A Case Series of Rifabutin Use in Staphylococcal Prosthetic Infections
ABSTRACT This case series describes seven patients who received rifabutin in place of rifampin combined with conventional antimicrobial therapy for treatment of hardware-associated staphylococcal infections. Infection recurrence, defined as need for unplanned surgical intervention within the evaluab...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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American Society for Microbiology
2022-06-01
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| Series: | Microbiology Spectrum |
| Subjects: | |
| Online Access: | https://journals.asm.org/doi/10.1128/spectrum.00384-22 |
| _version_ | 1818546821716246528 |
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| author | Miranda Monk Ramy Elshaboury Alexander Tatara Sandra Nelson Monique R. Bidell |
| author_facet | Miranda Monk Ramy Elshaboury Alexander Tatara Sandra Nelson Monique R. Bidell |
| author_sort | Miranda Monk |
| collection | DOAJ |
| description | ABSTRACT This case series describes seven patients who received rifabutin in place of rifampin combined with conventional antimicrobial therapy for treatment of hardware-associated staphylococcal infections. Infection recurrence, defined as need for unplanned surgical intervention within the evaluable follow up period after starting rifabutin, occurred in two patients. Two patients experienced possible treatment-associated adverse effects. Findings support future work to examine rifabutin use, when rifampin is not suitable, for adjunctive treatment of staphylococcal hardware infections. IMPORTANCE This work evaluates real-world data and clinical outcomes when rifabutin is used in place of rifampin for adjunctive management of staphylococcal hardware-associated infections. This is the second case study looking at this specific use of rifabutin, signifying the current lack of clinical data in this area. Assessing use of rifabutin in this capacity is clinically important given its lower propensity for drug interactions compared to rifampin. |
| first_indexed | 2024-12-12T07:58:21Z |
| format | Article |
| id | doaj.art-3c926f0faae145aea46600019638e435 |
| institution | Directory Open Access Journal |
| issn | 2165-0497 |
| language | English |
| last_indexed | 2024-12-12T07:58:21Z |
| publishDate | 2022-06-01 |
| publisher | American Society for Microbiology |
| record_format | Article |
| series | Microbiology Spectrum |
| spelling | doaj.art-3c926f0faae145aea46600019638e4352022-12-22T00:32:13ZengAmerican Society for MicrobiologyMicrobiology Spectrum2165-04972022-06-0110310.1128/spectrum.00384-22A Case Series of Rifabutin Use in Staphylococcal Prosthetic InfectionsMiranda Monk0Ramy Elshaboury1Alexander Tatara2Sandra Nelson3Monique R. Bidell4Department of Pharmacy, Massachusetts General Hospital, Boston, Massachusetts, USADepartment of Pharmacy, Massachusetts General Hospital, Boston, Massachusetts, USADepartment of Medicine, Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, USADepartment of Medicine, Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, USADepartment of Pharmacy, Massachusetts General Hospital, Boston, Massachusetts, USAABSTRACT This case series describes seven patients who received rifabutin in place of rifampin combined with conventional antimicrobial therapy for treatment of hardware-associated staphylococcal infections. Infection recurrence, defined as need for unplanned surgical intervention within the evaluable follow up period after starting rifabutin, occurred in two patients. Two patients experienced possible treatment-associated adverse effects. Findings support future work to examine rifabutin use, when rifampin is not suitable, for adjunctive treatment of staphylococcal hardware infections. IMPORTANCE This work evaluates real-world data and clinical outcomes when rifabutin is used in place of rifampin for adjunctive management of staphylococcal hardware-associated infections. This is the second case study looking at this specific use of rifabutin, signifying the current lack of clinical data in this area. Assessing use of rifabutin in this capacity is clinically important given its lower propensity for drug interactions compared to rifampin.https://journals.asm.org/doi/10.1128/spectrum.00384-22Staphylococcusbiofilmsdrug interactionsprosthesis infectionsrifabutinrifampin |
| spellingShingle | Miranda Monk Ramy Elshaboury Alexander Tatara Sandra Nelson Monique R. Bidell A Case Series of Rifabutin Use in Staphylococcal Prosthetic Infections Microbiology Spectrum Staphylococcus biofilms drug interactions prosthesis infections rifabutin rifampin |
| title | A Case Series of Rifabutin Use in Staphylococcal Prosthetic Infections |
| title_full | A Case Series of Rifabutin Use in Staphylococcal Prosthetic Infections |
| title_fullStr | A Case Series of Rifabutin Use in Staphylococcal Prosthetic Infections |
| title_full_unstemmed | A Case Series of Rifabutin Use in Staphylococcal Prosthetic Infections |
| title_short | A Case Series of Rifabutin Use in Staphylococcal Prosthetic Infections |
| title_sort | case series of rifabutin use in staphylococcal prosthetic infections |
| topic | Staphylococcus biofilms drug interactions prosthesis infections rifabutin rifampin |
| url | https://journals.asm.org/doi/10.1128/spectrum.00384-22 |
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