Involvement of inflammatory responses in the brain to the onset of major depressive disorder due to stress exposure
Major depressive disorder (MDD) is a multifactorial disease affected by several environmental factors. Although several potential onset hypotheses have been identified, the molecular mechanisms underlying the pathogenesis of this disorder remain unclear. Several recent studies have suggested that am...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-07-01
|
| Series: | Frontiers in Aging Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2022.934346/full |
| _version_ | 1811288487111950336 |
|---|---|
| author | Shingo Miyata Yugo Ishino Shoko Shimizu Masaya Tohyama Masaya Tohyama |
| author_facet | Shingo Miyata Yugo Ishino Shoko Shimizu Masaya Tohyama Masaya Tohyama |
| author_sort | Shingo Miyata |
| collection | DOAJ |
| description | Major depressive disorder (MDD) is a multifactorial disease affected by several environmental factors. Although several potential onset hypotheses have been identified, the molecular mechanisms underlying the pathogenesis of this disorder remain unclear. Several recent studies have suggested that among many environmental factors, inflammation and immune abnormalities in the brain or the peripheral tissues are associated with the onset of MDDs. Furthermore, several stress-related hypotheses have been proposed to explain the onset of MDDs. Thus, inflammation or immune abnormalities can be considered stress responses that occur within the brain or other tissues and are regarded as one of the mechanisms underlying the stress hypothesis of MDDs. Therefore, we introduce several current advances in inflammation studies in the brain that might be related to the pathophysiology of MDD due to stress exposure in this review. |
| first_indexed | 2024-04-13T03:37:56Z |
| format | Article |
| id | doaj.art-3c8fbd7a7ccb44268426eedc530c43c5 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-04-13T03:37:56Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-3c8fbd7a7ccb44268426eedc530c43c52022-12-22T03:04:17ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652022-07-011410.3389/fnagi.2022.934346934346Involvement of inflammatory responses in the brain to the onset of major depressive disorder due to stress exposureShingo Miyata0Yugo Ishino1Shoko Shimizu2Masaya Tohyama3Masaya Tohyama4Division of Molecular Brain Science, Research Institute of Traditional Asian Medicine, Kindai University, Osaka, JapanDivision of Molecular Brain Science, Research Institute of Traditional Asian Medicine, Kindai University, Osaka, JapanDivision of Molecular Brain Science, Research Institute of Traditional Asian Medicine, Kindai University, Osaka, JapanDivision of Molecular Brain Science, Research Institute of Traditional Asian Medicine, Kindai University, Osaka, JapanOsaka Prefectural Hospital Organization, Osaka, JapanMajor depressive disorder (MDD) is a multifactorial disease affected by several environmental factors. Although several potential onset hypotheses have been identified, the molecular mechanisms underlying the pathogenesis of this disorder remain unclear. Several recent studies have suggested that among many environmental factors, inflammation and immune abnormalities in the brain or the peripheral tissues are associated with the onset of MDDs. Furthermore, several stress-related hypotheses have been proposed to explain the onset of MDDs. Thus, inflammation or immune abnormalities can be considered stress responses that occur within the brain or other tissues and are regarded as one of the mechanisms underlying the stress hypothesis of MDDs. Therefore, we introduce several current advances in inflammation studies in the brain that might be related to the pathophysiology of MDD due to stress exposure in this review.https://www.frontiersin.org/articles/10.3389/fnagi.2022.934346/fullmajor depressive disordersstress hypothesiscGAS-STING pathwayinflammasomeimmunosenescence |
| spellingShingle | Shingo Miyata Yugo Ishino Shoko Shimizu Masaya Tohyama Masaya Tohyama Involvement of inflammatory responses in the brain to the onset of major depressive disorder due to stress exposure Frontiers in Aging Neuroscience major depressive disorders stress hypothesis cGAS-STING pathway inflammasome immunosenescence |
| title | Involvement of inflammatory responses in the brain to the onset of major depressive disorder due to stress exposure |
| title_full | Involvement of inflammatory responses in the brain to the onset of major depressive disorder due to stress exposure |
| title_fullStr | Involvement of inflammatory responses in the brain to the onset of major depressive disorder due to stress exposure |
| title_full_unstemmed | Involvement of inflammatory responses in the brain to the onset of major depressive disorder due to stress exposure |
| title_short | Involvement of inflammatory responses in the brain to the onset of major depressive disorder due to stress exposure |
| title_sort | involvement of inflammatory responses in the brain to the onset of major depressive disorder due to stress exposure |
| topic | major depressive disorders stress hypothesis cGAS-STING pathway inflammasome immunosenescence |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2022.934346/full |
| work_keys_str_mv | AT shingomiyata involvementofinflammatoryresponsesinthebraintotheonsetofmajordepressivedisorderduetostressexposure AT yugoishino involvementofinflammatoryresponsesinthebraintotheonsetofmajordepressivedisorderduetostressexposure AT shokoshimizu involvementofinflammatoryresponsesinthebraintotheonsetofmajordepressivedisorderduetostressexposure AT masayatohyama involvementofinflammatoryresponsesinthebraintotheonsetofmajordepressivedisorderduetostressexposure AT masayatohyama involvementofinflammatoryresponsesinthebraintotheonsetofmajordepressivedisorderduetostressexposure |