Application of Halloysite Nanotubes in Cancer Therapy—A Review
Halloysite, a nanoclay characterized by a unique, tubular structure, with oppositely charged interior and exterior, suitable, nanometric-range size, high biocompatibility, and low cost, is recently gaining more and more interest as an important and versatile component of various biomaterials and del...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-05-01
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| Series: | Materials |
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| Online Access: | https://www.mdpi.com/1996-1944/14/11/2943 |
| _version_ | 1797532045394575360 |
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| author | Anna Karewicz Adrianna Machowska Martyna Kasprzyk Gabriela Ledwójcik |
| author_facet | Anna Karewicz Adrianna Machowska Martyna Kasprzyk Gabriela Ledwójcik |
| author_sort | Anna Karewicz |
| collection | DOAJ |
| description | Halloysite, a nanoclay characterized by a unique, tubular structure, with oppositely charged interior and exterior, suitable, nanometric-range size, high biocompatibility, and low cost, is recently gaining more and more interest as an important and versatile component of various biomaterials and delivery systems of biomedical relevance. One of the most recent, significant, and intensely studied fields in which halloysite nanotubes (HNTs) found diverse applications is cancer therapy. Even though this particular direction is mentioned in several more general reviews, it has never so far been discussed in detail. In our review, we offer an extended survey of the literature on that particular aspect of the biomedical application of HNTs. While historical perspective is also given, our paper is focused on the most recent developments in this field, including controlled delivery and release of anticancer agents and nucleic acids by HNT-based systems, targeting cancer cells using HNT as a carrier, and the capture and analysis of circulating tumor cells (CTCs) with nanostructured or magnetic HNT surfaces. The overview of the most up-to-date knowledge on the HNT interactions with cancer cells is also given. |
| first_indexed | 2024-03-10T10:53:29Z |
| format | Article |
| id | doaj.art-3c8e6dc0ffba494586557b139b5f1601 |
| institution | Directory Open Access Journal |
| issn | 1996-1944 |
| language | English |
| last_indexed | 2024-03-10T10:53:29Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Materials |
| spelling | doaj.art-3c8e6dc0ffba494586557b139b5f16012023-11-21T22:01:29ZengMDPI AGMaterials1996-19442021-05-011411294310.3390/ma14112943Application of Halloysite Nanotubes in Cancer Therapy—A ReviewAnna Karewicz0Adrianna Machowska1Martyna Kasprzyk2Gabriela Ledwójcik3Department of Chemistry, Jagiellonian University in Cracow, Gronostajowa 2, 30-387 Cracow, PolandDepartment of Chemistry, Jagiellonian University in Cracow, Gronostajowa 2, 30-387 Cracow, PolandDepartment of Chemistry, Jagiellonian University in Cracow, Gronostajowa 2, 30-387 Cracow, PolandDepartment of Chemistry, Jagiellonian University in Cracow, Gronostajowa 2, 30-387 Cracow, PolandHalloysite, a nanoclay characterized by a unique, tubular structure, with oppositely charged interior and exterior, suitable, nanometric-range size, high biocompatibility, and low cost, is recently gaining more and more interest as an important and versatile component of various biomaterials and delivery systems of biomedical relevance. One of the most recent, significant, and intensely studied fields in which halloysite nanotubes (HNTs) found diverse applications is cancer therapy. Even though this particular direction is mentioned in several more general reviews, it has never so far been discussed in detail. In our review, we offer an extended survey of the literature on that particular aspect of the biomedical application of HNTs. While historical perspective is also given, our paper is focused on the most recent developments in this field, including controlled delivery and release of anticancer agents and nucleic acids by HNT-based systems, targeting cancer cells using HNT as a carrier, and the capture and analysis of circulating tumor cells (CTCs) with nanostructured or magnetic HNT surfaces. The overview of the most up-to-date knowledge on the HNT interactions with cancer cells is also given.https://www.mdpi.com/1996-1944/14/11/2943halloysite nanotubescancer cellscontrolled releasetargeted deliverynanostructured surfacesmagnetic surfaces |
| spellingShingle | Anna Karewicz Adrianna Machowska Martyna Kasprzyk Gabriela Ledwójcik Application of Halloysite Nanotubes in Cancer Therapy—A Review Materials halloysite nanotubes cancer cells controlled release targeted delivery nanostructured surfaces magnetic surfaces |
| title | Application of Halloysite Nanotubes in Cancer Therapy—A Review |
| title_full | Application of Halloysite Nanotubes in Cancer Therapy—A Review |
| title_fullStr | Application of Halloysite Nanotubes in Cancer Therapy—A Review |
| title_full_unstemmed | Application of Halloysite Nanotubes in Cancer Therapy—A Review |
| title_short | Application of Halloysite Nanotubes in Cancer Therapy—A Review |
| title_sort | application of halloysite nanotubes in cancer therapy a review |
| topic | halloysite nanotubes cancer cells controlled release targeted delivery nanostructured surfaces magnetic surfaces |
| url | https://www.mdpi.com/1996-1944/14/11/2943 |
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