Fluoroquinolone sales in food animals and quinolone resistance in non-typhoidal Salmonella from retail meats: United States, 2009–2018
ABSTRACT: Objectives: Antimicrobial-resistant non-typhoidal Salmonella (NTS) infections are associated with worse health outcomes compared to antimicrobial-susceptible infections. Misuse of antimicrobials in food animals can amplify the emergence of antimicrobial resistance.The objective of this st...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-06-01
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| Series: | Journal of Global Antimicrobial Resistance |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213716522000595 |
| _version_ | 1818230811255635968 |
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| author | Xin Yin Edward G. Dudley Casey N. Pinto Nkuchia M. M'ikanatha |
| author_facet | Xin Yin Edward G. Dudley Casey N. Pinto Nkuchia M. M'ikanatha |
| author_sort | Xin Yin |
| collection | DOAJ |
| description | ABSTRACT: Objectives: Antimicrobial-resistant non-typhoidal Salmonella (NTS) infections are associated with worse health outcomes compared to antimicrobial-susceptible infections. Misuse of antimicrobials in food animals can amplify the emergence of antimicrobial resistance.The objective of this study was to examine the association between fluoroquinolone sales in food animals and the prevalence of quinolone-resistant NTS isolated from retail meats. Methods: We reviewed data for 4318 NTS isolates from retail meat samples collected from 2009 to 2018 through the FDA National Antimicrobial Resistance Monitoring System programs. The Pearson's correlation was used to examine the correlation between the prevalence of quinolone-resistant NTS and standardised fluoroquinolone sales. Results: After adjusting for the increase in beef and pork production, fluoroquinolone sales increased by 41.67% from 2013 to 2018. The prevalence of quinolone-resistant NTS from retail ground beef increased from 5% in 2014 to 11% in 2018. The increase of quinolone-resistant isolates in retail meats since 2016 was mostly related to Salmonella Infantis and Salmonella enteritidis. Conclusion: One Health integrated surveillance for NTS isolates from food of animal origin and human sources is necessary to elucidate trends in resistance to critical drugs. The study also underscores the need for judicious use of antimicrobials in agricultural settings. |
| first_indexed | 2024-12-12T10:40:25Z |
| format | Article |
| id | doaj.art-3c9054dde3bc4333a4d6297fd8871ec5 |
| institution | Directory Open Access Journal |
| issn | 2213-7165 |
| language | English |
| last_indexed | 2024-12-12T10:40:25Z |
| publishDate | 2022-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Global Antimicrobial Resistance |
| spelling | doaj.art-3c9054dde3bc4333a4d6297fd8871ec52022-12-22T00:27:04ZengElsevierJournal of Global Antimicrobial Resistance2213-71652022-06-0129163167Fluoroquinolone sales in food animals and quinolone resistance in non-typhoidal Salmonella from retail meats: United States, 2009–2018Xin Yin0Edward G. Dudley1Casey N. Pinto2Nkuchia M. M'ikanatha3Public Health Sciences Department, Penn State College of Medicine, Hershey, PennsylvaniaDepartment of Food Science, The Pennsylvania State University, University Park, PennsylvaniaPublic Health Sciences Department, Penn State College of Medicine, Hershey, PennsylvaniaPennsylvania Department of Health, Harrisburg, Pennsylvania; Corresponding author. N. M'ikanatha. Mailing address: Pennsylvania Department of Health Health & Welfare Building Harrisburg, PA 17120, United States.ABSTRACT: Objectives: Antimicrobial-resistant non-typhoidal Salmonella (NTS) infections are associated with worse health outcomes compared to antimicrobial-susceptible infections. Misuse of antimicrobials in food animals can amplify the emergence of antimicrobial resistance.The objective of this study was to examine the association between fluoroquinolone sales in food animals and the prevalence of quinolone-resistant NTS isolated from retail meats. Methods: We reviewed data for 4318 NTS isolates from retail meat samples collected from 2009 to 2018 through the FDA National Antimicrobial Resistance Monitoring System programs. The Pearson's correlation was used to examine the correlation between the prevalence of quinolone-resistant NTS and standardised fluoroquinolone sales. Results: After adjusting for the increase in beef and pork production, fluoroquinolone sales increased by 41.67% from 2013 to 2018. The prevalence of quinolone-resistant NTS from retail ground beef increased from 5% in 2014 to 11% in 2018. The increase of quinolone-resistant isolates in retail meats since 2016 was mostly related to Salmonella Infantis and Salmonella enteritidis. Conclusion: One Health integrated surveillance for NTS isolates from food of animal origin and human sources is necessary to elucidate trends in resistance to critical drugs. The study also underscores the need for judicious use of antimicrobials in agricultural settings.http://www.sciencedirect.com/science/article/pii/S2213716522000595Antimicrobial stewardshipAntibiotic resistanceSalmonellaMeat |
| spellingShingle | Xin Yin Edward G. Dudley Casey N. Pinto Nkuchia M. M'ikanatha Fluoroquinolone sales in food animals and quinolone resistance in non-typhoidal Salmonella from retail meats: United States, 2009–2018 Journal of Global Antimicrobial Resistance Antimicrobial stewardship Antibiotic resistance Salmonella Meat |
| title | Fluoroquinolone sales in food animals and quinolone resistance in non-typhoidal Salmonella from retail meats: United States, 2009–2018 |
| title_full | Fluoroquinolone sales in food animals and quinolone resistance in non-typhoidal Salmonella from retail meats: United States, 2009–2018 |
| title_fullStr | Fluoroquinolone sales in food animals and quinolone resistance in non-typhoidal Salmonella from retail meats: United States, 2009–2018 |
| title_full_unstemmed | Fluoroquinolone sales in food animals and quinolone resistance in non-typhoidal Salmonella from retail meats: United States, 2009–2018 |
| title_short | Fluoroquinolone sales in food animals and quinolone resistance in non-typhoidal Salmonella from retail meats: United States, 2009–2018 |
| title_sort | fluoroquinolone sales in food animals and quinolone resistance in non typhoidal salmonella from retail meats united states 2009 2018 |
| topic | Antimicrobial stewardship Antibiotic resistance Salmonella Meat |
| url | http://www.sciencedirect.com/science/article/pii/S2213716522000595 |
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