Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication
Coronavirus main protease is essential for viral polyprotein processing and replication. Here Vuong et al. report efficient inhibition of SARS-CoV-2 replication by the dipeptide-based protease inhibitor GC376 and its parent GC373, which were originally used to treat feline coronavirus infection.
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2020-08-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-18096-2 |
| _version_ | 1818851557918113792 |
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| author | Wayne Vuong Muhammad Bashir Khan Conrad Fischer Elena Arutyunova Tess Lamer Justin Shields Holly A. Saffran Ryan T. McKay Marco J. van Belkum Michael A. Joyce Howard S. Young D. Lorne Tyrrell John C. Vederas M. Joanne Lemieux |
| author_facet | Wayne Vuong Muhammad Bashir Khan Conrad Fischer Elena Arutyunova Tess Lamer Justin Shields Holly A. Saffran Ryan T. McKay Marco J. van Belkum Michael A. Joyce Howard S. Young D. Lorne Tyrrell John C. Vederas M. Joanne Lemieux |
| author_sort | Wayne Vuong |
| collection | DOAJ |
| description | Coronavirus main protease is essential for viral polyprotein processing and replication. Here Vuong et al. report efficient inhibition of SARS-CoV-2 replication by the dipeptide-based protease inhibitor GC376 and its parent GC373, which were originally used to treat feline coronavirus infection. |
| first_indexed | 2024-12-19T07:06:56Z |
| format | Article |
| id | doaj.art-3c902c5ef40f40398c856f91dffa7d74 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T07:06:56Z |
| publishDate | 2020-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-3c902c5ef40f40398c856f91dffa7d742022-12-21T20:31:15ZengNature PortfolioNature Communications2041-17232020-08-011111810.1038/s41467-020-18096-2Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replicationWayne Vuong0Muhammad Bashir Khan1Conrad Fischer2Elena Arutyunova3Tess Lamer4Justin Shields5Holly A. Saffran6Ryan T. McKay7Marco J. van Belkum8Michael A. Joyce9Howard S. Young10D. Lorne Tyrrell11John C. Vederas12M. Joanne Lemieux13Department of Chemistry, University of AlbertaDepartment of Biochemistry, Membrane Protein Disease Research Group, University of AlbertaDepartment of Chemistry, University of AlbertaDepartment of Biochemistry, Membrane Protein Disease Research Group, University of AlbertaDepartment of Chemistry, University of AlbertaDepartment of Medical Microbiology and Immunology, University of AlbertaDepartment of Medical Microbiology and Immunology, University of AlbertaDepartment of Chemistry, University of AlbertaDepartment of Chemistry, University of AlbertaDepartment of Medical Microbiology and Immunology, University of AlbertaDepartment of Biochemistry, Membrane Protein Disease Research Group, University of AlbertaDepartment of Medical Microbiology and Immunology, University of AlbertaDepartment of Chemistry, University of AlbertaDepartment of Biochemistry, Membrane Protein Disease Research Group, University of AlbertaCoronavirus main protease is essential for viral polyprotein processing and replication. Here Vuong et al. report efficient inhibition of SARS-CoV-2 replication by the dipeptide-based protease inhibitor GC376 and its parent GC373, which were originally used to treat feline coronavirus infection.https://doi.org/10.1038/s41467-020-18096-2 |
| spellingShingle | Wayne Vuong Muhammad Bashir Khan Conrad Fischer Elena Arutyunova Tess Lamer Justin Shields Holly A. Saffran Ryan T. McKay Marco J. van Belkum Michael A. Joyce Howard S. Young D. Lorne Tyrrell John C. Vederas M. Joanne Lemieux Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication Nature Communications |
| title | Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication |
| title_full | Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication |
| title_fullStr | Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication |
| title_full_unstemmed | Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication |
| title_short | Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication |
| title_sort | feline coronavirus drug inhibits the main protease of sars cov 2 and blocks virus replication |
| url | https://doi.org/10.1038/s41467-020-18096-2 |
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