Cytokine Storm: The Primary Determinant for the Pathophysiological Evolution of COVID-19 Deterioration
The coronavirus disease 2019 (COVID-19) pandemic caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an ongoing major threat to global health and has posed significant challenges for the treatment of severely ill COVID-19 patients. Several studies have reported that c...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-04-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2021.589095/full |
| _version_ | 1818726431070355456 |
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| author | Ruirong Chen Zhien Lan Jujian Ye Limin Pang Yi Liu Wei Wu Xiaohuan Qin Yang Guo Peidong Zhang |
| author_facet | Ruirong Chen Zhien Lan Jujian Ye Limin Pang Yi Liu Wei Wu Xiaohuan Qin Yang Guo Peidong Zhang |
| author_sort | Ruirong Chen |
| collection | DOAJ |
| description | The coronavirus disease 2019 (COVID-19) pandemic caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an ongoing major threat to global health and has posed significant challenges for the treatment of severely ill COVID-19 patients. Several studies have reported that cytokine storms are an important cause of disease deterioration and death in COVID-19 patients. Consequently, it is important to understand the specific pathophysiological processes underlying how cytokine storms promote the deterioration of COVID-19. Here, we outline the pathophysiological processes through which cytokine storms contribute to the deterioration of SARS-CoV-2 infection and describe the interaction between SARS-CoV-2 and the immune system, as well as the pathophysiology of immune response dysfunction that leads to acute respiratory distress syndrome (ARDS), multi-organ dysfunction syndrome (MODS), and coagulation impairment. Treatments based on inhibiting cytokine storm-induced deterioration and occurrence are also described. |
| first_indexed | 2024-12-17T21:58:05Z |
| format | Article |
| id | doaj.art-3c92770b59ff4d16a03da2b8c628da7c |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-17T21:58:05Z |
| publishDate | 2021-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-3c92770b59ff4d16a03da2b8c628da7c2022-12-21T21:31:04ZengFrontiers Media S.A.Frontiers in Immunology1664-32242021-04-011210.3389/fimmu.2021.589095589095Cytokine Storm: The Primary Determinant for the Pathophysiological Evolution of COVID-19 DeteriorationRuirong Chen0Zhien Lan1Jujian Ye2Limin Pang3Yi Liu4Wei Wu5Xiaohuan Qin6Yang Guo7Peidong Zhang8Department of Cardiology, Heart Center, Zhujiang Hospital, Southern Medical University/The Second School of Clinical Medicine, Southern Medical University, Guangzhou, ChinaDepartment of Cardiology, Heart Center, Zhujiang Hospital, Southern Medical University/The Second School of Clinical Medicine, Southern Medical University, Guangzhou, ChinaDepartment of Cardiology, Heart Center, Zhujiang Hospital, Southern Medical University/The Second School of Clinical Medicine, Southern Medical University, Guangzhou, ChinaDepartment of Cardiology, Heart Center, Zhujiang Hospital, Southern Medical University/The Second School of Clinical Medicine, Southern Medical University, Guangzhou, ChinaDepartment of Cardiology, Heart Center, Zhujiang Hospital, Southern Medical University/The Second School of Clinical Medicine, Southern Medical University, Guangzhou, ChinaDepartment of Cardiology, Heart Center, Zhujiang Hospital, Southern Medical University/The Second School of Clinical Medicine, Southern Medical University, Guangzhou, ChinaDepartment of Cardiology, Heart Center, Zhujiang Hospital, Southern Medical University/The Second School of Clinical Medicine, Southern Medical University, Guangzhou, ChinaDepartment of Neurology, Zhujiang Hospital, Southern Medical University, Guangzhou, ChinaDepartment of Cardiology, Heart Center, Zhujiang Hospital, Southern Medical University/The Second School of Clinical Medicine, Southern Medical University, Guangzhou, ChinaThe coronavirus disease 2019 (COVID-19) pandemic caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an ongoing major threat to global health and has posed significant challenges for the treatment of severely ill COVID-19 patients. Several studies have reported that cytokine storms are an important cause of disease deterioration and death in COVID-19 patients. Consequently, it is important to understand the specific pathophysiological processes underlying how cytokine storms promote the deterioration of COVID-19. Here, we outline the pathophysiological processes through which cytokine storms contribute to the deterioration of SARS-CoV-2 infection and describe the interaction between SARS-CoV-2 and the immune system, as well as the pathophysiology of immune response dysfunction that leads to acute respiratory distress syndrome (ARDS), multi-organ dysfunction syndrome (MODS), and coagulation impairment. Treatments based on inhibiting cytokine storm-induced deterioration and occurrence are also described.https://www.frontiersin.org/articles/10.3389/fimmu.2021.589095/fullcytokine stormssevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)acute respiratory distress syndrome (ARDS)multi-organ dysfunction syndrome (MODS)coronavirus disease 2019 (COVID-19) |
| spellingShingle | Ruirong Chen Zhien Lan Jujian Ye Limin Pang Yi Liu Wei Wu Xiaohuan Qin Yang Guo Peidong Zhang Cytokine Storm: The Primary Determinant for the Pathophysiological Evolution of COVID-19 Deterioration Frontiers in Immunology cytokine storms severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) acute respiratory distress syndrome (ARDS) multi-organ dysfunction syndrome (MODS) coronavirus disease 2019 (COVID-19) |
| title | Cytokine Storm: The Primary Determinant for the Pathophysiological Evolution of COVID-19 Deterioration |
| title_full | Cytokine Storm: The Primary Determinant for the Pathophysiological Evolution of COVID-19 Deterioration |
| title_fullStr | Cytokine Storm: The Primary Determinant for the Pathophysiological Evolution of COVID-19 Deterioration |
| title_full_unstemmed | Cytokine Storm: The Primary Determinant for the Pathophysiological Evolution of COVID-19 Deterioration |
| title_short | Cytokine Storm: The Primary Determinant for the Pathophysiological Evolution of COVID-19 Deterioration |
| title_sort | cytokine storm the primary determinant for the pathophysiological evolution of covid 19 deterioration |
| topic | cytokine storms severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) acute respiratory distress syndrome (ARDS) multi-organ dysfunction syndrome (MODS) coronavirus disease 2019 (COVID-19) |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2021.589095/full |
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