Synthesis and cytotoxicity evaluation of electrospun PVA magnetic nanofibers containing doxorubicin as targeted nanocarrier for drug delivery
<strong>Objective(s): </strong>The purpose of this study was preparation and evaluation of PVA-Fe<sub>3</sub>O<sub>4</sub> nanofibers as nanocarrier of doxorubicin (DOX) by measuring their drug release together with their in vitro cytotoxicity toward cancer cells...
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Iranian Society of Nanomedicine
2017-12-01
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Series: | Nanomedicine Research Journal |
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Online Access: | http://www.nanomedicine-rj.com/article_29596_5a8731b29471f9cefb84dc25682b9eab.pdf |
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author | Tayebeh Shamspur Fariba Fathirad Mitra Ghanbari Saeed Esmaeili Mahani |
author_facet | Tayebeh Shamspur Fariba Fathirad Mitra Ghanbari Saeed Esmaeili Mahani |
author_sort | Tayebeh Shamspur |
collection | DOAJ |
description | <strong>Objective(s): </strong>The purpose of this study was preparation and evaluation of PVA-Fe<sub>3</sub>O<sub>4</sub> nanofibers as nanocarrier of doxorubicin (DOX) by measuring their drug release together with their in vitro cytotoxicity toward cancer cells at different pH values.<br /> <strong>Methods</strong>: Fe<sub>3</sub>O<sub>4</sub> nanoparticles were synthesized by coprecipitation method. The composite nanofibers of polyvinyl alcohol containing nanoparticles and anticancer drug DOX were fabricated by electrospinning method. The nanostructures were characterized by different techniques. The drug release was investigated by UV-Vis spectrophotometer at different pHs and 37.5 ̊C.<br /> <strong>Results</strong>: In vitro drug release experiments show that the doxorubicin release at pH= 6.0 is promisingly more and faster than drug release at pH= 7.4. The fitted equation of release curves corresponds to Peppas model. Also, MTT assays indicate that the MNPs-doxorubicin-loaded nanocarrier has cytotoxicity comparable with free drug.<br /> <strong>Conclusions</strong>: The synthesized nanocarrier was successfully used for the efficient delivery of an anti-cancer drug into the tumor region. The DOX-loaded nanocarrier showed a steady and sustained release profile in vitro up to 72 h. The drug release from nanocarrier was better described using Peppas model. |
first_indexed | 2024-04-12T16:36:26Z |
format | Article |
id | doaj.art-3c8ceb18c5da4111b417c1e627e111af |
institution | Directory Open Access Journal |
issn | 2476-3489 2476-7123 |
language | English |
last_indexed | 2024-04-12T16:36:26Z |
publishDate | 2017-12-01 |
publisher | Iranian Society of Nanomedicine |
record_format | Article |
series | Nanomedicine Research Journal |
spelling | doaj.art-3c8ceb18c5da4111b417c1e627e111af2022-12-22T03:24:57ZengIranian Society of NanomedicineNanomedicine Research Journal2476-34892476-71232017-12-012422422910.22034/nmrj.2017.04.00329596Synthesis and cytotoxicity evaluation of electrospun PVA magnetic nanofibers containing doxorubicin as targeted nanocarrier for drug deliveryTayebeh Shamspur0Fariba Fathirad1Mitra Ghanbari2Saeed Esmaeili Mahani3Department of Chemistry, Shahid Bahonar University of Kerman, Kerman, IranDepartment of Chemistry, Shahid Bahonar University of Kerman, Kerman, IranDepartment of Chemistry, Faculty of Sciences, Shahid Bahonar University of Kerman, Kerman, Iran|Young Research Society, Shahid Bahonar University of Kerman, Kerman, IranDepartment of Biology, Faculty of Science, Shahid Bahonar University of Kerman, Kerman, Iran<strong>Objective(s): </strong>The purpose of this study was preparation and evaluation of PVA-Fe<sub>3</sub>O<sub>4</sub> nanofibers as nanocarrier of doxorubicin (DOX) by measuring their drug release together with their in vitro cytotoxicity toward cancer cells at different pH values.<br /> <strong>Methods</strong>: Fe<sub>3</sub>O<sub>4</sub> nanoparticles were synthesized by coprecipitation method. The composite nanofibers of polyvinyl alcohol containing nanoparticles and anticancer drug DOX were fabricated by electrospinning method. The nanostructures were characterized by different techniques. The drug release was investigated by UV-Vis spectrophotometer at different pHs and 37.5 ̊C.<br /> <strong>Results</strong>: In vitro drug release experiments show that the doxorubicin release at pH= 6.0 is promisingly more and faster than drug release at pH= 7.4. The fitted equation of release curves corresponds to Peppas model. Also, MTT assays indicate that the MNPs-doxorubicin-loaded nanocarrier has cytotoxicity comparable with free drug.<br /> <strong>Conclusions</strong>: The synthesized nanocarrier was successfully used for the efficient delivery of an anti-cancer drug into the tumor region. The DOX-loaded nanocarrier showed a steady and sustained release profile in vitro up to 72 h. The drug release from nanocarrier was better described using Peppas model.http://www.nanomedicine-rj.com/article_29596_5a8731b29471f9cefb84dc25682b9eab.pdfsuperparamagnetic fe3o4 nanoparticlesnanocarriernanofiberdoxorubicindrug delivery |
spellingShingle | Tayebeh Shamspur Fariba Fathirad Mitra Ghanbari Saeed Esmaeili Mahani Synthesis and cytotoxicity evaluation of electrospun PVA magnetic nanofibers containing doxorubicin as targeted nanocarrier for drug delivery Nanomedicine Research Journal superparamagnetic fe3o4 nanoparticles nanocarrier nanofiber doxorubicin drug delivery |
title | Synthesis and cytotoxicity evaluation of electrospun PVA magnetic nanofibers containing doxorubicin as targeted nanocarrier for drug delivery |
title_full | Synthesis and cytotoxicity evaluation of electrospun PVA magnetic nanofibers containing doxorubicin as targeted nanocarrier for drug delivery |
title_fullStr | Synthesis and cytotoxicity evaluation of electrospun PVA magnetic nanofibers containing doxorubicin as targeted nanocarrier for drug delivery |
title_full_unstemmed | Synthesis and cytotoxicity evaluation of electrospun PVA magnetic nanofibers containing doxorubicin as targeted nanocarrier for drug delivery |
title_short | Synthesis and cytotoxicity evaluation of electrospun PVA magnetic nanofibers containing doxorubicin as targeted nanocarrier for drug delivery |
title_sort | synthesis and cytotoxicity evaluation of electrospun pva magnetic nanofibers containing doxorubicin as targeted nanocarrier for drug delivery |
topic | superparamagnetic fe3o4 nanoparticles nanocarrier nanofiber doxorubicin drug delivery |
url | http://www.nanomedicine-rj.com/article_29596_5a8731b29471f9cefb84dc25682b9eab.pdf |
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