Clinical and metabolic characteristics of endometrial lesions in polycystic ovary syndrome at reproductive age
Abstract Background We aimed to explore the clinical and metabolic characteristics in polycystic ovary syndrome (PCOS) patients with different endometrial lesions. Methods 234 PCOS patients who underwent hysteroscopy and endometrial biopsy were categorized into four groups: (1) normal endometrium (c...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2023-05-01
|
| Series: | BMC Women's Health |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12905-023-02339-7 |
| _version_ | 1797831944080195584 |
|---|---|
| author | Xiaozhu Zhong⋅ Yang Li⋅ Weiying Liang Qiyue Hu Anqi Zeng Miao Ding Dongmei Chen Meiqing Xie |
| author_facet | Xiaozhu Zhong⋅ Yang Li⋅ Weiying Liang Qiyue Hu Anqi Zeng Miao Ding Dongmei Chen Meiqing Xie |
| author_sort | Xiaozhu Zhong⋅ |
| collection | DOAJ |
| description | Abstract Background We aimed to explore the clinical and metabolic characteristics in polycystic ovary syndrome (PCOS) patients with different endometrial lesions. Methods 234 PCOS patients who underwent hysteroscopy and endometrial biopsy were categorized into four groups: (1) normal endometrium (control group, n = 98), (2) endometrial polyp (EP group, n = 92), (3) endometrial hyperplasia (EH group, n = 33), (4) endometrial cancer (EC group, n = 11). Serum sex hormone levels, 75 g oral glucose tolerance test, insulin release test, fasting plasma lipid, complete blood count and coagulation parameters were measured and analyzed. Results Body mass index and triglyceride level of the EH group were higher while average menstrual cycle length was longer in comparison with the control and EP group. Sex hormone-binding globulin (SHBG) and high density lipoprotein were lower in the EH group than that in the control group. 36% of the patients in the EH group suggested obesity, higher than the other three groups. Using multivariant regression analysis, patients with free androgen index > 5 had higher risk of EH (OR 5.70; 95% CI 1.05–31.01), while metformin appeared to be a protective factor for EH (OR 0.12; 95% CI 0.02–0.80). Metformin and hormones (oral contraceptives or progestogen) were shown to be protective factors for EP (OR 0.09; 95% CI 0.02–0.42; OR 0.10; 95% CI 0.02–0.56). Hormones therapy appeared to be a protective factor for EC (OR 0.05; 95% CI 0.01–0.39). Conclusion Obesity, prolonged menstrual cycle, decreased SHBG, and dyslipidemia are risk factors for EH in patients with PCOS. Oral contraceptives, progestogen and metformin are recommended for prevention and treatment of endometrial lesions in PCOS patients. |
| first_indexed | 2024-04-09T13:59:47Z |
| format | Article |
| id | doaj.art-3c8d727e6a6543feb3ed1bdc1110efcc |
| institution | Directory Open Access Journal |
| issn | 1472-6874 |
| language | English |
| last_indexed | 2024-04-09T13:59:47Z |
| publishDate | 2023-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Women's Health |
| spelling | doaj.art-3c8d727e6a6543feb3ed1bdc1110efcc2023-05-07T11:22:35ZengBMCBMC Women's Health1472-68742023-05-012311910.1186/s12905-023-02339-7Clinical and metabolic characteristics of endometrial lesions in polycystic ovary syndrome at reproductive ageXiaozhu Zhong⋅0Yang Li⋅1Weiying Liang2Qiyue Hu3Anqi Zeng4Miao Ding5Dongmei Chen6Meiqing Xie7Department of Obstetrics and Gynecology, Sun Yat-sen Memorial Hospital, Sun Yat-sen UniversityDepartment of Obstetrics and Gynecology, Sun Yat-sen Memorial Hospital, Sun Yat-sen UniversityDepartment of Obstetrics and Gynecology, Sun Yat-sen Memorial Hospital, Sun Yat-sen UniversityDepartment of Obstetrics and Gynecology, Sun Yat-sen Memorial Hospital, Sun Yat-sen UniversityDepartment of Obstetrics and Gynecology, Sun Yat-sen Memorial Hospital, Sun Yat-sen UniversityDepartment of Obstetrics and Gynecology, Sun Yat-sen Memorial Hospital, Sun Yat-sen UniversityDepartment of Obstetrics and Gynecology, Sun Yat-sen Memorial Hospital, Sun Yat-sen UniversityDepartment of Obstetrics and Gynecology, Sun Yat-sen Memorial Hospital, Sun Yat-sen UniversityAbstract Background We aimed to explore the clinical and metabolic characteristics in polycystic ovary syndrome (PCOS) patients with different endometrial lesions. Methods 234 PCOS patients who underwent hysteroscopy and endometrial biopsy were categorized into four groups: (1) normal endometrium (control group, n = 98), (2) endometrial polyp (EP group, n = 92), (3) endometrial hyperplasia (EH group, n = 33), (4) endometrial cancer (EC group, n = 11). Serum sex hormone levels, 75 g oral glucose tolerance test, insulin release test, fasting plasma lipid, complete blood count and coagulation parameters were measured and analyzed. Results Body mass index and triglyceride level of the EH group were higher while average menstrual cycle length was longer in comparison with the control and EP group. Sex hormone-binding globulin (SHBG) and high density lipoprotein were lower in the EH group than that in the control group. 36% of the patients in the EH group suggested obesity, higher than the other three groups. Using multivariant regression analysis, patients with free androgen index > 5 had higher risk of EH (OR 5.70; 95% CI 1.05–31.01), while metformin appeared to be a protective factor for EH (OR 0.12; 95% CI 0.02–0.80). Metformin and hormones (oral contraceptives or progestogen) were shown to be protective factors for EP (OR 0.09; 95% CI 0.02–0.42; OR 0.10; 95% CI 0.02–0.56). Hormones therapy appeared to be a protective factor for EC (OR 0.05; 95% CI 0.01–0.39). Conclusion Obesity, prolonged menstrual cycle, decreased SHBG, and dyslipidemia are risk factors for EH in patients with PCOS. Oral contraceptives, progestogen and metformin are recommended for prevention and treatment of endometrial lesions in PCOS patients.https://doi.org/10.1186/s12905-023-02339-7Polycystic ovary syndromeEndometrial lesionsObesityMetforminHormones |
| spellingShingle | Xiaozhu Zhong⋅ Yang Li⋅ Weiying Liang Qiyue Hu Anqi Zeng Miao Ding Dongmei Chen Meiqing Xie Clinical and metabolic characteristics of endometrial lesions in polycystic ovary syndrome at reproductive age BMC Women's Health Polycystic ovary syndrome Endometrial lesions Obesity Metformin Hormones |
| title | Clinical and metabolic characteristics of endometrial lesions in polycystic ovary syndrome at reproductive age |
| title_full | Clinical and metabolic characteristics of endometrial lesions in polycystic ovary syndrome at reproductive age |
| title_fullStr | Clinical and metabolic characteristics of endometrial lesions in polycystic ovary syndrome at reproductive age |
| title_full_unstemmed | Clinical and metabolic characteristics of endometrial lesions in polycystic ovary syndrome at reproductive age |
| title_short | Clinical and metabolic characteristics of endometrial lesions in polycystic ovary syndrome at reproductive age |
| title_sort | clinical and metabolic characteristics of endometrial lesions in polycystic ovary syndrome at reproductive age |
| topic | Polycystic ovary syndrome Endometrial lesions Obesity Metformin Hormones |
| url | https://doi.org/10.1186/s12905-023-02339-7 |
| work_keys_str_mv | AT xiaozhuzhong clinicalandmetaboliccharacteristicsofendometriallesionsinpolycysticovarysyndromeatreproductiveage AT yangli clinicalandmetaboliccharacteristicsofendometriallesionsinpolycysticovarysyndromeatreproductiveage AT weiyingliang clinicalandmetaboliccharacteristicsofendometriallesionsinpolycysticovarysyndromeatreproductiveage AT qiyuehu clinicalandmetaboliccharacteristicsofendometriallesionsinpolycysticovarysyndromeatreproductiveage AT anqizeng clinicalandmetaboliccharacteristicsofendometriallesionsinpolycysticovarysyndromeatreproductiveage AT miaoding clinicalandmetaboliccharacteristicsofendometriallesionsinpolycysticovarysyndromeatreproductiveage AT dongmeichen clinicalandmetaboliccharacteristicsofendometriallesionsinpolycysticovarysyndromeatreproductiveage AT meiqingxie clinicalandmetaboliccharacteristicsofendometriallesionsinpolycysticovarysyndromeatreproductiveage |