Comparative Analysis of the Kinetic Behavior of Systemic Inflammatory Markers in Patients with Depressed versus Preserved Left Ventricular Function Undergoing Transcatheter Aortic Valve Implantation
Background: Prior studies have proven the safety and efficacy of transcatheter aortic valve implantation (TAVI) in patients with reduced left ventricular (LV) function. This study’s aim was to investigate periprocedural inflammatory responses after TAVI. Methods: Patients with severe symptomatic aor...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-09-01
|
| Series: | Journal of Clinical Medicine |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2077-0383/10/18/4148 |
| _version_ | 1797518726016270336 |
|---|---|
| author | Haitham Abu Khadija Gera Gandelman Omar Ayyad Lion Poles Michael Jonas Offir Paz Sorel Goland Sara Shimoni Valery Meledin Jacob George Alex Blatt |
| author_facet | Haitham Abu Khadija Gera Gandelman Omar Ayyad Lion Poles Michael Jonas Offir Paz Sorel Goland Sara Shimoni Valery Meledin Jacob George Alex Blatt |
| author_sort | Haitham Abu Khadija |
| collection | DOAJ |
| description | Background: Prior studies have proven the safety and efficacy of transcatheter aortic valve implantation (TAVI) in patients with reduced left ventricular (LV) function. This study’s aim was to investigate periprocedural inflammatory responses after TAVI. Methods: Patients with severe symptomatic aortic stenosis and reduced LV function who underwent transfemoral TAVI were enrolled. A paired-matched analysis (1:2 ratio) was performed using patients with preserved LV function. Whole white blood cells (WBC) and subpopulation dynamics as well as the neutrophil to lymphocyte ratio (NLR) were evaluated at different times. Results: A total of 156 patients were enrolled, including 52 patients with LVEF < 40% 35.00 [30.00, 39.25] and 104 with LVEF > 50% 55.00 [53.75, 60.0], <i>p</i> < 0.001. Baseline NLR in the reduced LV function group was significantly higher compared to the preserved LV function group, 2.85 [2.07, 4.78] vs. 3.90 [2.67, 5.26], <i>p</i> < 0.04. After a six-month follow-up, the inflammatory profile was found to be similar in the two groups, NLR 2.94 [2.01, 388] vs. 3.30 [2.06, 5.35], <i>p</i> = 0.288. No significant mortality differences between the two groups were observed in the long-term outcome. Conclusions: TAVI for severe symptomatic aortic stenosis, with reduced LV function, was associated with an improvement in the inflammatory profile that may account for some of the observable benefits of the procedure in this subset of patients. |
| first_indexed | 2024-03-10T07:33:41Z |
| format | Article |
| id | doaj.art-3c9213be7f9e499c93d2c64ecb0d3f52 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T07:33:41Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-3c9213be7f9e499c93d2c64ecb0d3f522023-11-22T13:40:14ZengMDPI AGJournal of Clinical Medicine2077-03832021-09-011018414810.3390/jcm10184148Comparative Analysis of the Kinetic Behavior of Systemic Inflammatory Markers in Patients with Depressed versus Preserved Left Ventricular Function Undergoing Transcatheter Aortic Valve ImplantationHaitham Abu Khadija0Gera Gandelman1Omar Ayyad2Lion Poles3Michael Jonas4Offir Paz5Sorel Goland6Sara Shimoni7Valery Meledin8Jacob George9Alex Blatt10Kaplan Heart Center, Kaplan Medical Center, Rehovot, Affiliated with the Hebrew University, Jerusalem 76610, IsraelKaplan Heart Center, Kaplan Medical Center, Rehovot, Affiliated with the Hebrew University, Jerusalem 76610, IsraelKaplan Heart Center, Kaplan Medical Center, Rehovot, Affiliated with the Hebrew University, Jerusalem 76610, IsraelKaplan Heart Center, Kaplan Medical Center, Rehovot, Affiliated with the Hebrew University, Jerusalem 76610, IsraelKaplan Heart Center, Kaplan Medical Center, Rehovot, Affiliated with the Hebrew University, Jerusalem 76610, IsraelKaplan Heart Center, Kaplan Medical Center, Rehovot, Affiliated with the Hebrew University, Jerusalem 76610, IsraelKaplan Heart Center, Kaplan Medical Center, Rehovot, Affiliated with the Hebrew University, Jerusalem 76610, IsraelKaplan Heart Center, Kaplan Medical Center, Rehovot, Affiliated with the Hebrew University, Jerusalem 76610, IsraelKaplan Heart Center, Kaplan Medical Center, Rehovot, Affiliated with the Hebrew University, Jerusalem 76610, IsraelKaplan Heart Center, Kaplan Medical Center, Rehovot, Affiliated with the Hebrew University, Jerusalem 76610, IsraelKaplan Heart Center, Kaplan Medical Center, Rehovot, Affiliated with the Hebrew University, Jerusalem 76610, IsraelBackground: Prior studies have proven the safety and efficacy of transcatheter aortic valve implantation (TAVI) in patients with reduced left ventricular (LV) function. This study’s aim was to investigate periprocedural inflammatory responses after TAVI. Methods: Patients with severe symptomatic aortic stenosis and reduced LV function who underwent transfemoral TAVI were enrolled. A paired-matched analysis (1:2 ratio) was performed using patients with preserved LV function. Whole white blood cells (WBC) and subpopulation dynamics as well as the neutrophil to lymphocyte ratio (NLR) were evaluated at different times. Results: A total of 156 patients were enrolled, including 52 patients with LVEF < 40% 35.00 [30.00, 39.25] and 104 with LVEF > 50% 55.00 [53.75, 60.0], <i>p</i> < 0.001. Baseline NLR in the reduced LV function group was significantly higher compared to the preserved LV function group, 2.85 [2.07, 4.78] vs. 3.90 [2.67, 5.26], <i>p</i> < 0.04. After a six-month follow-up, the inflammatory profile was found to be similar in the two groups, NLR 2.94 [2.01, 388] vs. 3.30 [2.06, 5.35], <i>p</i> = 0.288. No significant mortality differences between the two groups were observed in the long-term outcome. Conclusions: TAVI for severe symptomatic aortic stenosis, with reduced LV function, was associated with an improvement in the inflammatory profile that may account for some of the observable benefits of the procedure in this subset of patients.https://www.mdpi.com/2077-0383/10/18/4148TAVITAVRinflammationneutrophil–lymphocyte ratioNLRLVEF |
| spellingShingle | Haitham Abu Khadija Gera Gandelman Omar Ayyad Lion Poles Michael Jonas Offir Paz Sorel Goland Sara Shimoni Valery Meledin Jacob George Alex Blatt Comparative Analysis of the Kinetic Behavior of Systemic Inflammatory Markers in Patients with Depressed versus Preserved Left Ventricular Function Undergoing Transcatheter Aortic Valve Implantation Journal of Clinical Medicine TAVI TAVR inflammation neutrophil–lymphocyte ratio NLR LVEF |
| title | Comparative Analysis of the Kinetic Behavior of Systemic Inflammatory Markers in Patients with Depressed versus Preserved Left Ventricular Function Undergoing Transcatheter Aortic Valve Implantation |
| title_full | Comparative Analysis of the Kinetic Behavior of Systemic Inflammatory Markers in Patients with Depressed versus Preserved Left Ventricular Function Undergoing Transcatheter Aortic Valve Implantation |
| title_fullStr | Comparative Analysis of the Kinetic Behavior of Systemic Inflammatory Markers in Patients with Depressed versus Preserved Left Ventricular Function Undergoing Transcatheter Aortic Valve Implantation |
| title_full_unstemmed | Comparative Analysis of the Kinetic Behavior of Systemic Inflammatory Markers in Patients with Depressed versus Preserved Left Ventricular Function Undergoing Transcatheter Aortic Valve Implantation |
| title_short | Comparative Analysis of the Kinetic Behavior of Systemic Inflammatory Markers in Patients with Depressed versus Preserved Left Ventricular Function Undergoing Transcatheter Aortic Valve Implantation |
| title_sort | comparative analysis of the kinetic behavior of systemic inflammatory markers in patients with depressed versus preserved left ventricular function undergoing transcatheter aortic valve implantation |
| topic | TAVI TAVR inflammation neutrophil–lymphocyte ratio NLR LVEF |
| url | https://www.mdpi.com/2077-0383/10/18/4148 |
| work_keys_str_mv | AT haithamabukhadija comparativeanalysisofthekineticbehaviorofsystemicinflammatorymarkersinpatientswithdepressedversuspreservedleftventricularfunctionundergoingtranscatheteraorticvalveimplantation AT geragandelman comparativeanalysisofthekineticbehaviorofsystemicinflammatorymarkersinpatientswithdepressedversuspreservedleftventricularfunctionundergoingtranscatheteraorticvalveimplantation AT omarayyad comparativeanalysisofthekineticbehaviorofsystemicinflammatorymarkersinpatientswithdepressedversuspreservedleftventricularfunctionundergoingtranscatheteraorticvalveimplantation AT lionpoles comparativeanalysisofthekineticbehaviorofsystemicinflammatorymarkersinpatientswithdepressedversuspreservedleftventricularfunctionundergoingtranscatheteraorticvalveimplantation AT michaeljonas comparativeanalysisofthekineticbehaviorofsystemicinflammatorymarkersinpatientswithdepressedversuspreservedleftventricularfunctionundergoingtranscatheteraorticvalveimplantation AT offirpaz comparativeanalysisofthekineticbehaviorofsystemicinflammatorymarkersinpatientswithdepressedversuspreservedleftventricularfunctionundergoingtranscatheteraorticvalveimplantation AT sorelgoland comparativeanalysisofthekineticbehaviorofsystemicinflammatorymarkersinpatientswithdepressedversuspreservedleftventricularfunctionundergoingtranscatheteraorticvalveimplantation AT sarashimoni comparativeanalysisofthekineticbehaviorofsystemicinflammatorymarkersinpatientswithdepressedversuspreservedleftventricularfunctionundergoingtranscatheteraorticvalveimplantation AT valerymeledin comparativeanalysisofthekineticbehaviorofsystemicinflammatorymarkersinpatientswithdepressedversuspreservedleftventricularfunctionundergoingtranscatheteraorticvalveimplantation AT jacobgeorge comparativeanalysisofthekineticbehaviorofsystemicinflammatorymarkersinpatientswithdepressedversuspreservedleftventricularfunctionundergoingtranscatheteraorticvalveimplantation AT alexblatt comparativeanalysisofthekineticbehaviorofsystemicinflammatorymarkersinpatientswithdepressedversuspreservedleftventricularfunctionundergoingtranscatheteraorticvalveimplantation |