅读: | https://www.mdpi.com/2076-3921/10/12/1908 |
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| author | Eva Hassler Gunter Almer Gernot Reishofer Gunther Marsche Harald Mangge Hannes Deutschmann Markus Herrmann Stefan Leber Felix Gunzer Wilfried Renner |
| author_facet | Eva Hassler Gunter Almer Gernot Reishofer Gunther Marsche Harald Mangge Hannes Deutschmann Markus Herrmann Stefan Leber Felix Gunzer Wilfried Renner |
| author_sort | Eva Hassler |
| collection | DOAJ |
| description | Telomeres are a crucial factor in the preservation of genomic integrity, and an elevated risk for diseases such as cancer and cardiovascular events is related to shortened telomeres. However, telomere deterioration could be caused by factors such as chronic oxidative stress and inflammation, which are promoted by an imbalance among reactive oxygen species (ROS) and antioxidants. In this cross-sectional study, we investigated the relationship between telomeres and oxidative stress. The serum leucocyte telomer length (LTL), serum total antioxidant capacity (TAC) and the total serum lipid panel of 180 healthy athletic volunteers (90 males, 90 females) were measured Additionally, a questionnaire about sports behaviour and the type of training was completed. We observed a positive significant relation between serum LTL and TAC in the male group (cc = 3.4/<i>p</i> = 0.001) but not in females. There was no statistically significant correlation between age and physical activity and LTL in both groups. This is the first cross sectional study demonstrating an association between total serum TAC and LTL in healthy males, but interestingly, not in the females. Nevertheless, these results should be interpreted as preliminary, and further studies in independent cohorts are needed to investigate the sex-specific effects of oxidative stress on telomere length and telomerase activity. |
| first_indexed | 2024-03-10T04:38:25Z |
| format | Article |
| id | doaj.art-3c8c8e424b7b45c8ac84e2c7e0aa0b82 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-10T04:38:25Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-3c8c8e424b7b45c8ac84e2c7e0aa0b822023-11-23T03:32:46ZengMDPI AGAntioxidants2076-39212021-11-011012190810.3390/antiox10121908Sex-Specific Association of Serum Anti-Oxidative Capacity and Leukocyte Telomere LengthEva Hassler0Gunter Almer1Gernot Reishofer2Gunther Marsche3Harald Mangge4Hannes Deutschmann5Markus Herrmann6Stefan Leber7Felix Gunzer8Wilfried Renner9Division of Neuroradiology, Vascular and Interventional Radiology, Department of Radiology, Medical University Graz, 8036 Graz, AustriaClinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University Graz, 8036 Graz, AustriaDepartment of Radiology, Medical University Graz, 8036 Graz, AustriaDivision of Pharmacology, Otto Loewi Research Center, Medical University of Graz, 8036 Graz, AustriaClinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University Graz, 8036 Graz, AustriaDivision of Neuroradiology, Vascular and Interventional Radiology, Department of Radiology, Medical University Graz, 8036 Graz, AustriaClinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University Graz, 8036 Graz, AustriaDivision of Neuroradiology, Vascular and Interventional Radiology, Department of Radiology, Medical University Graz, 8036 Graz, AustriaDivision of Neuroradiology, Vascular and Interventional Radiology, Department of Radiology, Medical University Graz, 8036 Graz, AustriaClinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University Graz, 8036 Graz, AustriaTelomeres are a crucial factor in the preservation of genomic integrity, and an elevated risk for diseases such as cancer and cardiovascular events is related to shortened telomeres. However, telomere deterioration could be caused by factors such as chronic oxidative stress and inflammation, which are promoted by an imbalance among reactive oxygen species (ROS) and antioxidants. In this cross-sectional study, we investigated the relationship between telomeres and oxidative stress. The serum leucocyte telomer length (LTL), serum total antioxidant capacity (TAC) and the total serum lipid panel of 180 healthy athletic volunteers (90 males, 90 females) were measured Additionally, a questionnaire about sports behaviour and the type of training was completed. We observed a positive significant relation between serum LTL and TAC in the male group (cc = 3.4/<i>p</i> = 0.001) but not in females. There was no statistically significant correlation between age and physical activity and LTL in both groups. This is the first cross sectional study demonstrating an association between total serum TAC and LTL in healthy males, but interestingly, not in the females. Nevertheless, these results should be interpreted as preliminary, and further studies in independent cohorts are needed to investigate the sex-specific effects of oxidative stress on telomere length and telomerase activity.https://www.mdpi.com/2076-3921/10/12/1908leucocyte telomere lengthtelomere shorteningoxidative stresstelomerasetotal antioxidative capacitylifestyle changes |
| spellingShingle | Eva Hassler Gunter Almer Gernot Reishofer Gunther Marsche Harald Mangge Hannes Deutschmann Markus Herrmann Stefan Leber Felix Gunzer Wilfried Renner Sex-Specific Association of Serum Anti-Oxidative Capacity and Leukocyte Telomere Length Antioxidants leucocyte telomere length telomere shortening oxidative stress telomerase total antioxidative capacity lifestyle changes |
| title | Sex-Specific Association of Serum Anti-Oxidative Capacity and Leukocyte Telomere Length |
| title_full | Sex-Specific Association of Serum Anti-Oxidative Capacity and Leukocyte Telomere Length |
| title_fullStr | Sex-Specific Association of Serum Anti-Oxidative Capacity and Leukocyte Telomere Length |
| title_full_unstemmed | Sex-Specific Association of Serum Anti-Oxidative Capacity and Leukocyte Telomere Length |
| title_short | Sex-Specific Association of Serum Anti-Oxidative Capacity and Leukocyte Telomere Length |
| title_sort | sex specific association of serum anti oxidative capacity and leukocyte telomere length |
| topic | leucocyte telomere length telomere shortening oxidative stress telomerase total antioxidative capacity lifestyle changes |
| url | https://www.mdpi.com/2076-3921/10/12/1908 |
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